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Computed Tomography Perfusion Imaging for Pancreatic Cancer

N/A
Waitlist Available
Led By Ryan O'Malley
Research Sponsored by University of Washington
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
A diagnosis of pancreatic ductal adenocarcinoma
Signed informed consent form
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 4 years
Awards & highlights

Study Summary

This trial uses CT images to see how well a tumor responds to chemo/radiation, which may help guide treatment for pancreatic cancer patients.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~at 2 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and at 2 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in CT tumor perfusion parameter (Ktrans)
Change in CT tumor perfusion parameter (blood flow)
Change in CT tumor perfusion parameter (blood volume)
+5 more

Side effects data

From 2018 Phase 2 trial • 22 Patients • NCT02101918
77%
Hypertension
68%
Headache
45%
Mucositis oral
41%
Hoarseness
32%
Proteinuria
27%
Fatigue
23%
Constipation
23%
Nausea
23%
Abdominal pain
23%
Vomiting
18%
Alanine aminotransferase increased
18%
Diarrhea
18%
Arthralgia
14%
Neutrophil count decreased
14%
Creatinine increased
14%
Anorexia
14%
Pain
14%
Palmar-plantar erythrodysesthesia syndrome
14%
Epistaxis
14%
Weight loss
14%
Aspartate aminotransferase increased
14%
Platelet count decreased
14%
Anemia
9%
Sinusitis
5%
Dehydration
5%
Upper gastrointestinal hemorrhage
5%
cholecystitis
5%
Hemorrhage Upper GI
5%
Pain Abdominal
100%
80%
60%
40%
20%
0%
Study treatment Arm
Aflibercept 6 mg /kg IV

Trial Design

1Treatment groups
Experimental Treatment
Group I: Diagnostic (CT perfusion sequence)Experimental Treatment1 Intervention
Patients undergo CT perfusion sequence during the first 40 seconds of the baseline standard of care CT scan and during follow-up CT scans at 2 and possibly 4 months after chemotherapy, at 4-6 weeks after radiation therapy, or prior to definitive surgery.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Computed Tomography Perfusion Imaging
2016
Completed Phase 2
~90

Find a Location

Who is running the clinical trial?

University of WashingtonLead Sponsor
1,728 Previous Clinical Trials
1,840,859 Total Patients Enrolled
Ryan O'MalleyPrincipal InvestigatorFred Hutch/University of Washington Cancer Consortium

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
~9 spots leftby Mar 2025