This trial is evaluating whether Treatment will improve 1 primary outcome and 5 other outcomes in patients with Aortic Valve Disease. Measurement will happen over the course of Up to 7 days, 6 months, 3 years and 5 years post implant.
This trial requires 363 total participants across 0 different treatment group
"Results from a recent paper has indicated a genetic component to AV disease; however, other factors like diet and hormones may also play a role; further investigation is needed." - Anonymous Online Contributor
"For patients with severe disease, aortic valve surgery is often curative of symptoms in patients older than 60 years of age. Early surgical intervention (within 30 days) is correlated with better early and mid-term survival of patients." - Anonymous Online Contributor
"around 20 million Americans will develop valve disease due to the aortic valve. There will be approximately 10,000 new cases of aortic valve disease in the United States in 2022." - Anonymous Online Contributor
"Most patients with aortic stenosis or regurgitation require surgical valve replacement. However, some patients with aortic stenosis or aortic stenosis and left ventricular dysfunction may be treated with catheter ablation of the accessory pathway, with success rates comparable to those of surgery, or may be treated with cardiac resynchronization therapy." - Anonymous Online Contributor
"Left ventricular dysfunction is common in adults 50 years of age or beyond. In adults with symptomatic aortic insufficiency or ascending aortic aneurysm, there must be a high index of suspicion for occult aortic valve disease (disease of the heart valves) such as rheumatic aortic stenosis. Aortic insufficiency should be treated by minimally invasive surgical aortic valve replacement because its long-term durability compares favorably with the bioprosthetic artificial valve. The incidence of ascending aortic aneurysm, however, is not known because routine screening is still not generally accepted; therefore, it is more likely that the incidence is relatively low." - Anonymous Online Contributor
"Aortic valve disease may present several symptoms because of obstruction to the outflow of blood from the left side of the heart. The main symptoms are dyspnea on exertion, cough, chest pain during coughing, and sudden unexplained weight loss. The first symptom of aortic valve stenosis that the physician encounters often is fatigue. Other specific, often more serious signs and symptoms include fainting or a sudden stop in breathing. All signs are due to obstruction to the outflow of blood. Most patients do not have these symptoms at an early stage of the disease." - Anonymous Online Contributor
"Based on the results of this study, treatment with ACEI/ARB was better than medical treatment alone in improving HRQOL. Although ACEI and ARB were equivalent in improving HRQOL, the use of ACEI or ARB was correlated with the treatment choice and age at the start of treatment and the clinical severity of the disease." - Anonymous Online Contributor
"Given a high probability of serious complications associated with surgical treatment, nonoperative care is recommended for degenerative disease of the aortic valve, as it remains as effective as surgical intervention when used in symptomatic patients. In symptomatic patients with normal mitral valves, surgical aortic valve replacement is recommended. However, surgical intervention is associated with significantly higher long-term mortality than nonoperative care in symptomatic patients with normal mitral valves." - Anonymous Online Contributor
"There has not been any breakthrough in treating aortic valve disease. Current research continues to seek to improve outcomes through better understanding of the pathologic processes responsible for aortic valve disease. Further clinical and preclinical research is underway to elucidate how specific molecules, and specific genes and pathways, influence valve disease progression and progression to cardiac valve replacement to improve outcomes and outcomes of the disease." - Anonymous Online Contributor
"There are very few national data on AVD; thus, the mean age of onset of AVD is difficult to identify from a single retrospective survey of a single referral region. Despite this caveat, it is reasonable to hypothesize that many patients have AVD diagnosed by age 60 and the average age of diagnosis for AVD is around 63 years." - Anonymous Online Contributor
"Data from a recent study, severe aortic stenosis was associated with low cardiac and renal event-free survival; advanced age, high New York Heart Association functional class, severe left ventricular dysfunction, and elevated pulmonary arterial pressures were predictive of a worse prognosis. Patients with severe aortic stenosis may benefit from treatment with aortic valve prosthesis." - Anonymous Online Contributor
"Patients are not generally being diagnosed and treated for an incidental finding of AS, and patients with AS are likely to be treated by surgeons who treat heart valve disease. The [Journal of Cardiovascular Surgery]'s annual ASCP meeting in 2010 [provided the opportunity to discuss some of this information with surgical colleagues and other healthcare professionals who can assist in diagnosing and treating AS] (http://jcs.asm.org/content/65%3A8%9A%90%9A%9C%9Adissection%2C.pdf)." - Anonymous Online Contributor