CLINICAL TRIAL

Magventure MagProx100 with MagOption for Chronic Pain

Recruiting · 18+ · All Sexes · Hines, IL

This study is evaluating whether a combination of neuromodulation and yoga may help improve quality of life and pain for veterans with mild traumatic brain injury.

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About the trial for Chronic Pain

Eligible Conditions
Chronic Pain · Brain Injuries, Traumatic · Mild Traumatic Brain Injury (MTBI) · Brain Injuries · Brain Concussion

Treatment Groups

This trial involves 2 different treatments. Magventure MagProx100 With MagOption is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Main TreatmentA portion of participants receive this new treatment to see if it outperforms the control.
Magventure MagProx100 with MagOption
DEVICE
Control TreatmentAnother portion of participants receive the standard treatment to act as a baseline.

Eligibility

This trial is for patients born any sex aged 18 and older. There are 5 eligibility criteria to participate in this trial as listed below.

Inclusion & Exclusion Checklist
Mark “yes” if the following statements are true for you:
The Symptom Attribution and Classification (SACA) criteria for mTBI can be used to diagnose mTBI in individuals without clinical neuropsychological impairment show original
Chronic pain refers to pain that persists for more than six months and is of moderate to severe intensity, as measured by the Brief Pain Inventory (BPI) questionnaire. show original
22+ years of age
I can read and speak English. show original
They feel they are able to take part in gentle physical activities and have been cleared by a doctor to do so. show original
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Odds of Eligibility
Unknown<50%
Be sure to apply to 2-3 other trials, as you have a low likelihood of qualifying for this one.Apply To This Trial
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Approximate Timelines

Please note that timelines for treatment and screening will vary by patient
Screening: ~3 weeks
Treatment: varies
Reporting: Endpoint - after last iTBS+yoga session, approximately 6 weeks
Screening: ~3 weeks
Treatment: Varies
Reporting: Endpoint - after last iTBS+yoga session, approximately 6 weeks
This trial has approximate timelines as follows: 3 weeks for initial screening, variable treatment timelines, and reporting: Endpoint - after last iTBS+yoga session, approximately 6 weeks.
View detailed reporting requirements
Trial Expert
Connect with the researchersHop on a 15 minute call & ask questions about:
- What options you have available- The pros & cons of this trial
- Whether you're likely to qualify- What the enrollment process looks like

Measurement Requirements

This trial is evaluating whether Magventure MagProx100 with MagOption will improve 2 primary outcomes and 2 secondary outcomes in patients with Chronic Pain. Measurement will happen over the course of Baseline (Pre-iTBS+yoga treatment) and Endpoint (after last iTBS+yoga treatment, approximately 6 weeks).

Brief Pain Inventory
BASELINE (PRE-ITBS+YOGA TREATMENT) AND ENDPOINT (AFTER LAST ITBS+YOGA TREATMENT, APPROXIMATELY 6 WEEKS)
The Brief Pain Inventory is a self-report measure of pain symptoms throughout the body. It has 6 main items and each item is scored on a scale of 0 to 10 with 0 meaning no pain (better), and 10 meaning pain as bad as you can imagine (worse). Minimum (best) score would be 0 and maximum (worst) score would be 50.
BASELINE (PRE-ITBS+YOGA TREATMENT) AND ENDPOINT (AFTER LAST ITBS+YOGA TREATMENT, APPROXIMATELY 6 WEEKS)
Mayo-Portland Adaptability Index
BASELINE (PRE-ITBS+YOGA TREATMENT) AND ENDPOINT (AFTER LAST ITBS+YOGA TREATMENT, APPROXIMATELY 6 WEEKS)
The Mayo-Portland Adaptability Index is a TBI Common Data Element assessment of function and participation. It includes 35 items each scored on a scale of 0 to 4, with 0 meaning no problems (better), and 4 meaning severe problems (worse). Minimum (best) score would be 0 and maximum (worst) score would be 140.
BASELINE (PRE-ITBS+YOGA TREATMENT) AND ENDPOINT (AFTER LAST ITBS+YOGA TREATMENT, APPROXIMATELY 6 WEEKS)
Semi-structured qualitative interviews of acceptability
ENDPOINT - AFTER LAST ITBS+YOGA SESSION, APPROXIMATELY 6 WEEKS
Regarding acceptability, the semi-structured interviews will be audio-recorded, transcribed verbatim and analyzed by 2 qualitative experts using thematic coding and constant comparison techniques. Qualitative analysis software will be used to support analyses.
ENDPOINT - AFTER LAST ITBS+YOGA SESSION, APPROXIMATELY 6 WEEKS
Session Completion Rate
ENDPOINT - AFTER LAST ITBS+YOGA SESSION, APPROXIMATELY 6 WEEKS
For feasibility, we will track the number of iTBS+yoga sessions completed and compute completion percentage rates for each participant as a metric of feasibility.
ENDPOINT - AFTER LAST ITBS+YOGA SESSION, APPROXIMATELY 6 WEEKS

Patient Q & A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Can chronic pain be cured?

