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COX-2 PET Imaging for Multiple Sclerosis
Study Summary
This trial is exploring if cyclooxygenase-2 (COX-2), an enzyme found in the brain during inflammation, is detectable in the brains of people with MS.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
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- You had an MRI scan more than 180 days before or after the PET scan.People with HIV infection cannot participate because we want to focus on how MS affects neuroinflammation without the influence of HIV.You have other serious brain or medical conditions that may affect your thinking ability.You are 18 years old or older.You have a medical condition that makes it unsafe for you to have the procedures done in the study, or you have a severe medical or psychiatric illness other than MS. You also have specific allergies or history of bleeding that make it unsafe for you to take Celecoxib or ketoprofen.You have taken certain medications like NSAIDs, aspirin, corticosteroids, or immunosuppressants within a specific time before the PET scan.You have HIV.You have abnormal results on tests for heart function, blood counts, kidney and liver function, and mineral levels.You cannot lie flat and still for at least two hours on the scanner bed. This includes being claustrophobic, too overweight for the scanner, or having uncontrollable behavioral symptoms.
- Group 1: One arm
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Is it possible for me to join this medical trial?
"This clinical trial is recruiting 16 participants with multiple sclerosis aged 18-99. The key requirements are as follows: applicants must have been enrolled in UMB protocol HP-00079860, be of either gender, and demonstrate good health via physical examination and medical history. Additionally, female candidates should employ medically acceptable contraception methods."
Does this research program accept participants aged below 75 years old?
"This study is enlisting adults aged between 18 and 99."
Is the research team currently recruiting participants for this experiment?
"Clinicaltrials.gov reports that this clinical trial is currently looking for participants, with the first posting taking place on June 7th 2022 and an update made as recently as September 21st 2022."
To what extent is this treatment hazardous to individuals?
"Due to the experimental nature of this treatment, and its status as a Phase 2 trial with some data supporting safety but none affirming efficacy, our team at Power gave it an assessment score of 2."
What is the maximum capacity for enrollment into this experiment?
"Affirmative. Online records on clinicaltrials.gov suggest that this medical trial is still actively recruiting participants, having been initially posted on June 7th 2022 and most recently edited a month ago on September 21st 2022. The study demands 16 volunteers to be found at one location."
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