CLINICAL TRIAL

Ethanol for Alcoholism

Recruiting · 18 - 65 · All Sexes · Gainesville, FL

This study is evaluating whether alcohol use is more effective for pain relief in people with a family history of alcoholism.

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About the trial for Alcoholism

Eligible Conditions
Alcoholism · Effects of Family History of Alcoholism and Sex on Alcohol Analgesia

Treatment Groups

This trial involves 2 different treatments. Ethanol is the primary treatment being studied. Participants will be divided into 2 treatment groups. Some patients will receive a placebo treatment. The treatments being tested are not being studied for commercial purposes.

Experimental Group 1
Ethanol
DRUG
+
Placebo
OTHER
Experimental Group 2
Ethanol
DRUG
+
Placebo
OTHER

About The Treatment

Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Ethanol
FDA approved

Eligibility

This trial is for patients born any sex between 18 and 65 years old. There is one eligibility criterion to participate in this trial as listed below.

Inclusion & Exclusion Checklist
Mark “yes” if the following statements are true for you:
- Consume at least 1 drink/month over the past 6 months
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Odds of Eligibility
Unknown<50%
Be sure to apply to 2-3 other trials, as you have a low likelihood of qualifying for this one.Apply To This Trial
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Approximate Timelines

Please note that timelines for treatment and screening will vary by patient
Screening: ~3 weeks
Treatment: varies
Reporting: Day 1; Day 2 (Laboratory sessions will be separated by at least 48 hours.)
This trial has approximate timelines as follows: 3 weeks for initial screening, variable treatment timelines, and reporting: Day 1; Day 2 (Laboratory sessions will be separated by at least 48 hours.).
View detailed reporting requirements
Trial Expert
Connect with the researchersHop on a 15 minute call & ask questions about:
- What options you have available- The pros & cons of this trial
- Whether you're likely to qualify- What the enrollment process looks like

Measurement Requirements

This trial is evaluating whether Ethanol will improve 6 primary outcomes in patients with Alcoholism. Measurement will happen over the course of Day 1; Day 2 (Laboratory sessions will be separated by at least 48 hours.).

Change in Connectivity of Pain-related Brain Regions during Painful Stimulation
DAY 1; DAY 2 (LABORATORY SESSIONS WILL BE SEPARATED BY AT LEAST 48 HOURS.)
Functional connectivity of brain regions involved in pain response
Change in Perceived Relief
DAY 1; DAY 2 (LABORATORY SESSIONS WILL BE SEPARATED BY AT LEAST 48 HOURS.)
Rating of relief from pain associated with consumption of the study beverage. VAS (visual analogue scale) assessing perceived relief anchored from "No relief at all" to "Most profound relief imaginable".
Change in Heat Pain Threshold
DAY 1; DAY 2 (LABORATORY SESSIONS WILL BE SEPARATED BY AT LEAST 48 HOURS.)
Temperature of heat stimulus applied to the foot at which participant reports pain. VAS (visual analogue scale) pain intensity and unpleasantness ratings anchored from "no pain at all"/"not at all unpleasant" to "most intense/unpleasant imaginable" will be collected.
Change in Heat Pain Ratings
DAY 1; DAY 2 (LABORATORY SESSIONS WILL BE SEPARATED BY AT LEAST 48 HOURS.)
Participant perception of pain at a temperature producing a pain rating of approximately 5 out of 10 at baseline. VAS (visual analogue scale) pain intensity ratings anchored from "no pain at all" to "most intense imaginable" will be collected.
Change in Heat Pain Tolerance
DAY 1; DAY 2 (LABORATORY SESSIONS WILL BE SEPARATED BY AT LEAST 48 HOURS.)
Temperature of heat stimulus applied to the foot at which participant no longer tolerates pain. VAS (visual analogue scale) pain intensity and unpleasantness ratings anchored from "no pain at all"/"not at all unpleasant" to "most intense/unpleasant imaginable" will be collected.
Change in Activity of Pain-related Brain Regions during Painful Stimulation
DAY 1; DAY 2 (LABORATORY SESSIONS WILL BE SEPARATED BY AT LEAST 48 HOURS.)
Functional activation of brain regions involved in pain response

Patient Q & A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many people get alcoholism a year in the United States?

About 35 million adults ages 18 or older in the US are found to be affected by alcoholism. This makes up more than 15% of Americans.\n

Anonymous Patient Answer

How serious can alcoholism be?

