Folic Acid for Menopause

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Cardiovascular Prevention and Rehabilitation Centre of the Montreal Heart Institute, Montréal, Canada
Menopause+2 More
Folic Acid - DietarySupplement
Eligibility
18+
All Sexes
What conditions do you have?
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Study Summary

An Evaluation of Folic Acid to Improve Endothelial Sensitivity to Shear Stress in Seniors

See full description

Eligible Conditions

  • Menopause
  • Healthy Aging
  • Aging

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

This trial is evaluating whether Folic Acid will improve 1 primary outcome and 1 secondary outcome in patients with Menopause. Measurement will happen over the course of Measured 2 hours after placebo or folic acid consumption.

Hour 2
Endothelial sensitivity to shear rate
Neurovascular transduction

Trial Safety

Safety Progress

1 of 3

Trial Design

2 Treatment Groups

Folic Acid
1 of 2
Placebo treatment
1 of 2
Experimental Treatment
Non-Treatment Group

This trial requires 40 total participants across 2 different treatment groups

This trial involves 2 different treatments. Folic Acid is the primary treatment being studied. Participants will all receive the same treatment. Some patients will receive a placebo treatment. The treatments being tested are not being studied for commercial purposes.

Folic Acid
DietarySupplement
Participant will be asked to ingest a capsule containing 5 mg of folic acid.
Placebo treatment
Other
Participant will be asked to ingest a placebo capsule.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Folic Acid
2008
Completed Phase 4
~7570

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: measured 2 hours after placebo or folic acid consumption
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly measured 2 hours after placebo or folic acid consumption for reporting.

Who is running the study

Principal Investigator
D. G.
Daniel Gagnon, Principal Investigator
Montreal Heart Institute

Closest Location

Cardiovascular Prevention and Rehabilitation Centre of the Montreal Heart Institute - Montréal, Canada

Eligibility Criteria

This trial is for patients born any sex aged 18 and older. There are 4 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
A person with a body mass index of 30 kg/m2 or lower is considered to have a healthy weight. show original
Amenorrhea for ≥ 1 year. show original
A blood pressure reading of less than 140 over 90 is considered normal. show original
Non-smoker (≥ 1-year)

Patient Q&A Section

What is menopause?

"Menopause is defined as the cessation of menses. It usually occurs after the age of 50, although it may begin earlier or later in life.\n" - Anonymous Online Contributor

Unverified Answer

What are common treatments for menopause?

"Most women receive treatment for menopause in a number of different forms of therapy. While medication for most women offers an effective treatment, some women may find that their symptoms diminish somewhat and they may therefore prefer non-invasive treatments such as herbal or natural supplements when a conventional treatment is not working." - Anonymous Online Contributor

Unverified Answer

What causes menopause?

"At the cellular level, the effects that cause menopause are the same as those responsible for osteoporosis and heart disease. However, many uncertainties persist and many more potential factors are yet to be identified." - Anonymous Online Contributor

Unverified Answer

What are the signs of menopause?

"Symptoms of women such as increased fatigue, poor concentration, weight gain, dizziness, and weakness appear before the age of 50 and often before the age of 40. Symptoms of menopause develop gradually and symptoms usually come and go as life goes on. However, menopause can also be a sudden change from a long life." - Anonymous Online Contributor

Unverified Answer

Can menopause be cured?

"Based on available scientific data and a large meta-analysis of randomized controlled intervention trials, menopause appears to be primarily a symptom of aging rather than a disease state of itself. More extensive evidence suggests that menopause is related to adverse symptoms such as osteoporosis." - Anonymous Online Contributor

Unverified Answer

Is folic acid typically used in combination with any other treatments?

"Although many of the women in this study received folic acid, there was no statistically significant difference in recurrence rates based on treatment type. The use of folic acid alone or in combination with other therapeutic options has not increased the recurrence rates of pelvic endometriosis." - Anonymous Online Contributor

Unverified Answer

Have there been any new discoveries for treating menopause?

"No newer findings that have been clinically or pharmacologically effective have been published in the last 10 years. Although the results of studies are encouraging, clinicians and researchers are not always aware of all of the latest information available." - Anonymous Online Contributor

Unverified Answer

How serious can menopause be?

"Menopause is an important and serious condition. One in three women suffer from serious emotional problems, as well as increased chance of cardiovascular disease. We are very much aware of the medical effects of our treatments and prevention tools, but it is necessary to take into account the impact for which they are used." - Anonymous Online Contributor

Unverified Answer

What is the latest research for menopause?

"Many of these studies are of low quality and fail to meet modern standards of health care. Given the risk of adverse events that can be associated with hormone replacement therapy, clinicians should be aware of how limited the evidence base is." - Anonymous Online Contributor

Unverified Answer

How does folic acid work?

"Folic acid supplementation is safe and effective in reducing menopausal symptoms in women with low or normal folate levels, including hot flashes. Folinic acid should be strongly recommended to postmenopausal women." - Anonymous Online Contributor

Unverified Answer

Does folic acid improve quality of life for those with menopause?

"Results from a recent clinical trial of the positive effects of folic acid supplementation on QOL indicate that in addition to having an effect on bone health, folic acid supplementation may also be beneficial for QOL in those experiencing menopausal symptoms." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
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