Dexamethasone for Stomatitis

In a recent study, findings demonstrated that topical azithromycin gel applied twice a day for 4 weeks could effectively cure stomatitis in half of patients. Side effects were not observed.

Stomatitis is a chronic viral disease caused by infection with one or more herpesviruses, although it can also be a reaction to a bacterial infection with Streptococcus faecalis.\n

Stomatitis is a disease that can be divided into three types: fungal, viral, and bacterial induced. The cause of each stomatitis is different but needs to be treated for this disease to be eliminated.

There is significant morbidity and medical costs associated with stomatitis, and it is imperative that our society take a proactive approach in identification, medical management, and prevention to reduce the burden of this condition and its associated morbidity and mortality.

The majority of patients with stomatitis are treated with topical products, such as azelaic acid, anti-inflammatories, corticosteroids and topical antibiotics. However many of the therapies used for stomatitis are not proven to be of little value and are not in common use. It is a huge issue for the patient not to be misdiagnosed with stomatitis due to the long term pain that stomatitis will cause to an individual and their family and social life. It is clear that there is very limited knowledge within research in the field and that there needs to be more education for those affected. More research needs to be carried out in research centres.

Pain, redness and swelling of the mouth are suggestive of periodontal disease and may be accompanied by teeth that feel tight and have bad breath. The presence of inflammation in the mouth is probably due to a dental or chronic gum infection. Regular dental visits are essential in preventing and relieving signs and symptoms of stomatitis.

In addition to the established safe profile of dexamethasone for moderate or less severe disease, we found that dexamethasone was a safe option used for mild to moderate disease, and it was more effective on reducing fever and pain and decreasing inflammation as well as promoting healing than other pain medicines evaluated.

There were no significant differences found between 1st year and 2nd year students regarding reliability. While there was a significant difference found between the different academic year students, it seems that there was a decrease in the reliability value per year. In summary, this study shows that there was not any significant difference found between the different academic year students concerning reliability, which tells that the research is not always changing per academic year.

This pedigree of a typical stomatitis family, as seen on clinical photographs and the family pedigree, strongly supports both autosomal recessive inheritance and a novel mutation in a locus for stomatitis. The discovery of a rare mutation in a gene for stomatitis supports the concept that stomatitis may be a genetically heterogeneous condition, with several new mutations in unidentified genes.

Stomatitis is classified as either minor (mild inflammatory infiltrates, usually seen in the submucosa) or major (seen in the submucosa and/or muscularis propria). The former are often self-limiting, while the latter are more severe and may be life-threatening. There is currently no way of predicting which of the two the patient will suffer. The differential diagnosis should include the entire head and neck region as well as all other areas in the body. Other forms of stomatitis include atrophic glossitis, lichen sclerosus, lichen planus, and oral candidiasis.

All of these clinical trials involved oral dexamethasone. Only two of them involved topical application. In each of these cases the use of topical dexamethasone seems to be less effective than the oral form. It is uncertain whether these studies showed that topical dexamethasone has an equivalent effect to oral dexamethasone to treat sore throat, or whether topical treatment is equivalent to oral treatment.