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Antihistamine
Treatment for Anticholinergic Syndrome
Phase 4
Waitlist Available
Led By Michelle Rainka, PharmD
Research Sponsored by Dent Neuroscience Research Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Medically-stable volunteers of either gender between 35 and 50 years old or over the age of 65
No medication changes anticipated for the duration of the study except as defined in protocol
Timeline
Screening 3 weeks
Treatment Varies
Follow Up after diphenhydramine administration (30, 60, 210, 240, 450, 480 minutes after diphenhydramine administration)
Awards & highlights
Study Summary
This trial will look at how much and for how long the brain is affected by a single dose of the drug diphenhydramine when given through an IV.
Eligible Conditions
- Anticholinergic Syndrome
- Pharmacokinetics of Diphenhydramine
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ before and after diphenhydramine administration (30, 60, 210, 240, 450, 480 minutes after diphenhydramine administration)
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~before and after diphenhydramine administration (30, 60, 210, 240, 450, 480 minutes after diphenhydramine administration)
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Change in score of battery of cognitive function tests
Secondary outcome measures
Elderly vs. adult change in score of battery of cognitive function tests after diphenhydramine
Elderly vs. adult diphenhydramine AUC
Elderly vs. adult score of battery of cognitive function tests at specified time points
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Who is running the clinical trial?
Dent Neuroscience Research CenterLead Sponsor
5 Previous Clinical Trials
111 Total Patients Enrolled
Michelle Rainka, PharmDPrincipal InvestigatorDent Neurologic Institute
Frequently Asked Questions
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