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Ropivacaine Continuous Infusion for Osteoarthritis

Phase 3
Waitlist Available
Led By Benjamin Wilke, MD
Research Sponsored by Mayo Clinic
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Has an underlying diagnosis of osteoarthritis indicated for a total knee arthroplasty.
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 60 days, or until discontinuation of narcotic medication (whichever is later)
Awards & highlights

Study Summary

This trial will study how well a pain-relieving catheter works for people who have had knee-replacement surgery. The catheter will give either a large dose of medication all at once or a small continuous infusion of pain medicine.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
You have been diagnosed with osteoarthritis and need a total knee replacement surgery.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~60 days, or until discontinuation of narcotic medication (whichever is later)
This trial's timeline: 3 weeks for screening, Varies for treatment, and 60 days, or until discontinuation of narcotic medication (whichever is later) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Post-operative Pain Levels
Secondary outcome measures
Amount of Medication Administered
Duration of Narcotic Used

Side effects data

From 2023 Phase 3 trial • 60 Patients • NCT05053087
10%
Catheter removed early
5%
Knee bruising
5%
Knew swelling
100%
80%
60%
40%
20%
0%
Study treatment Arm
Ropivacaine Continuous
Single Shot Adductor Canal
Ropivacaine Intermittent Bolus

Trial Design

3Treatment groups
Experimental Treatment
Placebo Group
Group I: Ropivacaine intermittent bolusExperimental Treatment1 Intervention
Subjects will have a catheter placed in the Post Anesthesia Care Unit following clinically indicated surgery with 0.2% ropivacaine dispersed in pulsed intermittent bolus.
Group II: Ropivacaine continuousExperimental Treatment1 Intervention
Subjects will have a catheter placed in the Post Anesthesia Care Unit following clinically indicated surgery with 0.2% ropivacaine dispersed in a continuous infusion.
Group III: Single shot adductor canalPlacebo Group1 Intervention
Subjects will have a catheter placed in the Post Anesthesia Care Unit following clinically indicated surgery with saline.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Ropivacaine Intermittent Bolus
2022
Completed Phase 3
~60
Ropivacaine Continuous Infusion
2022
Completed Phase 3
~60

Find a Location

Who is running the clinical trial?

Mayo ClinicLead Sponsor
3,176 Previous Clinical Trials
3,757,991 Total Patients Enrolled
28 Trials studying Osteoarthritis
2,830 Patients Enrolled for Osteoarthritis
Benjamin Wilke, MDPrincipal InvestigatorMayo Clinic
2 Previous Clinical Trials
145 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there precedents for using Ropivacaine Continuous Infusion in medical research?

"73 clinical trials are underway to study Ropivacaine Continuous Infusion, 16 of which are in the final Phase 3. Most of the trials are based in Karachi, Sindh, but there are 93 locations running trials for this treatment in total."

Answered by AI

What conditions does Ropivacaine Continuous Infusion help alleviate?

"Ropivacaine Continuous Infusion is most typically used to numb patients during surgery. However, it has other medical applications, such as reducing pain during and after childbirth and mitigating post-operative pain."

Answered by AI

Does this experiment only include individuals who are 50 or younger?

"The age range for patients that are eligible for this trial are between 18-89 years old. In contrast, there are 39 clinical trials for patients that are under 18 and 508 for patients 65 and older."

Answered by AI

Is this research study actively looking for more participants?

"From the information available on clinicaltrials.gov, it appears that this trial is still actively looking for participants. The trial was originally posted on April 13th, 2022 and the most recent edit was on April 28th, 2022."

Answered by AI

Has Ropivacaine Continuous Infusion been cleared by the FDA?

"There is some clinical data affirming Ropivacaine Continuous Infusion's efficacy, and multiple rounds of safety data, which gives it a score of 3."

Answered by AI

Might I be eligible to help researchers by enrolling in this clinical trial?

"Sixty individuals suffering from osteoarthritis will be recruited for this clinical trial, with patients' ages ranging from 18 to 89 years old. To be eligible, patients must meet the following requirements: They must be between 18 and 90 years old, willing to comply with the study's procedures, and have a diagnosis of osteoarthritis that would indicate the need for a total knee arthroplasty."

Answered by AI

Who else is applying?

What state do they live in?
Louisiana
How old are they?
65+
What site did they apply to?
Mayo Clinic in Florida
What portion of applicants met pre-screening criteria?
Met criteria

How responsive is this trial?

Typically responds via
Email
~21 spots leftby Mar 2025