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Alpha-2 Adrenergic Agonist

Clonidine Pill for Anxiety (ATLAS Trial)

Phase 4
Waitlist Available
Led By Seth W Holwerda, PhD
Research Sponsored by Seth Holwerda
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 4 weeks
Awards & highlights

ATLAS Trial Summary

This trial is designed to study whether or not a short-term pharmacological blockade of sympathetic nerve activity can help ease anxiety symptoms, as well as measure the impacts on vascular function, inflammation, muscle sympathetic nerve activity, and oxidant stress.

Eligible Conditions
  • Anxiety
  • High Blood Pressure

ATLAS Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~4 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 4 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Aortic stiffness

ATLAS Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: ClonidineExperimental Treatment1 Intervention
To test the magnitude by which short-term (4 weeks) sympathetic nerve activity blockade (clonidine) improves large elastic artery stiffness, vascular inflammation and baroreflex function in subjects with moderate-to-high levels of anxiety
Group II: HydrochlorothiazideActive Control1 Intervention
Hydrochlorothiazide is a blood pressure-lowering control condition to compare to the effects of clonidine

Find a Location

Who is running the clinical trial?

Seth HolwerdaLead Sponsor
University of IowaLead Sponsor
443 Previous Clinical Trials
878,660 Total Patients Enrolled
3 Trials studying Anxiety
187 Patients Enrolled for Anxiety
Seth W Holwerda, PhDPrincipal InvestigatorUniversity of Iowa
2 Previous Clinical Trials
108 Total Patients Enrolled

Media Library

Clonidine (Alpha-2 Adrenergic Agonist) Clinical Trial Eligibility Overview. Trial Name: NCT03109795 — Phase 4
Anxiety Research Study Groups: Clonidine, Hydrochlorothiazide
Anxiety Clinical Trial 2023: Clonidine Highlights & Side Effects. Trial Name: NCT03109795 — Phase 4
Clonidine (Alpha-2 Adrenergic Agonist) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03109795 — Phase 4

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Can people who are over 20 years old participate in this trial?

"This trial is only open to adults aged 18-79. There are currently 228 clinical trials underway for patients that are younger than the age of majority and 1166 studies available for seniors."

Answered by AI

Are new enrollees still being taken in for this program?

"According to the available information, this particular trial is no longer recruiting patients. Although the last update was on May 26th, 2022, this study is not currently looking for new participants. There are 1474 other trials that might be a better fit for individuals seeking medical studies at this time."

Answered by AI

Who would be most beneficial to include in this research?

"This trial is currently seeking 30 participants that have hypertension and are aged between 18 and 79."

Answered by AI

How many volunteers will be given lenalidomide in this experiment?

"As of right now, this trial is not seeking any more participants. According to the clinicaltrials.gov website, this study was originally posted on April 10th, 2017 and was last edited on May 26th, 2022. However, if you are interested in other studies, there are presently 1442 studies actively looking for participants with hypertension and 32 trials for Clonidine Pill actively searching for participants."

Answered by AI

Is it safe to take Clonidine pills?

"Clonidine Pill has been approved, meaning it is safe."

Answered by AI

Are there any previous investigations that have used Clonidine Pill?

"At the moment, there are 32 different clinical studies being conducted for Clonidine Pill. Out of those active investigations, 12 have progressed to Phase 3 trials. Although a majority of research sites are located in Lexington, Kentucky, there are 151 total locations running trials for this medication."

Answered by AI

What are some of the conditions that Clonidine Pill is used to help treat?

"Clonidine Pill is frequently used to manage left ventricular hypertrophy. Other conditions that it can be helpful for include edema, attention deficit hyperactivity disorder (adhd), and pheochromocytomas."

Answered by AI
~4 spots leftby Mar 2025