Chronic pain has a profound impact on both the patient and the family. Although the term 'cure' may seem to suggest that chronic pain has been 'eliminated', no such cure exists. Pain management, coupled with exercise, education, diet and supportive psychotherapy should be considered in a multidisciplinary team setting.

Anonymous Patient Answer

What are common treatments for chronic pain?

The treatments most often used are medications (drugs, supplements, and therapies), behavioral therapies (exercise, relaxation techniques, coping strategies), and technology (rehabilitation, surgical procedures, and self-management techniques). Medications and behavioral interventions are typically used first, then surgery or therapy in order to manage the pain. There is limited evidence that alternative medicine has positive effects on patient experiences of chronic pain.

Anonymous Patient Answer

How many people get chronic pain a year in the United States?

Chronic pain is common in the U. S., and chronic pain is now a more frequent outcome than a diagnosis of any other medical condition, including heart attack, stroke, or hip fracture. Therefore, there may be a need to develop better therapies for chronic pain.

Anonymous Patient Answer

What is chronic pain?

In the United States chronic pain is more common than any other chronic condition. It is estimated that 10%-20% of chronic pain patients are under diagnosed and undertreated. The diagnosis of chronic pain is often overlooked and undertreated in primary care offices due to the complexity of chronic pain pathology.

Anonymous Patient Answer

Does chronic pain run in families?

Although the results of this study do not prove the existence of a familial or genetic component in chronic pain, the findings are consistent with genetic contribution to chronic pain and are consistent with the existing literature. In addition, our findings also indicate that further investigations into specific genetic factors, and underlying biological mechanisms, that may underlie the chronic pain phenotype may be warranted.

Anonymous Patient Answer

Is magventure magprox100 with magoption typically used in combination with any other treatments?

The combination of the two treatments could be an interesting combination. Magoption is not effective in managing CP/RSD alone, and the results suggest that combined use with other treatment methods may have a higher efficacy than those in single-treatment models.

Anonymous Patient Answer

What is the average age someone gets chronic pain?

On average it's a little under 52 years old in North America, according to the 2010 US Census. Women seem to get it a little bit younger than men. That said, that difference diminishes slowly, or steadily, over a lifetime, and most older people get the condition. But if your time of relevance to your [chronic pain](https://www.withpower.com/clinical-trials/chronic-pain) is in the future, you may end up older, because younger people live longer and their pain is generally debilitating, and less likely to be addressed surgically, or surgically and medically, at all.\n\nKaren J.

Anonymous Patient Answer

What are the signs of chronic pain?

Pain is a subjective experience that affects thinking and behavior. To understand this phenomenon, a complex interplay needs to be explored between neurological systems, psychological processes, and pain perception. Clinicians must recognize when the pain signals in a patient are a symptom of disease or a normal physiological response to need. If a patient has pain that does not improve with normal treatments, this could mean a chronic pain disorder is an initial diagnosis. If we become aware of the potential of chronic pain, we should work to determine and appropriately treat the underlying cause as early as possible. The signs of chronic pain, as stated in these questions, should alert us to the possibility of a chronic pain problem.

Anonymous Patient Answer

What causes chronic pain?

Chronic pain is probably caused by a complex interaction between genetic predisposition, brain circuitry, neuroendocrine, neural, and immune pathways, and functional and structural tissue changes. Chronic pain syndromes can be difficult to treat and disrupt an individual's daily life. It is crucial for health professionals to understand the complexity of the problem and to have a deep suspicion of the possibility of missed opportunities in the management of chronic pain and the need to consider other possibilities.

Anonymous Patient Answer

What is magventure magprox100 with magoption?

Recent findings suggests that a potential therapeutic target for reducing muscle wasting in chronic inflammatory musculoskeletal conditions is the expression of proinflammatory cytokines. Magprox100 decreases muscle wasting by suppressing mRNA levels of cytokines and collagen synthase II.

Anonymous Patient Answer

Have there been any new discoveries for treating chronic pain?

Recent findings confirmed that the use of multimodal therapies appeared to be effective for patients with chronic pain, which was seen as a significant achievement. Further studies will need to be undertaken to confirm these findings. Clinical research.

Anonymous Patient Answer

What are the common side effects of magventure magprox100 with magoption?

There is little evidence for serious adverse effects. No specific reaction is mentioned in the manufacturer's prescribing information. Magoption does not cause sedation or respiratory depression. These conclusions are similar to those of previous studies with sub-trend efficacy. However, the clinical significance of these results has not been fully evaluated in more recent studies. Although magprox 100, with or without other anti-pain medication may provide some improvement to some people for pain, these data only provide indications of effectiveness in a limited group of people. Further studies are needed to assess the significance of the present observations, since magprox 100 may be a valid alternative for people at risk for developing addiction and/or a cause of an addiction.

Anonymous Patient Answer
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