Episodic Future Thinking for Alcoholism

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Fralin Biomedical Research Institute at VTC, Roanoke, VAAlcoholismEpisodic Future Thinking - Behavioral
Eligibility
21 - 65
All Sexes
What conditions do you have?
Select

Study Summary

This trial is testing whether a method called episodic future thinking (EFT) can reduce alcohol self-administration in the laboratory, as well as reduce delay discounting and alcohol craving.

Eligible Conditions
  • Alcoholism

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

13 Primary · 0 Secondary · Reporting Duration: fMRI session will occur at either Session 2 or Session 3 based on counterbalance assignment. S2 occurs up to 7 days post S1 and S3 occurs up to 7 days post S2.

Day 7
Change in Alcohol Craving
Change in Alcohol Craving (Studies 1 and 2)
Change in Alcohol Demand
Change in Alcohol Demand (Studies 1 and 2)
Change in Delay Discounting
Change in Delay Discounting (Studies 1 and 2)
Day 7
In-Laboratory Alcohol Consumption
In-Laboratory Alcohol Consumption (Study 1)
Day 7
Neural activation during fMRI alcohol purchase task
Neural activation during fMRI alcohol purchase task (Study 1)
Neural activation during fMRI delay discounting task
Neural activation during fMRI delay discounting task (Study 1)
pre-post intervention
Change in alcoholic drinks per day (Study 2)

Trial Safety

Safety Progress

1 of 3

Trial Design

2 Treatment Groups

Episodic Future Thinking (EFT)
1 of 2
Control Episodic Thinking (CET)
1 of 2

Experimental Treatment

Non-Treatment Group

130 Total Participants · 2 Treatment Groups

Primary Treatment: Episodic Future Thinking · Has Placebo Group · N/A

Episodic Future Thinking (EFT)
Behavioral
Experimental Group · 1 Intervention: Episodic Future Thinking · Intervention Types: Behavioral
Control Episodic Thinking (CET)
Behavioral
ShamComparator Group · 1 Intervention: Control Episodic Thinking · Intervention Types: Behavioral
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Episodic Future Thinking
2018
N/A
~240

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: fmri session will occur at either session 2 or session 3 based on counterbalance assignment. s2 occurs up to 7 days post s1 and s3 occurs up to 7 days post s2.

Who is running the clinical trial?

Carilion ClinicOTHER
67 Previous Clinical Trials
12,190 Total Patients Enrolled
1 Trials studying Alcoholism
88 Patients Enrolled for Alcoholism
Virginia Polytechnic Institute and State UniversityLead Sponsor
118 Previous Clinical Trials
26,406 Total Patients Enrolled
4 Trials studying Alcoholism
964 Patients Enrolled for Alcoholism
University of KentuckyOTHER
173 Previous Clinical Trials
225,476 Total Patients Enrolled
1 Trials studying Alcoholism
88 Patients Enrolled for Alcoholism
McMaster UniversityOTHER
820 Previous Clinical Trials
1,731,605 Total Patients Enrolled
2 Trials studying Alcoholism
168 Patients Enrolled for Alcoholism
National Institute on Alcohol Abuse and Alcoholism (NIAAA)NIH
729 Previous Clinical Trials
1,338,163 Total Patients Enrolled
382 Trials studying Alcoholism
978,435 Patients Enrolled for Alcoholism
Arizona State UniversityOTHER
248 Previous Clinical Trials
89,095 Total Patients Enrolled
1 Trials studying Alcoholism
88 Patients Enrolled for Alcoholism
Warren K Bickel, PhDPrincipal InvestigatorFralin Biomedical Research Institute at VTC
8 Previous Clinical Trials
1,068 Total Patients Enrolled
3 Trials studying Alcoholism
282 Patients Enrolled for Alcoholism
Stephen M LaConte, PhDPrincipal InvestigatorFralin Biomedical Research Institute at VTC
2 Previous Clinical Trials
188 Total Patients Enrolled
2 Trials studying Alcoholism
188 Patients Enrolled for Alcoholism

Eligibility Criteria

Age 21 - 65 · All Participants · 4 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
You prefer to drink an alcoholic beverage that will be provided during the study.
You want to reduce your alcohol intake, but are not planning to seek treatment for alcohol use disorder during the study.

Who else is applying?

What state do they live in?
Virginia100.0%
How old are they?
18 - 65100.0%
What site did they apply to?
Fralin Biomedical Research Institute at VTC100.0%
What portion of applicants met pre-screening criteria?
Met criteria100.0%

Frequently Asked Questions

Is there an upper age limit for participation in this experiment?

"This research trial is seeking participants aged 21 to 65. If the patient does not meet this age criteria, there are alternative options with 34 trials for those under 18 and 249 for persons over 65." - Anonymous Online Contributor

Unverified Answer

Are there still spots available for individuals to join this experiment?

"Affirmative, clinicaltrials.gov has information that suggests the current recruitment of subjects for this clinical trial. It was issued on November 13th 2020 and latest modified June 28th 2022; 130 individuals are needed to join from a single location." - Anonymous Online Contributor

Unverified Answer

Am I eligible to participate in this trial?

"This clinical trial seeks 130 high-risk drinkers, aged between 21 and 65, who are not looking to enrol in alcohol treatment programs during their participation. Participants must have an AUDIT score indicating harmful drinking habits, a desire to reduce consumption of alcohol, and one of their top three preferred drinks should be appropriate for the self-administration task (Study 1)." - Anonymous Online Contributor

Unverified Answer

How many participants are being accepted to partake in this experiment?

"Affirmative. Clinicaltrials.gov records show that this trial, first posted on November 13th 2020, is actively recruiting patients at one location and seeking 130 individuals in total." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.