← Back to Search

Opioid Analgesic

Spinal Hydromorphone for Postoperative Pain

Phase 4
Waitlist Available
Led By Ilana Sebbag, MD
Research Sponsored by Lawson Health Research Institute
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Age > 18 years; American Society of Anesthesiologist's Physical Status (ASA-PS) < 3; Term pregnancy (> 37 weeks gestational age); Elective cesarean delivery; Spinal Anesthesia;
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 1 and 5 minutes after birth.
Awards & highlights

Study Summary

This trial will test whether hydromorphone is not worse than morphine for pain relief after childbirth.

Eligible Conditions
  • Postoperative Pain

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~1 and 5 minutes after birth.
This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 and 5 minutes after birth. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Difference in the Average Numeric Rating Score (0-10 , where 0=no pain and 10= maximum pain) during the first 24 hours.
Secondary outcome measures
Apgar Scores
Difference in NRS pain scores at specific time points in the first 24 hours.
Difference in Opioid Consumption in the first 24 hours
+5 more

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Spinal HydromorphoneExperimental Treatment1 Intervention
For the intervention group, 75 mcg of hydromorphone will be added to the spinal anesthetic mixture as a one-time injection prior to cesarean delivery.
Group II: Spinal MorphineActive Control1 Intervention
For the control group,150 mcg of preservative-free morphine will be added to the spinal anesthetic mixture as a one-time injection prior to cesarean delivery.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Hydromorphone
FDA approved

Find a Location

Who is running the clinical trial?

Lawson Health Research InstituteLead Sponsor
654 Previous Clinical Trials
413,059 Total Patients Enrolled
5 Trials studying Postoperative Pain
274 Patients Enrolled for Postoperative Pain
Ilana Sebbag, MDPrincipal InvestigatorWestern University
2 Previous Clinical Trials
205 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
~29 spots leftby Mar 2025