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Combination Therapy for Bone Cancer
Study Summary
This trial is comparing two treatments for a type of bone cancer. One treatment is just radiation therapy, and the other is radiation therapy with drugs that may help kill cancer cells or reduce bone pain. It is not yet known which treatment is more effective.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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- My heart is functioning well.I haven't needed antibiotics for an infection in the last 14 days.I have a severe illness that is not related to my cancer.I will use a latex condom during sex if my partner can have children.I am not taking more than 10 mg of prednisone or its equivalent daily.I have not used proteasome inhibitors or IMiDs before.I have a GI condition or had a procedure that may affect drug absorption.My radiation therapy dose was between 4500 and 6000 cGy.I have had a condition where my lymphocytes grow abnormally.I am 18 years old or older.I can take care of myself and am up and about more than half of the day.I have not had heart failure in the last 6 months.I haven't taken specific strong drugs that affect drug metabolism in the last 14 days.My disease can be measured through blood or urine tests.I haven't received any treatment after radiation therapy.My cancer is confirmed as a single bone marrow tumor.I haven't had cancer in the last 5 years, except for skin cancer.I haven't had major surgery in the last 3 weeks.My nerve damage symptoms are mild to moderate.I have been cancer-free for at least 5 years.I have a history of cancer.I have had diarrhea in the last 2 weeks.I haven't had chest pain or a heart attack in the last 6 months.I developed red, painful lumps on my skin after starting a new medication.I have had a dental check-up in the last 35 days.I am not pregnant and use effective birth control.
- Group 1: ixazomib + lenalidomide + dexamethasone + zoledronic acid
- Group 2: zoledronic acid
- Pivotal Trial - The final step before approval, pivotal trials feature drugs that have already shown basic safety & efficacy.
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- All Individual Drugs Already Approved - Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
- Approved for 60 Other Conditions - This treatment demonstrated efficacy for 60 other conditions.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
What other zoledronic acid research exists?
"zoledronic acid was first studied in 2002 by the Manitoba Blood & Marrow Transplant Program CancerCare Manitoba. There have been a total of 1517 completed clinical trials to date. As of now, there are 784 live clinical trials, with many of these studies based in Princeton, Illinois."
For what reasons is zoledronic acid commonly given to patients?
"Zoledronic acid can be used to effectively treat ophthalmia, sympathetic, and at least two prior systemic chemotherapy regimens, as well as branch retinal vein occlusion."
Is zoledronic acid use associated with any health risks?
"Zoledronic acid has received a score of 3 from our team at Power. This is because it has progressed to Phase 3 clinical trials, which demonstrates some efficacy and multiple rounds of data supporting safety."
If a patient meets the qualifications, can they still join the clinical trial?
"This study is not recruiting at the moment, but this may change in the future. According to the latest update on 8/16/2021, this trial was first posted on 12/1/2015. If you're interested in other studies, 40 trials for plasmacytoma and 784 for zoledronic acid are currently looking for participants."
How many human participants are currently enrolled in this clinical trial?
"No, this particular clinical trial is not actively enrolling. The study was initially posted on December 1st, 2015 but was last edited on August 16th, 2021. If you are looking for other studies, 40 trials for plasmacytoma and 784 trials for zoledronic acid are still enrolling patients."
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