This trial is evaluating whether Larazotide Acetate will improve 2 primary outcomes and 17 secondary outcomes in patients with Syndrome. Measurement will happen over the course of 24 weeks.
This trial requires 20 total participants across 2 different treatment groups
This trial involves 2 different treatments. Larazotide Acetate is the primary treatment being studied. Participants will all receive the same treatment. Some patients will receive a placebo treatment. The treatments being tested are in Phase 2 and have already been tested with other people.
"Results from a recent clinical trial indicate that a syndrome of chronic illness with cognitive change and neurological and cardiovascular abnormalities may be a curable syndrome." - Anonymous Online Contributor
"A patient with multiple signs of disease may have a number of conditions responsible for the signs.\n\nThere may be many causes of pain. It may result from a specific medical condition, such as cancer, from inflammation or inflammation-related conditions like rheumatoid arthritis or gout or from musculoskeletal disorders such as osteoarthritis. A symptom which may be related to a specific condition is not always present.\n\nOften there will be no specific treatment for a condition that causes pain, and the pain will need to be addressed." - Anonymous Online Contributor
"Syndromes may be defined as a group of disorders with common symptoms (e.g. fever, vomiting, and weakness), or can be defined as a constellation of signs and symptoms. Examples include Behçets’ disease, essential tremor, essential thrombocythemia, lymphoma, multiple system atrophy, paroxysmal nocturnal hemoglobinuria, and psoriasis. A syndrome also may be defined as a characteristic biological abnormality that is usually seen in a group of individuals with other similar symptoms that are not due to an identifiable disease, disorder, or syndromes.\n\nThis chapter provides an exhaustive classification of syndrome types according to body system (e.g." - Anonymous Online Contributor
"The incidence of the syndrome is low in this cohort of adults. However a larger study is needed to establish these findings in a different population." - Anonymous Online Contributor
"Results from a recent clinical trial on the association between childhood trauma and the symptoms of adulthood somatoform disorders suggest the potential use of psychiatric diagnoses in unraveling the neural bases of this syndrome." - Anonymous Online Contributor
"Many syndromes are treated through pharmacological and/or psychological therapies alone. Some types of syndromes such as the anxiety spectrum, are often treated through CBT. The most common medications for syndromes are antidepressants which are often prescribed as an adjunct to CBT. A large number of medications are used to treat syndromes such as the panic spectrum and anxiety spectrum but are not common for all syndromes. A small number of medications are used as a mainstay for syndromes although are not very common and are mainly used for severe and/or persistent cases of these syndromes. One exception is the use of benzodiazepines for the management of insomnia." - Anonymous Online Contributor
"Syndromes can be divided into two groups: syndromes caused by mutations in genes and syndromes caused by environmental exposures. While some conditions occur frequently in humans, it would be difficult for treatment strategies to be tailored to specific syndromes. Thus, it is essential for scientists to continue searching for new ways to treat syndromes, hoping to one day find a cure." - Anonymous Online Contributor
"Syndromes are more relevant than tumors alone as a reason for enrolling in clinical trials. A number of important clinical trials have been designed to select patients with rare conditions for new drugs or investigational agents." - Anonymous Online Contributor
"Larazotide acetate is used to treat patients with Neuroendocrine tumors and cancer. This suggests a broader clinical use for this drug. Please go to [Medscape(https://emedicine.medscape.com/articles/viewarticle/106638) to review further research." - Anonymous Online Contributor
"Larazotide acetate is used to treat adult and childhood-onset intractable central neuropathic pain. It can also reduce chronic dyspnea and, in pediatric ALS, it can affect spasticity and fatigue. Treatment with larazotide acetate can improve symptoms of ALS." - Anonymous Online Contributor
"A patient with the syndrome can be anywhere in their 30s as a result of a delay in diagnosis. This is not only a cosmetic issue for patients and clinicians but also a huge loss of professional productivity from physicians and other healthcare professionals as they are forced to revisit patients unnecessarily. As physicians become increasingly busy treating other patient needs and have less time to consider new cases of suspected syndrome, this issue of overwork must be kept in check through timely recognition and reporting of syndrome cases." - Anonymous Online Contributor
"LA used in combination with other treatments did not significantly reduce the TFI in the entire treatment arm over placebo. However, there were significant differences in tumor response between the placebo arm and the LA plus radiotherapy arm." - Anonymous Online Contributor