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Anti-viral

4 for Postherpetic Neuralgia

Phase 2
Waitlist Available
Research Sponsored by aRigen Pharmaceuticals, Inc.
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
at least 18 years of age
diagnosed with herpes zoster
Timeline
Screening 3 weeks
Treatment Varies
Follow Up day 8
Awards & highlights

Study Summary

A multi-center, randomized, 4-arm, placebo-controlled, double-blind efficacy study of ARYS-01 (sorivudine) cream 3%.

Eligible Conditions
  • Postherpetic Neuralgia
  • Shingles

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~day 8
This trial's timeline: 3 weeks for screening, Varies for treatment, and day 8 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
The effect of ARYS-01 (sorivudine) cream (with or without Valaciclovir) on the reduction of the crusting stage of VZV rash present at Day 8.
Secondary outcome measures
The time to cessation of new lesion formation, and time to cessation of Zoster-associated pains, pain intensity, rash healing and size reduction, and lesion dissemination.

Trial Design

4Treatment groups
Experimental Treatment
Active Control
Placebo Group
Group I: 4Experimental Treatment2 Interventions
Active cream BID for 10 days and active valaciclovir caplets TID from days 1-10
Group II: 3Experimental Treatment3 Interventions
Active cream BID for 10 days and placebo valaciclovir caplets TID from days 1-3 and active valaciclovir caplets 1 gram TID from days 4-10
Group III: 2Active Control3 Interventions
Placebo cream BID for 10 days and active valaciclovir caplets TID from days 1-10
Group IV: 1Placebo Group2 Interventions
Placebo cream BID for 10 days and placebo valaciclovir caplets TID from days 1-3 and active valaciclovir caplets 1 gram TID from days 4-10
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
placebo
2010
Completed Phase 4
~6580
Valaciclovir
FDA approved

Find a Location

Who is running the clinical trial?

aRigen Pharmaceuticals, Inc.Lead Sponsor

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
~18 spots leftby Mar 2025