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Procedure
FIRM Ablation for Atrial Fibrillation (SUBSTRATE Trial)
N/A
Waitlist Available
Research Sponsored by University of California, San Diego
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
male or female >21 years
reported incidence of at least two documented episodes of symptomatic paroxysmal atrial fibrillation (AF) during the three months preceding trial entry (at least 1 episode documented by 12-lead ECG or ECG rhythm strip)
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 2 years
Awards & highlights
SUBSTRATE Trial Summary
This trial is testing a new way to ablate atrial fibrillation by targeting specific rotors and focal sources. The hypothesis is that this will be more effective than conventional ablation alone.
SUBSTRATE Trial Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSUBSTRATE Trial Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 2 years
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~2 years
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Long term success
Secondary outcome measures
Adverse events
Consistency of Sources At Repeat Ablation
Long-term freedom from AF/AT
+2 moreSUBSTRATE Trial Design
2Treatment groups
Experimental Treatment
Active Control
Group I: FIRM ablationExperimental Treatment1 Intervention
These patients will be treated by ablation of patient-specific rotors and focal sources (FIRM) alone.
Group II: Conventional AF ablation with PVIActive Control1 Intervention
These patients will treated by conventional AF ablation by pulmonary vein isolation (PVI) alone.
Find a Location
Who is running the clinical trial?
University of California, San DiegoLead Sponsor
1,114 Previous Clinical Trials
1,519,760 Total Patients Enrolled
7 Trials studying Atrial Fibrillation
365 Patients Enrolled for Atrial Fibrillation
National Institutes of Health (NIH)NIH
2,679 Previous Clinical Trials
6,910,476 Total Patients Enrolled
9 Trials studying Atrial Fibrillation
1,117 Patients Enrolled for Atrial Fibrillation
National Heart, Lung, and Blood Institute (NHLBI)NIH
3,813 Previous Clinical Trials
47,290,846 Total Patients Enrolled
45 Trials studying Atrial Fibrillation
539,473 Patients Enrolled for Atrial Fibrillation
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