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Opioid Agonist/Antagonist
Buprenorphine/Naloxone for Postoperative Pain
Phase 4
Waitlist Available
Led By Yi Zhang, MD, PhD
Research Sponsored by Massachusetts General Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Opioid tolerance, defined as the daily use of greater than or equal to 60mg of oral morphine or an equianalgesic dose of any other opioid for more than 7 days immediately prior to the surgery
Undergoing orthopedic or general surgery
Timeline
Screening 3 weeks
Treatment Varies
Follow Up through study completion, an average of 6 days
Awards & highlights
Study Summary
This trial looks at whether buprenorphine/naloxone (bup/nx) can help manage postoperative pain in people who have developed a tolerance to opioids.
Eligible Conditions
- Postoperative Pain
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ through study completion, an average of 6 days
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~through study completion, an average of 6 days
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Length of Hospital Stay
Postoperative Opioid Consumption
Postoperative Pain Scores
Trial Design
2Treatment groups
Active Control
Group I: Buprenorphine/NaloxoneActive Control1 Intervention
Subjects will take a maximum dose of 4 mg buprenorphine and 1 mg naloxone with concurrent administration of other intravenous or oral opioids needed.
Group II: Standard Medication RegimentActive Control1 Intervention
Subjects will take conventional intravenous or oral opioid management.
Find a Location
Who is running the clinical trial?
Massachusetts General HospitalLead Sponsor
2,918 Previous Clinical Trials
13,192,775 Total Patients Enrolled
3 Trials studying Postoperative Pain
260 Patients Enrolled for Postoperative Pain
Yi Zhang, MD, PhDPrincipal InvestigatorMassachusetts General Hospital
1 Previous Clinical Trials
23 Total Patients Enrolled
Frequently Asked Questions
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