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Episodic Future Thinking for Alcohol Use Disorder (RP1A Trial)

N/A
Recruiting
Led By Warren K Bickel, PhD
Research Sponsored by Virginia Polytechnic Institute and State University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
21-65 years of age
Desire to quit or cut down on their drinking, but do not have proximate plans to enroll in treatment for AUD during the study period
Timeline
Screening 3 weeks
Treatment Varies
Follow Up pre-post intervention
Awards & highlights

RP1A Trial Summary

This trial is testing whether a method called episodic future thinking (EFT) can reduce alcohol self-administration in the laboratory, as well as reduce delay discounting and alcohol craving.

Who is the study for?
This trial is for adults aged 21-65 with alcohol use disorder who want to reduce their drinking but aren't planning on treatment during the study. They must enjoy a drink that's used in the study and not be pregnant, breastfeeding, or have brain injuries, seizures, severe drug disorders (except for alcohol, nicotine, marijuana), or psychotic disorders.Check my eligibility
What is being tested?
The trial tests Episodic Future Thinking (EFT) against Control Episodic Thinking (CET). EFT involves imagining positive future events in detail to potentially reduce immediate desire for alcohol. The effects on actual drinking behavior and brain activity related to decision-making and future planning will be studied.See study design
What are the potential side effects?
Since this intervention involves psychological exercises rather than medication, traditional side effects are not expected. However, participants may experience emotional discomfort while engaging in introspective thinking tasks.

RP1A Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am between 21 and 65 years old.
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I want to reduce or stop my drinking but don't plan to seek alcohol use disorder treatment soon.
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One of my top three preferred drinks is suitable for the study's alcohol task.
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I am between 21 and 65 years old.

RP1A Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~fmri session will occur at either session 2 or session 3 based on counterbalance assignment. s2 occurs up to 7 days post s1 and s3 occurs up to 7 days post s2.
This trial's timeline: 3 weeks for screening, Varies for treatment, and fmri session will occur at either session 2 or session 3 based on counterbalance assignment. s2 occurs up to 7 days post s1 and s3 occurs up to 7 days post s2. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in Alcohol Craving (Studies 1 and 2)
Change in Alcohol Demand (Studies 1 and 2)
Change in Delay Discounting (Studies 1 and 2)
+4 more

RP1A Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Episodic Future Thinking (EFT)Experimental Treatment1 Intervention
Participants will generate positive future events they are looking forward to at five time points in the future (1 day, 1 week, 1 month, 3 months, 1 year, 5 years, and 25 years). Participants will be reminded of these events using cues throughout the study and instructed to think about these cues as they make their decisions.
Group II: Control Episodic Thinking (CET)Placebo Group1 Intervention
Participants will generate positive recent past events that have happened to them at five time points in the recent past (last night from 7pm-10pm, yesterday between 4pm-7pm, yesterday between 1pm-4pm, yesterday from 10am-12pm, yesterday between 7am-10am, the night before last between 7pm-10pm, and evening before last between 4pm-7pm). Participants will be reminded of these events using cues throughout the study and instructed to think about these cues as they make their decisions.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Episodic Future Thinking
2018
N/A
~450

Find a Location

Who is running the clinical trial?

Carilion ClinicOTHER
70 Previous Clinical Trials
12,585 Total Patients Enrolled
1 Trials studying Alcoholism
112 Patients Enrolled for Alcoholism
Virginia Polytechnic Institute and State UniversityLead Sponsor
139 Previous Clinical Trials
27,494 Total Patients Enrolled
6 Trials studying Alcoholism
1,090 Patients Enrolled for Alcoholism
University of KentuckyOTHER
184 Previous Clinical Trials
226,436 Total Patients Enrolled
2 Trials studying Alcoholism
142 Patients Enrolled for Alcoholism

Media Library

Episodic Future Thinking Clinical Trial Eligibility Overview. Trial Name: NCT04125238 — N/A
Alcoholism Research Study Groups: Control Episodic Thinking (CET), Episodic Future Thinking (EFT)
Alcoholism Clinical Trial 2023: Episodic Future Thinking Highlights & Side Effects. Trial Name: NCT04125238 — N/A
Episodic Future Thinking 2023 Treatment Timeline for Medical Study. Trial Name: NCT04125238 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is there an upper age limit for participation in this experiment?

"This research trial is seeking participants aged 21 to 65. If the patient does not meet this age criteria, there are alternative options with 34 trials for those under 18 and 249 for persons over 65."

Answered by AI

Are there still spots available for individuals to join this experiment?

"Affirmative, clinicaltrials.gov has information that suggests the current recruitment of subjects for this clinical trial. It was issued on November 13th 2020 and latest modified June 28th 2022; 130 individuals are needed to join from a single location."

Answered by AI

Am I eligible to participate in this trial?

"This clinical trial seeks 130 high-risk drinkers, aged between 21 and 65, who are not looking to enrol in alcohol treatment programs during their participation. Participants must have an AUDIT score indicating harmful drinking habits, a desire to reduce consumption of alcohol, and one of their top three preferred drinks should be appropriate for the self-administration task (Study 1)."

Answered by AI

How many participants are being accepted to partake in this experiment?

"Affirmative. Clinicaltrials.gov records show that this trial, first posted on November 13th 2020, is actively recruiting patients at one location and seeking 130 individuals in total."

Answered by AI

Who else is applying?

What state do they live in?
Virginia
How old are they?
18 - 65
What site did they apply to?
Fralin Biomedical Research Institute at VTC
What portion of applicants met pre-screening criteria?
Met criteria
~22 spots leftby Nov 2024