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Electrolyte Supplement

Magnesium sulfate for Esophageal Disorders (MgPOEM Trial)

Phase 2
Waitlist Available
Led By Richard K Kim, MD
Research Sponsored by Stanford University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
- Planned peroral endoscopic myotomy procedure
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up from 24 hours after extubation to 48 hours after extubation
Awards & highlights

MgPOEM Trial Summary

This trial found that magnesium may help reduce postoperative pain and the amount of opioids needed after surgery for peroral endoscopic myotomy.

Eligible Conditions
  • Spastic Esophageal Disorders

MgPOEM Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
You have a planned surgery called peroral endoscopic myotomy.

MgPOEM Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~from 24 hours after extubation to 48 hours after extubation
This trial's timeline: 3 weeks for screening, Varies for treatment, and from 24 hours after extubation to 48 hours after extubation for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Secondary outcome measures
Average Visual Acuity Score Pain Score in postanesthesia care unit
Esophageal Symptoms Questionnaire Score (ESQ)
Postoperative day 1 opioid consumption
+1 more

MgPOEM Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Magnesium sulfate 50 mg/kg bolus + 25 mg/kg/hr infusionExperimental Treatment1 Intervention
Bolus to be administered at start of mucosal incision, followed by infusion. Infusion to be terminated at extubation.
Group II: Normal saline 0.9% 50 mg/kg bolus + 25 mg/kg/hr infusionPlacebo Group1 Intervention
Bolus to be administered at start of mucosal incision, followed by infusion. Infusion to be terminated at extubation.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Magnesium sulfate
2018
Completed Phase 4
~1630

Find a Location

Who is running the clinical trial?

Stanford UniversityLead Sponsor
2,374 Previous Clinical Trials
17,332,835 Total Patients Enrolled
Richard K Kim, MDPrincipal InvestigatorStanford University
1 Previous Clinical Trials
30 Total Patients Enrolled
Joo H Hwang, MD PhDPrincipal InvestigatorStanford University

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

In what situations is Magnesium sulfate usually administered?

"Magnesium sulfate is the gold standard for treating hypomagnesemia, but it has also been successful in combating poisoning, prophylaxis of hypomagnesemia, and contusions."

Answered by AI

Are there any remaining vacancies for participants in this clinical research?

"As per clinicaltrials.gov, this medical trial is currently enrolling patients and has been active since December 28th 2020 with the most recent edit being made on June 10th 2021."

Answered by AI

Is Magnesium sulfate an innocuous substance for humans?

"Magnesium sulfate is rated a 2 on the scale of 1 to 3. This score indicates that while there are some data collected in regard to its safety, no clinical studies have been completed yet to attest efficacy."

Answered by AI

Is there any extant research that utilizes Magnesium sulfate?

"Presently, 27 experiments are investigating the therapeutic potential of Magnesium sulfate. Out of those trials, 8 have advanced to Phase 3. The majority are located in Guangzhou and other parts of Guangdong, totaling 42 locations altogether."

Answered by AI

How many people have been invited to partake in this experiment?

"Affirmative. According to the details hosted on clinicaltrials.gov, this medical experiment began recruiting patients in December of 2020 and is still actively doing so today as per its last update on June 10th 2022; they are looking for 100 participants at 1 site."

Answered by AI
~22 spots leftby Mar 2025