Treatment for Fluid Loss

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Vitalant Blood Donation, Denver, CO
Fluid Loss
Eligibility
18+
All Sexes
Eligible conditions
Select

Study Summary

This study is evaluating whether a cardiac monitor can be used to characterize changes in the relative index during an apheresis donation procedure.

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Treatment Effectiveness

Study Objectives

This trial is evaluating whether Treatment will improve 1 primary outcome and 4 secondary outcomes in patients with Fluid Loss. Measurement will happen over the course of 1-6 hours.

1-6 hours
Characterize changes in blood pressure relative to changes in the Relative Index
Characterize changes in the Relative Index during an apheresis procedure
Characterize changes in the Relative Index in right and left antecubital donations
Characterize relative Index changes when using various apheresis devices
Characterize the CM-1500's ability to detect different blood components and fluid

Trial Safety

Trial Design

0 Treatment Group

This trial requires 200 total participants across 0 different treatment group

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 1-6 hours
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly 1-6 hours for reporting.

Closest Location

Vitalant Blood Donation - Denver, CO

Eligibility Criteria

This trial is for patients born any sex aged 18 and older. There are 4 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
The ability and willingness to comply with the study procedures and duration requirements is necessary for participation in this study. show original
An adult is someone who is 18 years of age or older. show original
I agreed to have a blood component procedure using an automated device. show original
The ability to provide written informed consent is important because it allows people to make decisions about their own health care show original

Patient Q&A Section

How many people get fluid loss a year in the United States?

"In 2012 the American Medical Association estimated that 25 million Americans lost a minimum of 8.9 cubic meters of fluid per year, or approximately 2.2 trillion liters (or approximately 5.1 trillion US gallons) of fluid." - Anonymous Online Contributor

Unverified Answer

What causes fluid loss?

"Patients with edentulism are more susceptible to fluid loss from osmolality alterations because of a higher osmolality in oral cavity than in extra-oral cavity after oral sugar ingestion. Fluid loss from osmolality alterations might be a potential cause of chronic edentulism." - Anonymous Online Contributor

Unverified Answer

What is fluid loss?

"Fluid loss is defined as any loss of body water and solutes. Fluid loss occurs as a result of: water loss via insensible sweating, urine losses, and in respiration.\n" - Anonymous Online Contributor

Unverified Answer

What are the signs of fluid loss?

"Symptoms of fluid loss include decreased urine output, urinary frequency, an empty bladder, constipation or urgency to urinate, and a dry mouth. There may also be a weight loss of 5 to 10% within 24 hours. These symptoms can last more than 24 hours, and can begin when fluid is first lost as a result of vomiting or diarrhea.\n\nSigmoidoscopy is used in the diagnosis of malignant bowel disease such as colonic carcinoma (cancer of the colon or intestines).\n\nSigmoidoscopy consists of the passage of a thin, scope-like tube along the colon in an attempt to detect cancerous tumors by means of looking at the inside of the colon." - Anonymous Online Contributor

Unverified Answer

What are common treatments for fluid loss?

"Some fluid losses result from diarrhea, sweating, vomiting or malabsorption. Diarrhea, vomiting, and fluid replacement are treatments often recommended in the management of dehydration. Other treatment options for fluid loss include dietary salt restriction to reduce sodium intake and the drug loop diuretic to constrict the kidney tubes. Surgical repair of a ureteral obstruction can reduce urine output and result in the need for fluid replacement." - Anonymous Online Contributor

Unverified Answer

Can fluid loss be cured?

"Total fluid loss appears to be a significant predictor for the severity and duration of vomiting. In the majority of patients, improvement in patients' status can be achieved by correcting the fluid balance instead of relying on vomiting alone. However, a significant proportion of patients with massive vomiting will not benefit if the fluid balance is adjusted inappropriately. Thus, a careful determination of fluid losses is required prior to volume replacement." - Anonymous Online Contributor

Unverified Answer

What is the primary cause of fluid loss?

"Patients with low volume of total body fluid (TBF) are more likely to have low volume of urine fluid loss (UVFL). Most of UVFL is due to the diuresis. Thus UVFL in turn is associated with low volume of TBF, which is the primary cause of UVFL. Therefore it should be considered as a complication of low volume of TBF." - Anonymous Online Contributor

Unverified Answer

Is treatment typically used in combination with any other treatments?

"In order to improve the quality of patient care, treatment in combination with other treatments is often needed in different departments, such as the neurology, the anesthesiology and the surgery departments in our institution. The necessity and the extent of these treatments varies. Hence, treatment in combination is a complicated and challenging issue." - Anonymous Online Contributor

Unverified Answer

What is the average age someone gets fluid loss?

"In the present population, average fluid loss was found to be 64 mm, a bit higher than expected. There are three causes: 1.) people age >70 years are more prone to severe dehydration because of many physiological changes associated with ageing (e.g. increased urinary loss, decreased blood volume etc.), and therefore are more prone to dehydration due to an increase in the risk for illness; 2.) people aged 90–99 years are more prone to dehydration because of the increased risk of dehydration from the reduced activity and lower caloric expenditure; and 3." - Anonymous Online Contributor

Unverified Answer

What is treatment?

"People with IBS and FDD commonly perceive improvement of disease on medication and also on exercise, both of which provide direct therapeutic benefit by alleviating symptoms and alleviating disability. Data from a recent study shows that those with IBS and FDD frequently report on benefit from other therapies. As well, both FDD and IBS patients experience benefit from therapies that address co-morbid psychiatric symptoms. Further study is warranted." - Anonymous Online Contributor

Unverified Answer

Have there been other clinical trials involving treatment?

"A wide variety of topical and oral treatments have been investigated by clinical trials but are no longer on the market. The evidence for these treatments is not strong." - Anonymous Online Contributor

Unverified Answer

What is the latest research for fluid loss?

"As of February 2011, the total number of research questions about fluid balance has exceeded 4000, indicating how much research activity there is. Some current research investigates fluid balance during dialysis, others focuses on fluid balance and fluid retention, others on the effects of fluids on health, and the rest in other fields. There is information about fluid balance in medical literature but there is no summary or literature review of the fluid balance literature. As a first step, it is important to summarize the literature about fluid balance because this will permit doctors, nurses and lay persons to make appropriate fluid management decisions. A series of systematic reviews on fluid balance was published in 2010. This review was the first systematic review of the literature on fluid balance." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
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