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Heat therapy for Endothelial Dysfunction

N/A
Waitlist Available
Led By Maureen J MacDonald, PhD
Research Sponsored by McMaster University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
18-35 years old
Apparently healthy (i.e., no cardiovascular, musculoskeletal, or metabolic disease)
Timeline
Screening 3 weeks
Treatment Varies
Follow Up change in arterial stiffness from week 0 to 8
Awards & highlights

Study Summary

Artery Function Responses to Heat Therapy and Exercise Training

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~change in endothelial function from week 0 to 8
This trial's timeline: 3 weeks for screening, Varies for treatment, and change in endothelial function from week 0 to 8 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Arterial stiffness
Structure of brachial artery
Secondary outcome measures
Body composition
Cardiorespiratory fitness
Core temperature
+4 more

Trial Design

4Treatment groups
Experimental Treatment
Active Control
Group I: Heat therapyExperimental Treatment1 Intervention
Participants will be asked to undergo 45 minutes of lower limb hot water immersion (42 degrees C) 3 times per week for 8 weeks.
Group II: Exercise trainingExperimental Treatment1 Intervention
Participants will be asked to undergo 45 minutes of moderate-intensity cycling exercise (~40-59% VO2 reserve) 3 times per week for 8 weeks.
Group III: Combined trainingExperimental Treatment2 Interventions
Participants will be asked to undergo 90 minutes of moderate-intensity cycling exercise and lower limb hot water immersion sequentially 3 times per week for 8 weeks.
Group IV: ControlActive Control1 Intervention
Participants will be asked to maintain their regular physical activity habits for the duration of the 8-week intervention period.

Find a Location

Who is running the clinical trial?

McMaster UniversityLead Sponsor
876 Previous Clinical Trials
2,595,940 Total Patients Enrolled
3 Trials studying Endothelial Dysfunction
46 Patients Enrolled for Endothelial Dysfunction
Maureen J MacDonald, PhDPrincipal InvestigatorMcMaster University
3 Previous Clinical Trials
46 Total Patients Enrolled
3 Trials studying Endothelial Dysfunction
46 Patients Enrolled for Endothelial Dysfunction

Frequently Asked Questions

~16 spots leftby Mar 2025