This trial is evaluating whether Isoproterenol will improve 2 primary outcomes and 4 secondary outcomes in patients with Anorexia Nervosa. Measurement will happen over the course of Immediately after drug/placebo infusion.
This trial requires 25 total participants across 2 different treatment groups
This trial involves 2 different treatments. Isoproterenol is the primary treatment being studied. Participants will all receive the same treatment. Some patients will receive a placebo treatment. The treatments being tested are not being studied for commercial purposes.
"The lack of a strong biological cause for AN is consistent with the existence of other psychiatric disorders, including BN, with more biological explanations of the etiology of anorexia nervosa." - Anonymous Online Contributor
"The degree to which anorexia is associated with bulimic symptoms is a significant predictor of remission of depressive symptoms among women. However, many women who report bulimic and anorexic symptomatology have never experienced either full-blown anorexia nervosa or bulimia nervosa. It appears, therefore, that at least part of the symptomatology of anorexia nervosa is independent of the full-blown form. Further research is required to evaluate whether these findings are due to sampling bias or whether they apply to women with full-blown or subthreshold anorexia nervosa." - Anonymous Online Contributor
"About 25,000 cases of anorexia nervosa are diagnosed a year in the United States. Eating disorders remain highly comorbid in both inpatient and outpatient populations." - Anonymous Online Contributor
"The treatments for AN are largely based on the assumption that the disorders are related to some underlying abnormality such as disordered eating and interpersonal motivation. Given that anorexia continues to be highly stigmatising in the modern socio-cultural context, future research is needed into the effectiveness of treatments for anorexia that do not assume a 'causative' aetiology in relation to social factors." - Anonymous Online Contributor
"Symptoms of anorexia nervosa typically appear when patients are young, around the age of 15 years. They include weight loss, fatigue, or the feeling that one is too thin. If the symptoms persist, the problem may be more serious, as individuals with anorexia have an increased risk of experiencing some consequences of starvation, such as depression, low birth weight, or death. Patients can therefore be questioned about physical anomalies, such as low body mass index (BMI), hair loss, and/or dental abnormalities. Other signs of the disease are loss of appetite, anxiety, and bulimia, as well as fear of gaining weight or being fat. There is also evidence of binge eating and eating disorders." - Anonymous Online Contributor
"The DSM-III was the first diagnosis classification in AN, but there was controversy from the psychiatric society in the inclusion criteria of AN. Most of the people suffering from AN, however, are not recognized by psychiatric health system, and many are not even recognized by medical health system. AN is highly under-recognized disorder, and we need to revise the diagnostic criteria of AN in the future." - Anonymous Online Contributor
"Isoproterenol as a first-generation beta-adrenoceptor agonist improved HRQoL in both ANR and ANL, but further research is needed to clarify whether isoproterenol as an additional treatment agent would improve HRQoL in patients with AN." - Anonymous Online Contributor
"Today, isoproterenol is no longer the drug of choice, but newer drugs are available. It is very important that any future randomized, placebo-controlled trials consider isoproterenol and compare them with the most recent medications." - Anonymous Online Contributor
"It seems that patients do fare better if they have their weight normalized as early as possible and the disorder is diagnosed as early as possible. Current psychotherapies are only slightly more effective than the 'no treatment' group, and the benefits are limited to long-term recovery. To date, no drug has been proven effective in treating the disorder; therefore, the use of psychotropic drugs remains the mainstay of treatment against AN." - Anonymous Online Contributor
"Isoproterenol is useful for the relief of chest pain for patients suffering from anorexia nervosa. It also inhibits the release of epinephrine in the case of the release of increased level of epinephrine in the condition." - Anonymous Online Contributor
"Although Ioproterenol is widely used in anorexia nervosa due to symptoms similar to the typical symptoms of angina, there are very few, if any, randomized studies regarding its safety. Furthermore, there are very few recorded cases of cardiopulmonary arrest without any other serious illnesses associated with the use of beta blockers. Thus, there is no evidence indicating that the use of isoproterenol is associated with a higher risk of death or serious injury. The benefits should be weighed against the risks of using beta blockers with this population." - Anonymous Online Contributor
"We found that about one in every five people with the disease dies from it. If [anorexia nervosa's consequences can be severe] it is time for you and your doctor to know enough about the disease [to manage it properly]." - Anonymous Online Contributor