Breathing exercise for Atrial Fibrillation

Phase-Based Estimates
1
Effectiveness
1
Safety
Laureate Institute for Brain Research, Tulsa, OK
Atrial Fibrillation+1 More
Breathing exercise - Behavioral
Eligibility
18+
All Sexes
Eligible conditions
Atrial Fibrillation

Study Summary

This study is evaluating whether a breathing training intervention may help reduce anxiety in adults with cardiac arrhythmias.

See full description

Eligible Conditions

  • Atrial Fibrillation
  • Implantable Cardioverter-defibrillators (ICDs)

Treatment Effectiveness

Effectiveness Estimate

1 of 3

Study Objectives

This trial is evaluating whether Breathing exercise will improve 1 primary outcome and 4 secondary outcomes in patients with Atrial Fibrillation. Measurement will happen over the course of 1 month.

1 month
Arrhythmia burden
Cardiac anxiety
Disability
ICD anxiety
Wellbeing

Trial Safety

Safety Estimate

1 of 3

Trial Design

2 Treatment Groups

Control
Breathing exercise

This trial requires 12 total participants across 2 different treatment groups

This trial involves 2 different treatments. Breathing Exercise is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Breathing exercise
Behavioral
Participants will perform a paced breathing intervention (slow breathing) prompted by pseudorandomized remote reminders (scheduled reminders plus non scheduled reminders), through cellular phone application.
ControlNo treatment in the control group
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Breathing exercise
2013
N/A
~130

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 1 month
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly 1 month for reporting.

Closest Location

Laureate Institute for Brain Research - Tulsa, OK

Eligibility Criteria

This trial is for patients born any sex aged 18 and older. There are 4 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
Age 18 to 80
BMI 17 to 35
Proficient in English language
Paroxysmal atrial fibrillation or ventricular fibrillation or frequent premature atrial/ventricular contractions

Patient Q&A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Can atrial fibrillation be cured?

Add answer

Contrary to popular misconception there is no evidence to suggest that atrial fibrillation is cureable. The most common symptom reported by most patients with atrial fibrillation is symptom fluctuation. The best treatment is therefore symptom control as in any other condition where symptoms are variable in nature.

Unverified Answer

What are the signs of atrial fibrillation?

Add answer

Atrial fibrillation can present with a wide range of symptoms including a range of abnormal heart rates such as tachycardia, bradycardia, atrial rate and no rhythm. These symptoms are typically found at rest, in the morning or late evenings.

Unverified Answer

What is atrial fibrillation?

Add answer

Atrial fibrillation is an abnormal heart rhythm that can occur in people of any age. It arises mostly in the brain and spreads to the rest of the heart via the atrioventricular (AV) node. Atrial fibrillation is common in hospital inpatients but is usually asymptomatic and rarely requires treatment.

Unverified Answer

What causes atrial fibrillation?

Add answer

Atherosclerosis, especially with plaques as a complication of carotid atherosclerosis, may be the cause of AF. The "clot in the atrium" is likely a result of atrial and left atrial thrombosis from atrial blood-thrombus formation.

Unverified Answer

How many people get atrial fibrillation a year in the United States?

Add answer

The incidence of AF in adults ≥30 years is estimated to be 2.2, i.e., nearly 1 out of every 100 adults in the US had AF.

Unverified Answer

What are common treatments for atrial fibrillation?

Add answer

Various antiarrhythmic medications are used including antiarrhythmic steroids, beta-blocking agents, cardioversion, catheter ablation, and anticoagulation. A multitude of drugs are used in management of AF and it is difficult to recommend a particular therapy in this area.

Unverified Answer

What are the latest developments in breathing exercise for therapeutic use?

Add answer

The studies cited support that breathing exercises are effective in increasing arterial blood pressure and heart rate, improving breathing habits, and decreasing body weight, and therefore, these exercises can be recommended for use in patients who are unable to exercise adequately to strengthen their hearts and counteract the effects of atrial fibrillation.

Unverified Answer

How does breathing exercise work?

Add answer

By combining the two respiratory exercises we observed short- and long-term clinical improvement with exercise training. Results from a recent paper demonstrate that a short period of aerobic training, with a gradual increase of workload, can achieve significant improvements in the health status of patients affected by chronic heart failure.

Unverified Answer

How serious can atrial fibrillation be?

Add answer

The risk of stroke is markedly increased by atrial fibrillation in comparison with the general population and is greatest in women of advancing age. In the population studied it is not uncommon to encounter asymptomatic AF. Although the long term risk of stroke is considerable, a number of randomized studies show that anti-fibrillatory drugs are effective in improving long-term survival, that is to say the time before the patient dies to the time of death from either old age or a sudden or heart attack. In spite of this improvement in survival, mortality following atrial fibrillation is still high. This is a reminder that the treatment of atrial fibrillation must be carefully targeted to reduce the risk of stroke.

Unverified Answer

What is breathing exercise?

Add answer

This is the first study to the effect of breathing exercise in AF patients and the first demonstration of the existence of a physiologic effect on ventricular tachyarrhythmias. Recent findings suggest that breathing exercises may be able to reduce the ventricular tachyarrhythmias and may be helpful in reducing ventricular-universelty. The positive effect on ventricular arrhythmias may be explained by their effect on peripheral vasoconstriction via an acetylcholine-dependent mechanism. Further studies with more homogeneous groups are necessary and can help to further evaluate what breathing exercises may be able to bring as a new treatment strategy for AF patients.

Unverified Answer

Who should consider clinical trials for atrial fibrillation?

Add answer

A large percentage of patients with AF are overlooked in clinical trials. Clinical trials may omit significant patient groups. In future, the incorporation of patients' expectations would improve the identification of patients in AF candidates of clinical trials.

Unverified Answer

Is breathing exercise typically used in combination with any other treatments?

Add answer

Regular breathing exercise is not used as an additional therapy to the standard treatment for symptomatic AF. Recent findings indicate that there are few patients who would be interested in regular breathing exercise as an additional treatment.

Unverified Answer
See if you qualify for this trial
Get access to this novel treatment for Atrial Fibrillation by sharing your contact details with the study coordinator.