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Progesterone Receptor Modulator

Orally Dosed Emergency Contraception for Birth Control in Obese Women (UPA-Obesity Trial)

Phase 4
Waitlist Available
Led By ALISON EDELMAN, MD, MPH
Research Sponsored by Oregon Health and Science University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Generally healthy women
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 1 menstrual cycle, assessed up to 38 days
Awards & highlights

UPA-Obesity Trial Summary

This trial is testing whether a higher dose of emergency contraception can help it work better in obese women.

Eligible Conditions
  • Obesity
  • Birth Control

UPA-Obesity Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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Women who are in good overall health.

UPA-Obesity Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~1 menstrual cycle, assessed up to 38 days
This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 menstrual cycle, assessed up to 38 days for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Number of Participants With Delay in Follicular Rupture Beyond 5 Days
Secondary outcome measures
Maximum Serum Concentration of Ulipristal Acetate

UPA-Obesity Trial Design

3Treatment groups
Experimental Treatment
Active Control
Group I: UPA-ECx2 followed by ECx1Experimental Treatment2 Interventions
Ulipristal acetate 60mg orally x 1 dose, washout cycle, and then in next menstrual cycle 30mg orally x 1 dose. Timing of dosage depends on follicle measurements.
Group II: UPA-ECx1 Normal BMI/weightExperimental Treatment1 Intervention
Ulipristal acetate 30mg orally x 1 dose. timing of dosage depends on follicle measurements. This is to obtain a normal BMI control group.
Group III: UPA-ECx1 followed by ECx2Active Control2 Interventions
Ulipristal acetate 30mg orally x 1 dose, washout cycle and then in the next menstrual cycle, 60mg x 1 dose. Timing of dosage depends on follicle measurements.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
UPA-ECx1
2017
Completed Phase 4
~70
UPA-ECx2
2017
Completed Phase 4
~70

Find a Location

Who is running the clinical trial?

Oregon Health and Science UniversityLead Sponsor
966 Previous Clinical Trials
6,845,687 Total Patients Enrolled
29 Trials studying Obesity
9,282 Patients Enrolled for Obesity
National Institutes of Health (NIH)NIH
2,679 Previous Clinical Trials
6,910,618 Total Patients Enrolled
101 Trials studying Obesity
25,656 Patients Enrolled for Obesity
ALISON EDELMAN, MD, MPHPrincipal InvestigatorOregon Health and Science University

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is UPA-ECx1 a safe option for medical care?

"Data accumulated throughout the course of this advanced phase 4 trial gives our team at Power cause to rate UPA-ECx1's safety as a 3."

Answered by AI

What type of participants is this trial looking for?

"This clinical trial is currently recruiting 112 individuals aged 18-35 with obesity. The entry criteria necessitates that the participants are female, in good health and have a BMI of greater than 30kg/m2 (and weight at least 80kg) or less than 25 kg/m2 (and weight below 80kg). It's also imperative that they experience regular menstrual cycles every 21 to 35 days while exhibiting progesterone levels 3 ng/mL or above."

Answered by AI

Is this research endeavour open to individuals aged 25 or above?

"This research study is looking for people aged 18 to 35. Separately, there are 262 clinical trials open to minors and 767 studies available to senior citizens."

Answered by AI

Does this experiment still accept enrollees?

"From the data available on clinicaltrials.gov, this study has ended its recruitment period and is not accepting new candidates. This trial was first posted in May 2017 and last updated in September 2022; however, there are an abundance of 1201 other trials actively seeking participants at this time."

Answered by AI
~8 spots leftby Mar 2025