Guided Metoprolol Management for Atrial Fibrillation

Phase-Based Progress Estimates
Vanderbilt University Medical Center, Nashville, TNAtrial FibrillationGuided Metoprolol Management - Other
All Sexes
What conditions do you have?

Study Summary

This trial is investigating whether personalized recommendations for the drug metoprolol, based on a patient's genetic makeup, will be more effective in reducing postoperative atrial fibrillation than the standard dosing recommendations.

Eligible Conditions
  • Post-operative Atrial Fibrillation

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

1 Primary · 8 Secondary · Reporting Duration: From end of surgery to hospital discharge; usually 3-4 days

Day 4
Cost of interventions to control or treat post-operative atrial fibrillation
Incidence of adverse drug events
Proportion of clinical decision support tool recommendations that were acknowledged and accepted by provider
Proportion of clinical decision support tool recommendations that were acknowledged but ignored by the provider.
Reasons for non-adherence to recommendations
Day 4
Length of hospital stay
Overall cost of treatment
Day 4
Incidence of post-operative atrial fibrillation
Rate of genome tailored prescription changes

Trial Safety

Safety Progress

1 of 3

Trial Design

1 Treatment Group

Pharmacogenetic-guided metoprolol management
1 of 1

Experimental Treatment

107 Total Participants · 1 Treatment Group

Primary Treatment: Guided Metoprolol Management · No Placebo Group · N/A

Pharmacogenetic-guided metoprolol management
Experimental Group · 1 Intervention: Guided Metoprolol Management · Intervention Types: Other

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: from end of surgery to hospital discharge; usually 3-4 days

Who is running the clinical trial?

Vanderbilt University Medical CenterLead Sponsor
783 Previous Clinical Trials
599,206 Total Patients Enrolled
Miklos Kertai, MD. PhDPrincipal Investigator - Vanderbilt University Medical Center
Vanderbilt University Hospital

Eligibility Criteria

Age 18+ · All Participants · 2 Total Inclusion Criteria

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Frequently Asked Questions

Is enrollment available for this clinical trial?

"Affirmative. According to the information on, recruitment is currently underway for this medical trial which was first posted on March 5th 2021 and recently modified on March 10th 2022. The study needs 400 participants from one site in order to reach completion." - Anonymous Online Contributor

Unverified Answer

What is the estimated size of participation in this medical experiment?

"Yes, the information confirms that this clinical trial is still in search of volunteers. First posted on March 5th 2021 and most recently updated on March 10th 2022, 400 individuals are needed to participate at a single location." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.