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Blood Volume Analysis for Heart Failure
N/A
Waitlist Available
Led By Wayne Miller, MD
Research Sponsored by Mayo Clinic
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Age > 18 years
LVEF <50% measured within 6 months of index hospitalization
Timeline
Screening 3 weeks
Treatment Varies
Follow Up hospital admission through hospital discharge, approximately 6 days
Awards & highlights
Study Summary
This trial is observing if proEnkephalin (PENK) values in blood can predict changes in kidney function in hospitalized patients that need diuretic treatment.
Eligible Conditions
- Heart Failure
- Volume Overload
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ hospital admission through hospital discharge, approximately 6 days
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~hospital admission through hospital discharge, approximately 6 days
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Assessment of ProEnkephalin to detect acute kidney injury in hospitalized to identify baseline values of PENK biomarkers of AKI in relation to measured intravascular volume.
Trial Design
1Treatment groups
Experimental Treatment
Group I: Subjects with know chronic systolic heart failureExperimental Treatment2 Interventions
Subjects with know chronic systolic heart failure (LVEF<50%) admitted to SMH Heart Failure Medical Service for decompensated HF with clinical findings of volume overload requiring advanced diuretic therapy intervention and management will receive daily blood draws and quantitative blood volume analysis
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Blood Collection
2014
Completed Phase 4
~7010
Blood Volume Analysis
2019
N/A
~20
Find a Location
Who is running the clinical trial?
Mayo ClinicLead Sponsor
3,175 Previous Clinical Trials
3,758,141 Total Patients Enrolled
72 Trials studying Heart Failure
1,022,046 Patients Enrolled for Heart Failure
Sphingotec GmbHIndustry Sponsor
1 Previous Clinical Trials
596 Total Patients Enrolled
Wayne Miller, MDPrincipal InvestigatorMayo Clinic
Frequently Asked Questions
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