CLINICAL TRIAL

Palliative Care Intervention for Hematopoietic Stem Cell Transplantation (SCT)

Recruiting · 18+ · All Sexes · Seattle, WA

This study is evaluating whether a team of doctors who specialize in treating symptoms of cancer and its treatment may help improve quality of life and mood for patients undergoing stem cell transplantation. original

See full description

About the trial for Hematopoietic Stem Cell Transplantation (SCT)

Treatment Groups

This trial involves 2 different treatments. Palliative Care Intervention is the primary treatment being studied. Participants will be divided into 2 treatment groups. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Experimental Group 1
Standard Transplant Care
OTHER
Experimental Group 2
Palliative Care Intervention
OTHER

Eligibility

This trial is for patients born any sex aged 18 and older. There are 5 eligibility criteria to participate in this trial as listed below.

Inclusion & Exclusion Checklist
Mark “yes” if the following statements are true for you:
ability to read and respond to questions in English or Spanish or to complete questionnaires with assistance from an interpreter. show original
An adult relative or friend of a patient who is at least 18 years old and agrees to participate in the study, whom the patient has identified as living with them or having in-person contact with them at least twice per week. show original
Patient Inclusion Criteria
People aged 18 or over who have a hematologic malignancy and are admitted for autologous or allogeneic HCT. show original
capability to read and answer inquiries in English or Spanish or to finish questionnaires with the help of an interpreter. show original
View All
Odds of Eligibility
Unknown<50%
Be sure to apply to 2-3 other trials, as you have a low likelihood of qualifying for this one.Apply To This Trial
Similar Trials

Approximate Timelines

Please note that timelines for treatment and screening will vary by patient
Screening: ~3 weeks
Treatment: varies
Reporting: up to 1 year
Screening: ~3 weeks
Treatment: Varies
Reporting: up to 1 year
This trial has approximate timelines as follows: 3 weeks for initial screening, variable treatment timelines, and reporting: up to 1 year.
View detailed reporting requirements
Trial Expert
Connect with the researchersHop on a 15 minute call & ask questions about:
- What options you have available- The pros & cons of this trial
- Whether you're likely to qualify- What the enrollment process looks like

Measurement Requirements

This trial is evaluating whether Palliative Care Intervention will improve 1 primary outcome, 9 secondary outcomes, and 4 other outcomes in patients with Hematopoietic Stem Cell Transplantation (SCT). Measurement will happen over the course of 2 weeks.

Patient-reported quality of life (QOL): Functional Assessment of Cancer Therapy - Bone Marrow Transplant (FACT-BMT)
2 WEEKS
Compare patient QOL using the Functional Assessment of Cancer Therapy- Bone Marrow Transplant (FACT-BMT) scores at week 2 between the study groups Score range 0-164 with higher score indicating better quality of life
2 WEEKS
Moderation analysis to examine whether patient or transplant related characteristics are moderators of the effect of the intervention on patient-reported QOL
2 WEEK
moderation analysis (moderation analyses are common in these types of studies. there is no new novel outcome measure here, bur rather examining moderation)
2 WEEK
mediation analysis (symptom burden and coping) as mediators of improvement in patient-reported QOL
2 WEEK
mediation analysis (mediation analyses are common in these types of studies, there is no novel new outcome measure here, but rather examining mediation)
2 WEEK
Patients' post-traumatic stress symptoms (PTSD)
UP TO 1 YEARS
Compare patients' post-traumatic stress symptoms using the PTSD Checklist- Civilian version (PCL-C) between the study groups PCL-C score ranges from 17-85 with higher scores indicating worse PTSD symptoms
UP TO 1 YEARS
Patients' psychological distress
UP TO 1 YEARS
Compare patients' depression and anxiety symptoms using the Hospital Anxiety and Depression Scale (HADS) between the study groups The HADS consists of two subscales assessing depression and anxiety symptoms, with scores ranging from 0 (no distress) to 21 (maximum distress)
UP TO 1 YEARS
Patients' fatigue
UP TO 1 YEARS
Compare patients' fatigue using Functional Assessment of Cancer Therapy- Fatigue (FACT-fatigue) scores between the study groups score range from 0-52 with higher scores indicating lower fatigue symptoms
UP TO 1 YEARS
See More

Who is running the study

Principal Investigator
E. A.
El-Jawahri Areej,M.D., Principal Investigator
Massachusetts General Hospital

Patient Q & A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are common treatments for hematopoietic stem cell transplantation (sct)?

In the current era of stem cell transplantation, both allogeneic (allogenic) transplants and autologous (autologous) transplants are used. Allogeneic transplants are performed because they are perceived as the most reliable option. Sustained engraftment is achievable with a wide variety of transplants. Autologous transplants are less efficacious. Although the data to support either type of procedure have limitations, both are highly effective with acceptable toxicity. This guideline was developed after systematic review to guide clinicians as to the optimal approach to both high-risk and low-risk HCT.

