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Hormone Therapy

Oxytocin for Pain Relief

Phase 2
Waitlist Available
Led By James C Eisenach, MD
Research Sponsored by Wake Forest University Health Sciences
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Body Mass Index (BMI) <40
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 114 minutes after baseline
Awards & highlights

Study Summary

This trial is to study the effects of oxytocin on pain relief.

Who is the study for?
This trial is for men and women aged 18-75 with a BMI under 40. Women of childbearing age must use effective birth control. Participants should be in good health or, if they have knee arthritis, have controlled blood pressure. People can't join if they're pregnant, nursing, recently pregnant, have certain chronic conditions like neuropathy or diabetes, take daily pain medications, or are allergic to Pitocin ingredients.Check my eligibility
What is being tested?
The study tests how oxytocin given by IV affects pain relief at the site of injection in healthy volunteers and those with severe knee arthritis. The drug's effects on skin perception will be measured using a heated probe while participants rate their pain on a scale from 0 to 10.See study design
What are the potential side effects?
While not explicitly stated in the provided information, potential side effects may include reactions at the infusion site such as redness or swelling; changes in heart rate; nausea; headache; emotional changes due to oxytocin's known effects on mood and social bonding.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
Your body mass index (BMI) is less than 40.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~114 minutes after baseline
This trial's timeline: 3 weeks for screening, Varies for treatment, and 114 minutes after baseline for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Verbal pain after heating the skin to 45 degrees Celsius

Trial Design

1Treatment groups
Experimental Treatment
Group I: OxytocinExperimental Treatment1 Intervention
Oxytocin will be administered at increasing and decreasing rates
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Oxytocin
2016
Completed Phase 4
~2340

Find a Location

Who is running the clinical trial?

Wake Forest University Health SciencesLead Sponsor
1,233 Previous Clinical Trials
1,001,936 Total Patients Enrolled
8 Trials studying Osteoarthritis
684 Patients Enrolled for Osteoarthritis
James C Eisenach, MDPrincipal InvestigatorWake Forest University Health Sciences
17 Previous Clinical Trials
809 Total Patients Enrolled
1 Trials studying Osteoarthritis
80 Patients Enrolled for Osteoarthritis

Media Library

Oxytocin (Hormone Therapy) Clinical Trial Eligibility Overview. Trial Name: NCT04435704 — Phase 2
Osteoarthritis Research Study Groups: Oxytocin
Osteoarthritis Clinical Trial 2023: Oxytocin Highlights & Side Effects. Trial Name: NCT04435704 — Phase 2
Oxytocin (Hormone Therapy) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04435704 — Phase 2

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What potential risks must be taken into consideration when utilizing Oxytocin to treat patients?

"Despite the lack of efficacy data, there is sufficient evidence to support Oxytocin's safety - thus receiving a score of 2."

Answered by AI

What is the scope of enrollment for this research-based endeavor?

"Unfortunately, this trial has recently closed recruitment. It was initially published on June 1st 2022 and last modified on May 27th 2021. If you're searching for other studies, 452 trials are presently enrolling patients with osteoarthritis of the knee while 53 separate clinicals seek participants to test Oxytocin's efficacy."

Answered by AI

Is there an opportunity for new participants to join this clinical experiment?

"Evidenced on clinicaltrials.gov, this research is no longer actively seeking participants since its last update on May 27th 2021. Despite that fact, there are currently 505 other trials recruiting patients."

Answered by AI

Would I be eligible to participate in this experiment?

"Aspiring members of this clinical trial must have osteoarthritis in the knee, be aged between 18 and 75 years old, and may join a cohort of up to 26 participants."

Answered by AI

Are those aged 45 or above eligible to participant in this research?

"This trial stipulates that potential enrollees must be between 18 and 75 years of age to meet the eligibility criteria."

Answered by AI

What medical indications does Oxytocin typically address?

"Oxytocin is a commonly used treatment for labour, uterine contractions and post-birth bleeding."

Answered by AI

Who else is applying?

What state do they live in?
Connecticut
How old are they?
65+
What site did they apply to?
Wake Forest Baptist Health
What portion of applicants met pre-screening criteria?
Met criteria
~9 spots leftby Mar 2025