Palliative Care Intervention for Hematopoietic Stem Cell Transplantation (SCT)
This study is evaluating whether a team of doctors who specialize in treating symptoms of cancer and its treatment may help improve quality of life and mood for patients undergoing stem cell transplantation. original
See full descriptionAbout the trial for Hematopoietic Stem Cell Transplantation (SCT)
Treatment Groups
This trial involves 2 different treatments. Palliative Care Intervention is the primary treatment being studied. Participants will be divided into 2 treatment groups. There is no placebo group. The treatments being tested are not being studied for commercial purposes.
Eligibility
This trial is for patients born any sex aged 18 and older. There are 5 eligibility criteria to participate in this trial as listed below.
Approximate Timelines
Measurement Requirements
This trial is evaluating whether Palliative Care Intervention will improve 1 primary outcome, 9 secondary outcomes, and 4 other outcomes in patients with Hematopoietic Stem Cell Transplantation (SCT). Measurement will happen over the course of 2 weeks.
Who is running the study
Principal InvestigatorPatient Q & A Section
What are common treatments for hematopoietic stem cell transplantation (sct)?
In the current era of stem cell transplantation, both allogeneic (allogenic) transplants and autologous (autologous) transplants are used. Allogeneic transplants are performed because they are perceived as the most reliable option. Sustained engraftment is achievable with a wide variety of transplants. Autologous transplants are less efficacious. Although the data to support either type of procedure have limitations, both are highly effective with acceptable toxicity. This guideline was developed after systematic review to guide clinicians as to the optimal approach to both high-risk and low-risk HCT.
What are the signs of hematopoietic stem cell transplantation (sct)?
The initial signs of sct are nausea and vomiting, which usually disappear within 2 hours. It may also cause a slight fever. Signs of graft-versus-host disease include rash, fever, and lower-back or abdominal pain, typically in the first few weeks after the conditioning. Severe thrombocytopenia may be present 5 to 7 days after the transplant, and it can take as long as 4 to 6 weeks for neutrophil counts to begin rising. Severe graft-versus-host disease with skin necrosis is common among patients with acute lymphoblastic leukemia.
Can hematopoietic stem cell transplantation (sct) be cured?
There is no cure for SCT. Symptoms related to SCT can be reduced in more patients than not, but not eliminated. This is particularly true for patients free of symptoms at the time of initial SCT. To minimize the symptoms of SCT, early intervention into the treatment options for these patients has proven to be the most successful approach.
What is hematopoietic stem cell transplantation (sct)?
The bone marrow is a small container that holds the blood cells and gives them freshness, and is used to carry out certain operations to restore health. SCT can be performed on patients who would otherwise die after undergoing an operation to repair their bone marrow. SCT is a procedure that destroys healthy cells to replace those that have been damaged by a patient's disease. Hematopoietic stem cell transplantation, also called bone marrow transplantation, can be used in treatments that replace healthy blood cells. Hematopoietic stem cell transplantation is used in treatments that replace healthy blood cells. Hematopoietic stem cells are the cells that give rise to blood as well as lymphoid and myeloid cells.
How many people get hematopoietic stem cell transplantation (sct) a year in the United States?
HSCT patients receive on average 6.2 transplants per year in the United States. HSCT does represent a major medical and financial challenge to the US healthcare system. As the complexity of HSCT increases, our understanding of optimal patient selection and pre-treatment care is imperative. We encourage clinicians to continue to be vigilant in the search for effective transplantation strategies to improve post-HSCT quality of life and translate this knowledge into improved transplant outcomes.
What causes hematopoietic stem cell transplantation (sct)?
These studies have shown that the immune system plays a role in this transplantation procedure, and that some of the factors that influence a successful transplantation probably are genetic. In conclusion, immunosuppressants must not be forgotten in transplants.
Have there been other clinical trials involving palliative care intervention?
Although the evidence base for palliative care interventions in general is small, there is a wide-range of clinical trials reported in the literature which support the use of palliative care interventions in patients with non-malignant diseases. Clinical trials have the potential to dramatically improve palliative care by providing a solid evidence base for which to choose palliative care interventions that are appropriate in specific contexts for patients with various non-malignant diseases.
What are the common side effects of palliative care intervention?
Palliative care provides effective intervention for improving a patient's quality of life but can result in various physical, psychosocial and spiritual challenges in the individual, family and society. Physicians can make a contribution to mitigating the physical, psychosocial and spiritual challenges of the care of palliative patients by managing pain and symptoms, reducing fear and anxiety, improving nutrition, enhancing the quality of life and enhancing the patient and family's knowledge and skills in dealing with the palliative care challenges.
What is the latest research for hematopoietic stem cell transplantation (sct)?
Scientists are studying stem cells that might be helpful in treating blood diseases, especially with a condition called acute myeloid leukemia. Currently, one treatment option is called bone marrow transplantation (sct), but this procedure can have side effects and complications. A second treatment option is called hematopoietic stem cell transplantation. A positive response has been found if patients with both hematolytic and myelocytic disorders undergo bone marrow transplantation.
Is palliative care intervention safe for people?
It may be possible to help a person to make advance care planning on a continuum, with people having advanced palliative care support early in the disease course, as part of ongoing care. Supportive psychosocial interventions such as [buddies;https://www.buddies.org/ are a reasonable resource under limited resources and may be beneficial to people.
What is palliative care intervention?
There are many patients requiring a palliative option. However, the quality of care, whether palliative or curative, was very poor. A palliative option may help shorten aggressive interventions, but whether it should be curative is debatable.
What does palliative care intervention usually treat?
For the treatments, usual care represents a major limitation. The lack of standardized care is related, in part, to the palliative care philosophy of the institution and the lack of clear medical practice guidelines.