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Guided Metoprolol Management for Atrial Fibrillation (PREEMPTIVE Trial)

N/A
Waitlist Available
Led By Miklos Kertai, MD. PhD
Research Sponsored by Vanderbilt University Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Age greater than or equal to 18 years
Scheduled for surgical procedure (coronary artery bypass graft and/or valve repair/replacement) at Vanderbilt University Medical Center
Timeline
Screening 3 weeks
Treatment Varies
Follow Up from end of surgery to hospital discharge; usually 3-4 days
Awards & highlights

PREEMPTIVE Trial Summary

This trial is investigating whether personalized recommendations for the drug metoprolol, based on a patient's genetic makeup, will be more effective in reducing postoperative atrial fibrillation than the standard dosing recommendations.

Eligible Conditions
  • Post-operative Atrial Fibrillation

PREEMPTIVE Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

PREEMPTIVE Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~from end of surgery to hospital discharge; usually 3-4 days
This trial's timeline: 3 weeks for screening, Varies for treatment, and from end of surgery to hospital discharge; usually 3-4 days for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Incidence of post-operative atrial fibrillation
Secondary outcome measures
Cost of interventions to control or treat post-operative atrial fibrillation
Incidence of adverse drug events
Length of hospital stay
+5 more

Side effects data

From 2012 Phase 3 trial • 10251 Patients • NCT00000620
1%
Congestive heart failure
100%
80%
60%
40%
20%
0%
Study treatment Arm
Glycemia Trial: Intensive Control
Glycemia Trial: Standard Control

PREEMPTIVE Trial Design

1Treatment groups
Experimental Treatment
Group I: Pharmacogenetic-guided metoprolol managementExperimental Treatment1 Intervention

Find a Location

Who is running the clinical trial?

Vanderbilt University Medical CenterLead Sponsor
850 Previous Clinical Trials
669,020 Total Patients Enrolled
10 Trials studying Atrial Fibrillation
5,095 Patients Enrolled for Atrial Fibrillation
Miklos Kertai, MD. PhDPrincipal Investigator - Vanderbilt University Medical Center
Vanderbilt University Hospital

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is enrollment available for this clinical trial?

"Affirmative. According to the information on clinicaltrials.gov, recruitment is currently underway for this medical trial which was first posted on March 5th 2021 and recently modified on March 10th 2022. The study needs 400 participants from one site in order to reach completion."

Answered by AI

What is the estimated size of participation in this medical experiment?

"Yes, the information confirms that this clinical trial is still in search of volunteers. First posted on March 5th 2021 and most recently updated on March 10th 2022, 400 individuals are needed to participate at a single location."

Answered by AI
~27 spots leftby Mar 2025