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Hormone Therapy

Toviaz and Premarin Vaginal Cream for Overactive Bladder

Phase 4
Waitlist Available
Led By Eric Hurtado, MD
Research Sponsored by The Cleveland Clinic
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Postmenopausal Women defined as at least 12 months since last menstrual period
OAB symptoms for 6 months or longer with complaints of frequency (8 or more voids in a 24 hour period), and either 6 or more urgency episodes in 24 hours, and either 3 or more urge urinary incontinence episodes per 24 hours.
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 1 year
Awards & highlights

Study Summary

The use of vaginal estrogen cream in conjunction with Toviaz will be more effective than the use of Toviaz alone for the treatment of overactive bladder.

Eligible Conditions
  • Overactive Bladder

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~1 year
This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 year for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Urinary frequency as measured by a 3 day voiding diary
Secondary outcome measures
Overactive Bladder

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Toviaz and Premarin Vaginal CreamExperimental Treatment2 Interventions
Toviaz 4 mg PO q day and premarin cream 1 g per vagina 2 times a week.
Group II: Toviaz , Placebo Premarin Vaginal CreamPlacebo Group2 Interventions
Toviaz 4 mg PO q day and placebo cream 1 g per vagina 2 times a week.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Fesoterodine
FDA approved
Conjugated estrogens
FDA approved

Find a Location

Who is running the clinical trial?

The Cleveland ClinicLead Sponsor
1,019 Previous Clinical Trials
1,364,985 Total Patients Enrolled
PfizerIndustry Sponsor
4,556 Previous Clinical Trials
10,907,358 Total Patients Enrolled
Alexandriah Alas, MDStudy DirectorCleveland Clinic Florida
1 Previous Clinical Trials
176 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
~7 spots leftby Mar 2025