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Procedure

Atrial Fibrillation (AF) Catheter Ablation for Obesity (BAROS Trial)

N/A
Waitlist Available
Led By Paul J Wang, MD
Research Sponsored by Stanford University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Symptomatic persistent or paroxysmal AF refractory to at least one antiarrhythmic agent
EF > 40%
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline (initial), 12 months
Awards & highlights

BAROS Trial Summary

This trial will compare two procedures for treating atrial fibrillation in obese patients.

Eligible Conditions
  • Obesity
  • Atrial Fibrillation

BAROS Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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You have hyperlipidemia and your cholesterol is not controlled with diet and medication.
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You have documented pseudotumor cerebri.
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You have severe arthropathy of spine and/or weight-bearing joints.

BAROS Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline (initial), 12 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline (initial), 12 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Time to first recurrence of AF following a 3-month blanking period after the ablation.
Secondary outcome measures
Change from Baseline in AF Quality of Life Score
Change from Baseline in AF symptom severity
Change in AF Burden off anti-arrhythmic agents monitor

BAROS Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Bariatric surgery prior to AF Catheter Ablation-Group BExperimental Treatment2 Interventions
Participants will undergo either a Roux-en-Y gastric bypass or a laparoscopic sleeve gastrectomy. The choice of the procedure will be based on numerous factors including current practice, the surgeon's and participant's choice, BMI, and the presence of certain comorbidities and their severity such as GERD, kidney stones, and past surgical history. Participants will undergo standard preoperative evaluation including dietary consultation and psychological evaluation during the eligibility process. After bariatric surgery, in addition to routine post-surgical management, patients will follow up with cardiologist prior to AF catheter ablation.
Group II: Atrial Fibrillation (AF) Catheter Ablation-Group AActive Control1 Intervention
Participants will undergo catheter ablation using either radiofrequency or cryo-ablation of pulmonary veins. Participants with persistent AF may also undergo roof and/or floor linear ablation with or without ablation of extra-pulmonary sites at the physician's discretion.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Bariatric surgery
2013
Completed Phase 4
~15460

Find a Location

Who is running the clinical trial?

Stanford UniversityLead Sponsor
2,374 Previous Clinical Trials
17,332,926 Total Patients Enrolled
70 Trials studying Obesity
270,236 Patients Enrolled for Obesity
Paul J Wang, MDPrincipal InvestigatorDirector Stanford Electrophysiology and Arrhythmia Service, Stanford University
2 Previous Clinical Trials
1,201 Total Patients Enrolled
Dan E Azagury, MDPrincipal InvestigatorAssistant Professor of Surgery, Bariatric & Minimally Invasive Surgery
2 Previous Clinical Trials
243 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Who else is applying?

What state do they live in?
California
How old are they?
18 - 65
What portion of applicants met pre-screening criteria?
Did not meet criteria
Recent research and studies
~0 spots leftby Mar 2025