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Antidepressants for Depression
Study Summary
This trial will help researchers understand how different types of antidepressants affect people with depression before treatment begins.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Side effects data
From 2002 Phase 4 trial • 110 Patients • NCT00000378Trial Design
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Who is running the clinical trial?
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- You currently have a problem with using drugs or alcohol.I do not have serious heart problems as confirmed by an ECG.My vision and hearing are normal, or corrected to be normal.I often feel a lack of pleasure in activities I used to enjoy.I do not have any serious or unstable illnesses.I have tried sertraline and bupropion without improvement.I feel a lack of pleasure in activities I used to enjoy.I am receiving or have received electroconvulsive therapy for my current health condition.You are not able to stop using tobacco products for eight hours without feeling the need to use them again.I have been diagnosed with Major Depressive Disorder.I used marijuana regularly before I turned 15.I have had bad reactions or am considered unsafe to take bupropion or sertraline.I have tried at least two antidepressants without improvement.You have used recreational drugs more than the allowed amount in your lifetime.I am between 18 and 64 years old.You have thoughts of hurting yourself and the study doctor thinks it's not safe for you to continue in the study.My gender or ethnic background does not limit my participation.I am not in any treatment program except for psychotherapy.I am pregnant or might be pregnant.You have experienced more than 15 blackouts in your lifetime from drinking alcohol.I have a condition that makes it hard for me to stay still during scans.I am experiencing severe depression.I have hemophilia, poorly controlled diabetes, chronic migraines, or a history of dementia.I have had a severe head injury or concussion with significant aftereffects.You have extreme fear or anxiety that may make it hard for you to complete brain imaging tests.You are currently using drugs for fun or illegally, except for THC, as shown by a urine test.I haven't taken any blood flow or pressure medication in the last 3 weeks.You currently have an infection or are having an allergic reaction or asthma flare-up.You have been diagnosed with certain mental health conditions according to a specific manual.I have not used MAOIs in the last two weeks.I have a history of seizures.I have taken Metformin in the last 6 months.My gender or ethnic background does not limit my participation.My vision and hearing are normal, or corrected to be normal.You are right-handed.
- Group 1: MDD with BUP+ Response Marker
- Group 2: MDD with SERT+ Response Marker
- Drug Has Already Been Approved - The FDA has already approved this drug, and is just seeking more data.
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Pivotal Trial - The final step before approval, pivotal trials feature drugs that have already shown basic safety & efficacy.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Has Sertraline earned market authorization from the FDA?
"Sertraline has been approved by the appropriate authorities and is thus rated with a 3 on our scale. This signifies that it can be used in Phase 4 trials with confidence as regards safety."
What qualifications must be met for potential participants of this research?
"To meet the requirements for this medical study, prospective patients must be suffering from major depressive disorder (mdd) and aged between 18-64. The current recruitment target is 183 participants."
Does this study include octogenarians as participants?
"The age range for participants of this trial is delineated in the inclusion criteria; with a minimum age requirement of 18 and an upper limit at 64."
Are there any vacancies left to join this clinical experiment?
"This trial, which was initially posted on September 30th 2022 and last updated a month later on the 8th of September, is not actively seeking new participants. Nevertheless, there are 840 other clinical trials that still require enrolment at this moment in time."
Who else is applying?
What state do they live in?
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What portion of applicants met pre-screening criteria?
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