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Aerobic Exercise Training (AET) for Interstitial Lung Disease

N/A
Waitlist Available
Led By Leighton Chan, M.D.
Research Sponsored by National Institutes of Health Clinical Center (CC)
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Physically inactive (no participation in a structured exercise program as defined as more than 30 minutes of exercise 3 or more days a week within the last 6 months).
No episodes of fainting or significant chest pain for at least one month.
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, after 10 weeks, after 20 weeks (for crossover group)
Awards & highlights

Study Summary

This trial is to test if aerobic exercise is safe and helpful for patients with interstitial lung disease, a disease where the lungs can't take in enough oxygen. In an uncontrolled study, we saw that patients who did aerobic exercise had better cardiorespiratory function, could do more physical work, and had a better quality of life. So far, aerobic exercise seems safe and plausible for helping patients with ILD.

Eligible Conditions
  • Interstitial Lung Disease
  • Interstitial Pneumonitis
  • Idiopathic Pulmonary Fibrosis
  • Desquamative Interstitial Pneumonia

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
You have not participated in a regular exercise program for at least 6 months, which means you have not been exercising for at least 30 minutes, 3 or more days a week.
Select...
You haven't had any fainting or severe chest pain in the last month.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~before and after 10 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and before and after 10 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in 6-minute Walk Test Distance (6MWD)
Secondary outcome measures
Patient-reported outcomes
Treadmill cardiorespiratory exercise test (CPET)

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Aerobic Exercise Intervention (AET+)Experimental Treatment2 Interventions
Participant with interstitial lung disease performed aerobic exercise three times a week plus weekly education for 10 weeks
Group II: Control Group (CON)Active Control1 Intervention
Participant with interstitial lung disease performed weekly education for 10 weeks, then crossed over to perform aerobic exercise three times a week for 10 weeks

Find a Location

Who is running the clinical trial?

George Mason UniversityOTHER
58 Previous Clinical Trials
48,748 Total Patients Enrolled
Inova Fairfax HospitalOTHER
10 Previous Clinical Trials
7,633 Total Patients Enrolled
National Institutes of Health Clinical Center (CC)Lead Sponsor
383 Previous Clinical Trials
988,945 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is this study meant for young adults or can elderly patients participate?

"The minimum age requirement for this clinical trial is 21 years old. The maximum age an individual can be and still participate in the study is 80 years old."

Answered by AI

Are patients being accepted into this clinical trial at this time?

"Yes, the most recent update on clinicaltrials.gov shows that this trial is still searching for participants. The 60 patients needed for the study will be recruited from 3 hospitals or medical clinics."

Answered by AI

How often do people experience negative side effects from AET?

"Although there is safety data for AET, it is only from Phase 2 trials. This means that while we know it's safe, we don't yet have evidence to support its efficacy. Consequently, our team at Power has rated the safety of AET as a 2."

Answered by AI
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~5 spots leftby Mar 2025