CLINICAL TRIAL

Ixazomib for Multiple Myeloma

Waitlist Available · 18+ · All Sexes · Pawtucket, RI

This study is evaluating whether a new drug called ixazomib is more effective than bortezomib.

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About the trial for Multiple Myeloma

Eligible Conditions
Neoplasms, Plasma Cell · Multiple Myeloma

Treatment Groups

This trial involves 2 different treatments. Ixazomib is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase 2 and have already been tested with other people.

Main TreatmentA portion of participants receive this new treatment to see if it outperforms the control.
Dexamethasone
DRUG
Cyclophosphamide
DRUG
Ixazomib
DRUG
Control TreatmentAnother portion of participants receive the standard treatment to act as a baseline.

About The Treatment

Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Dexamethasone
FDA approved
Cyclophosphamide
FDA approved
Ixazomib
FDA approved

Eligibility

This trial is for patients born any sex aged 18 and older. There are 10 eligibility criteria to participate in this trial as listed below.

Inclusion & Exclusion Checklist
Mark “yes” if the following statements are true for you:
Any person who is expected to live for at least six months must have their condition confirmed by a treating investigator. show original
Age ≥ 18 years of age
In order to participate in this study, patients must have a diagnosis of multiple myeloma that has not been previously treated show original
The ECOG performance status is 0-1. show original
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Odds of Eligibility
Unknown<50%
Be sure to apply to 2-3 other trials, as you have a low likelihood of qualifying for this one.Apply To This Trial
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Approximate Timelines

Please note that timelines for treatment and screening will vary by patient
Screening: ~3 weeks
Treatment: varies
Reporting: Through study treatment completion, an average of 2 years
This trial has approximate timelines as follows: 3 weeks for initial screening, variable treatment timelines, and reporting: Through study treatment completion, an average of 2 years.
View detailed reporting requirements
Trial Expert
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- What options you have available- The pros & cons of this trial
- Whether you're likely to qualify- What the enrollment process looks like

Measurement Requirements

This trial is evaluating whether Ixazomib will improve 1 primary outcome and 1 secondary outcome in patients with Multiple Myeloma. Measurement will happen over the course of Assessed at baseline and end of study, up to 2 years, end of study reported.

Evaluation of the Toxicities Associated With Ixazomib With Metronomic Cyclophosphamide and Dexamethasone.
ASSESSED AT BASELINE AND END OF STUDY, UP TO 2 YEARS, END OF STUDY REPORTED
Evaluation of the Response Rate of Ixazomib With Metronomic Cyclophosphamide and Dexamethasone for First-line Treatment of Multiple Myeloma.
THROUGH STUDY TREATMENT COMPLETION, AN AVERAGE OF 2 YEARS

Patient Q & A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Can multiple myeloma be cured?

The response rate to bortezomib of 50% or more was found to be a good indicator for prolonged remission at one year. This rate is comparable to many previously published results of the European Commission-approved dose schedules. Bortezomib should be considered as a therapeutic option in patients with multiple myeloma, even in the most critical settings as long as treatment results are carefully monitored.

Anonymous Patient Answer

What are common treatments for multiple myeloma?

The most common treatments for multiple myeloma are proteasome inhibitor treatment plus dexamethasone for induction, thalidomide, and bortezomib for consolidation, and autologous stem cell transplantation . In addition, if you want to join a new clinical trial, you can search recent trials by treatment, condition, or location.

Anonymous Patient Answer

What are the signs of multiple myeloma?

Hypercalcaemia, anorexia and abdominal pain are common. Increased kidney function can occur early on and can indicate the presence, and later stage, of multiple myeloma. The degree of renal impairment can predict the time of death.\n

Anonymous Patient Answer

What is multiple myeloma?

Multiple myeloma affects males more often than females. In our area, nearly all patients are over the age of 70 before diagnosis and patients diagnosed before age 40 have a survival comparable with patients diagnosed later. Survival from multiple myeloma remains short and depends on the disease-free interval, number of courses of therapy, age, and comorbidities at diagnosis.

Anonymous Patient Answer

What causes multiple myeloma?

The causes of multiple myeloma are complex, and vary between the American and European populations. The association between multiple myeloma and infection appears to differ between American and European populations. In the U.S. we have found a clear association while in Europe the data are not as clear-cut.

Anonymous Patient Answer

How many people get multiple myeloma a year in the United States?

The National MM Registry of the US National Cancer Institute (USNCI) estimates over 19,000 multiple myeloma patients will be diagnosed in the United States in 2020. The number who are currently diagnosed with multiple myeloma is approximately 10,000 (range 6,000 to 12,000). This number is expected to increase by 3,500 cases over the next 10 years.

Anonymous Patient Answer

What is the latest research for multiple myeloma?

There is a limited number of studies and studies are of varying quality. The majority of the trials were single center, of low quality and have results that cannot be generalized. There are no adequately powered prospective randomized controlled trials. Trials should include more patients, study larger geographical areas, and examine the effect of sequential therapies that are known to be effective in relapsed and refractory disease.

Anonymous Patient Answer

How quickly does multiple myeloma spread?

The median survival in the United States declined by 11% between 2003 and 2004, but more than half of these deaths occurred in people under 60. The percentage of people with multiple myeloma living 10 years or longer almost doubled between 2001 and 2003, which suggests that multiple myeloma is slowly gaining on-stage survivors.

Anonymous Patient Answer

How serious can multiple myeloma be?

Survival following treatment with ASCT is longer for all stages of myeloma, although mortality rates still exist. In particular, ASCT has prolonged life and may improve outcomes in patients with myeloma at stage 3 or 4 with ISS or in those older than 80 years with no ISS.

Anonymous Patient Answer

Is ixazomib typically used in combination with any other treatments?

Ixazomib is used as a single agent or in combination with a number of treatments in the treatment of multiple myeloma and in combination with a number of agents in other solid tumors, even in patients with CNS involvement and with bortezomib-refractory disease.

Anonymous Patient Answer

Who should consider clinical trials for multiple myeloma?

[A large fraction of patients are eligible for MMM with an acceptable complication rate and low treatment delay to follow-up visits. However, the vast majority of trials in MMM have poor power and are likely to reach type II error or even fail to achieve type I error because of inclusion criteria; therefore, patients should probably not be excluded unnecessarily unless there are other concerns.]{Read more about this decision-making process at http://www.withpower.

Anonymous Patient Answer

What is the primary cause of multiple myeloma?

Genetic predisposition, environmental factors or a combination of both may account for the onset of MM in individual patients. These factors differ from patient to patient indicating different pathogeneses.

Anonymous Patient Answer
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