Anonymous Patient Answer

What are the signs of hematopoietic stem cell transplantation (sct)?

The initial signs of sct are nausea and vomiting, which usually disappear within 2 hours. It may also cause a slight fever. Signs of graft-versus-host disease include rash, fever, and lower-back or abdominal pain, typically in the first few weeks after the conditioning. Severe thrombocytopenia may be present 5 to 7 days after the transplant, and it can take as long as 4 to 6 weeks for neutrophil counts to begin rising. Severe graft-versus-host disease with skin necrosis is common among patients with acute lymphoblastic leukemia.

Anonymous Patient Answer

Can hematopoietic stem cell transplantation (sct) be cured?

There is no cure for SCT. Symptoms related to SCT can be reduced in more patients than not, but not eliminated. This is particularly true for patients free of symptoms at the time of initial SCT. To minimize the symptoms of SCT, early intervention into the treatment options for these patients has proven to be the most successful approach.

Anonymous Patient Answer

What is hematopoietic stem cell transplantation (sct)?

The bone marrow is a small container that holds the blood cells and gives them freshness, and is used to carry out certain operations to restore health. SCT can be performed on patients who would otherwise die after undergoing an operation to repair their bone marrow. SCT is a procedure that destroys healthy cells to replace those that have been damaged by a patient's disease. Hematopoietic stem cell transplantation, also called bone marrow transplantation, can be used in treatments that replace healthy blood cells. Hematopoietic stem cell transplantation is used in treatments that replace healthy blood cells. Hematopoietic stem cells are the cells that give rise to blood as well as lymphoid and myeloid cells.

Anonymous Patient Answer

How many people get hematopoietic stem cell transplantation (sct) a year in the United States?

HSCT patients receive on average 6.2 transplants per year in the United States. HSCT does represent a major medical and financial challenge to the US healthcare system. As the complexity of HSCT increases, our understanding of optimal patient selection and pre-treatment care is imperative. We encourage clinicians to continue to be vigilant in the search for effective transplantation strategies to improve post-HSCT quality of life and translate this knowledge into improved transplant outcomes.

Anonymous Patient Answer

What causes hematopoietic stem cell transplantation (sct)?

These studies have shown that the immune system plays a role in this transplantation procedure, and that some of the factors that influence a successful transplantation probably are genetic. In conclusion, immunosuppressants must not be forgotten in transplants.

Anonymous Patient Answer

Have there been other clinical trials involving palliative care intervention?

Although the evidence base for palliative care interventions in general is small, there is a wide-range of clinical trials reported in the literature which support the use of palliative care interventions in patients with non-malignant diseases. Clinical trials have the potential to dramatically improve palliative care by providing a solid evidence base for which to choose palliative care interventions that are appropriate in specific contexts for patients with various non-malignant diseases.

Anonymous Patient Answer

What are the common side effects of palliative care intervention?

Palliative care provides effective intervention for improving a patient's quality of life but can result in various physical, psychosocial and spiritual challenges in the individual, family and society. Physicians can make a contribution to mitigating the physical, psychosocial and spiritual challenges of the care of palliative patients by managing pain and symptoms, reducing fear and anxiety, improving nutrition, enhancing the quality of life and enhancing the patient and family's knowledge and skills in dealing with the palliative care challenges.

Anonymous Patient Answer

What is the latest research for hematopoietic stem cell transplantation (sct)?

Scientists are studying stem cells that might be helpful in treating blood diseases, especially with a condition called acute myeloid leukemia. Currently, one treatment option is called bone marrow transplantation (sct), but this procedure can have side effects and complications. A second treatment option is called hematopoietic stem cell transplantation. A positive response has been found if patients with both hematolytic and myelocytic disorders undergo bone marrow transplantation.

Anonymous Patient Answer

Is palliative care intervention safe for people?

It may be possible to help a person to make advance care planning on a continuum, with people having advanced palliative care support early in the disease course, as part of ongoing care. Supportive psychosocial interventions such as [buddies;https://www.buddies.org/ are a reasonable resource under limited resources and may be beneficial to people.

Anonymous Patient Answer

What is palliative care intervention?

There are many patients requiring a palliative option. However, the quality of care, whether palliative or curative, was very poor. A palliative option may help shorten aggressive interventions, but whether it should be curative is debatable.

Anonymous Patient Answer

What does palliative care intervention usually treat?

For the treatments, usual care represents a major limitation. The lack of standardized care is related, in part, to the palliative care philosophy of the institution and the lack of clear medical practice guidelines.

Anonymous Patient Answer
See if you qualify for this trial
Get access to this novel treatment for Hematopoietic Stem Cell Transplantation (SCT) by sharing your contact details with the study coordinator.