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Anticholinergic
Anticholinergic for Overactive Bladder
Phase 4
Waitlist Available
Led By Jill Danford, MD
Research Sponsored by Baylor Research Institute
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Female patients of age 50 to 90 years old with OAB as defined by the International Continence Society (Urgency with or without urge incontinence, usually with frequency and nocturia in the absence of urinary tract infection or other obvious pathology) who report that symptoms cause moderate problems using the PPBC.
English-speaking and able to consent
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 29 +/-1 days
Awards & highlights
Study Summary
This study is evaluating whether a medication may help improve memory and brain function in women with overactive bladder.
Eligible Conditions
- Overactive Bladder
- Dementia
- Lower Urinary Tract Symptoms
- Urge Incontinence
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 29 +/-1 days
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~29 +/-1 days
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Diffusion tensor imaging
Functional connectivity on MRI
Resting state blood oxygenation level dependent (BOLD)changes
Secondary outcome measures
Overactive bladder questionnaire (OAB-q)
Patient Perception of Bladder Condition (PPBC)
Score on Rey Auditory Verbal Learning Test (RAVLT)
Trial Design
3Treatment groups
Active Control
Placebo Group
Group I: AnticholinergicActive Control3 Interventions
Solifenacin 5 mg tablet orally once daily for 30 days
Group II: Beta-3 agonists, adrenergicActive Control3 Interventions
Mirabegron 25 mg tablet orally once daily for 30 days
Group III: PlaceboPlacebo Group2 Interventions
Placebo pill identical will be identical to tablets in the other 2 arms.
Find a Location
Who is running the clinical trial?
Baylor Research InstituteLead Sponsor
198 Previous Clinical Trials
202,740 Total Patients Enrolled
The Methodist Hospital Research InstituteOTHER
270 Previous Clinical Trials
80,246 Total Patients Enrolled
International Urogynecological AssociationUNKNOWN
1 Previous Clinical Trials
59 Total Patients Enrolled
Frequently Asked Questions
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