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General Anesthetic

Propofol for Anesthesia

Phase 4
Waitlist Available
Led By Simon Whyte, MBBS, FRCA
Research Sponsored by University of British Columbia
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Age ≥ 3 to ≤ 18
ASA physical status classification I-III
Timeline
Screening 3 weeks
Treatment Varies
Follow Up loss of consciousness will be expected to occur somewhere between 120-180 seconds after commencing the induction infusion.
Awards & highlights

Study Summary

This trial is studying how different doses of propofol should be given based on a person's sex and ancestry.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~loss of consciousness will be expected to occur somewhere between 120-180 seconds after commencing the induction infusion.
This trial's timeline: 3 weeks for screening, Varies for treatment, and loss of consciousness will be expected to occur somewhere between 120-180 seconds after commencing the induction infusion. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Dose of propofol required to produce apnea
Dose of propofol required to produce loss of consciousness
Secondary outcome measures
A genotyped/imputed dataset of 8 million genetic variants aggregated using SHAPEIT (v2), IMPUTE2 (v2.3.2), Phase 3 1000 Genomes Project reference panel, SNP2HLA (v1.0.2), and the Type 1 Diabetes Genetics Consortium reference panel.
Self-identified countries of family origin up to grandparents

Trial Design

1Treatment groups
Experimental Treatment
Group I: Intravenous Propofol InfusionExperimental Treatment1 Intervention
Quantification of the dose of propofol required to produce loss of consciousness and apnea.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Propofol
FDA approved

Find a Location

Who is running the clinical trial?

University of British ColumbiaLead Sponsor
1,407 Previous Clinical Trials
1,766,189 Total Patients Enrolled
BC Children's Hospital Research InstituteOTHER
12 Previous Clinical Trials
1,982 Total Patients Enrolled
Simon Whyte, MBBS, FRCAPrincipal InvestigatorBC Children's Hospital, Department of Anesthesia
2 Previous Clinical Trials
152 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Has Propofol been accepted by the FDA for medical use?

"Propofol is a safe medication, scoring a 3 on our team's 1-3 scale."

Answered by AI

Are new people being recruited for this clinical trial?

"Yes, this trial is still looking for participants. The posting date on clinicaltrials.gov was March 11th 2020, with the most recent update being October 6th 2021."

Answered by AI

What medical procedures often utilize Propofol?

"Propofol is commonly used to help patients feel sedated during a medical procedure. However, it can also be used for other conditions such as monitored anesthesia care therapy, sedative therapy, and anesthesia procedures."

Answered by AI

How many people are being given the opportunity to participate in this test phase of the treatment?

"That is correct. The website provides information that this particular study is looking for patients as the most recent update was on October 6th, 2021. It was first posted on March 11th, 2020 and is searching for 360 participants at 1 location."

Answered by AI

Is there any precedence for the use of Propofol?

"There are 80 ongoing clinical trials researching Propofol. 12 of those active studies are in Phase 3. Jinan, Shandong is where many of the studies for Propofol originate, but there are 262 locations running trials for this treatment."

Answered by AI

Would this particular test be appropriate for elderly patients?

"Children aged 3 to 18 may be eligible for this trial, as specified by the eligibility criteria. There are currently 47 other studies recruiting patients of a similar age and 169 studies are recruiting patients over the age of 65."

Answered by AI
~72 spots leftby Mar 2025