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Antibiotic

Doxycycline for Pancreatic Cancer

Phase 2
Waitlist Available
Led By Susan Tsai, MD, MHS
Research Sponsored by Medical College of Wisconsin
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Patients who will receive neoadjuvant therapy (chemoradiation) are eligible.
Histologically or cytologically confirmed pancreatic adenocarcinoma which may be acquired using a fine needle aspiration.
Timeline
Screening 3 weeks
Treatment Varies
Follow Up month 3 visit
Awards & highlights

Study Summary

This study is evaluating whether doxycycline can reduce the number of cancer stem cells in people with pancreatic cancer.

Eligible Conditions
  • Pancreatic Cancer

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~month 3 visit
This trial's timeline: 3 weeks for screening, Varies for treatment, and month 3 visit for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Determine the Efficacy of Doxycycline in Inducing Metakaryotic Cell Death in Primary Pancreatic Tumors as Measured by Pathologic Response

Side effects data

From 2021 Phase 4 trial • 26 Patients • NCT04167085
4%
Sinus infection
4%
Foot infection
4%
Metastatic lung cancer dx
4%
Blurred vision
4%
Emesis
4%
Pneumonia
100%
80%
60%
40%
20%
0%
Study treatment Arm
Doxycycline
Placebo

Trial Design

1Treatment groups
Experimental Treatment
Group I: Doxycycline Administered to PatientsExperimental Treatment1 Intervention
Patients will receive oral doxycycline and trough serum concentrations for pharmacokinetic studies will be obtained.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Doxycycline
FDA approved

Find a Location

Who is running the clinical trial?

Medical College of WisconsinLead Sponsor
604 Previous Clinical Trials
1,162,244 Total Patients Enrolled
Susan Tsai, MD, MHSPrincipal InvestigatorMedical College of Wisconsin
1 Previous Clinical Trials
125 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
~2 spots leftby Mar 2025