Alcoholism does not cause severe systemic problems. However, alcoholism is associated with a moderate, dose-related increase of mortality, particularly in those with liver disease, hypertension, and smoking. Alcoholism is a risk factor for ischemia, especially in the setting of atherosclerosis, with consequences potentially far larger than alcohol intoxication.

Anonymous Patient Answer

Can alcoholism be cured?

Although the vast majority of alcoholics are able to quit drinking, about 50% do not become sober. Those who achieve sobriety at the time of their initial diagnosis of alcoholism are at a much higher likelihood than those who do not achieve sobriety for the eventual resolution of an alcohol problem.

Anonymous Patient Answer

What is alcoholism?

The term alcoholism is also loosely applied to certain intoxicating beverages, and is used for alcoholic beverages in general to refer to their intoxicating properties. The most common alcoholic beverages (beer, hard, and wine) have alcohol content, while the alcoholic soft drinks contain no alcohol. Alcoholism is a chronic brain disorder characterized by cognitive problems, personality changes, and physical deterioration. Alcohol dependence is another problem related to alcoholism, it is characterized by a number of symptoms such as withdrawal symptoms when alcohol is stopped. The frequency and severity of these symptoms vary with each person. Alcoholism is the leading cause of mental illness in the United States and it is often present with addiction.

Anonymous Patient Answer

What are the signs of alcoholism?

Alcoholism may affect a person through a variety of routes, including the brain, liver and GI tract. These symptoms may include impaired judgment and/or social/emotional problems. Alcoholism can also cause or exacerbate many of the medical conditions for which symptoms can occur. In particular, alcohol can increase the risk for developing heart disease, liver disease, and cancer.\n\n- http://www.drs.aqc.

Anonymous Patient Answer

What causes alcoholism?

Alcoholism is a disease of brain neurons caused by a combination of neuroendocrine and neurophysiological problems, but no single factor can be identified. A number of factors, including lifestyle, the environment and genetics are likely to have different contributions. The process of causation is not simple and cannot be explained in terms of simplistic genes and environmental causes.

Anonymous Patient Answer

What are common treatments for alcoholism?

Alcoholism is often treated with medication or medical detoxification. In addition, alcoholics rarely receive comprehensive treatment which includes cognitive-behavioural therapy (CBT). Treatment often includes counselling for a lifetime, and usually some type of medical detoxification is required. Although there is not a clear evidence of increased risk of relapse for detoxification or medication/medication alone. Evidence indicates that alcoholism should be treated as a chronic disease and not just as a form of addiction. Alcoholics should be monitored to prevent relapse and medical issues relating to alcohol.\n\nThe following conditions are defined within the DSM-5.

Anonymous Patient Answer

Does alcoholism run in families?

It is possible that alcoholism can be inherited with high heritability coefficients. However, other aspects of alcoholism are more heritable than alcoholism per se. Alcoholism and obesity are highly comorbid. Thus, one should carefully consider other environmental causes before discounting heritability of alcoholism.

Anonymous Patient Answer

What is the latest research for alcoholism?

Alcoholism remains a controversial area of research. There are many possible treatments and theories of addiction, it's often misunderstood and misunderstood yet with a lot of hope. So if you are looking for the latest research on alcoholism, [Bupropion, naltrexone, rasagiline, clonidine, and topiramate] are all the most investigated treatments which have been proven to be effective. They are known to be effective alternatives to drug treatment.

Anonymous Patient Answer

Who should consider clinical trials for alcoholism?

Clinical investigators should consider patient characteristics before starting clinical trials. This information should be obtained at the pretrial evaluation and during the informed consent process, and include an assessment of patients' knowledge of risks and benefits of therapy, their motivation to improve the condition, and their willingness to try behavioral therapies.

Anonymous Patient Answer

What does ethanol usually treat?

[Ethanol treatments are used to treat alcoholism and various psychiatric disorders, including mood disorders, anxiety, psychosis, and psychosis in alcoholism, and chronic mood disorders such as depression and anxiety in alcoholism] The present study illustrates that ethanol is an anti-anxiety agent, which is not well understood at present. These studies will help elucidate the underlying psychoactive mechanisms of ethanol treatments.

Anonymous Patient Answer

Has ethanol proven to be more effective than a placebo?

Findings from a recent study seem to be in agreement with previous work suggesting that a large dose of ethanol is more effective than a placebo.

Anonymous Patient Answer
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