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Topical Sodium Nitrite for Leg Ulcers in Sickle Cell Disease
Study Summary
This trial will study whether a topical cream containing sodium nitrite can help heal leg ulcers and decrease pain in patients with sickle cell disease. The cream is applied to the ulcer, and possible side effects include decreased blood pressure and methemoglobinemia.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
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- Group 1: control
- Group 2: topical sodium nitrite
Frequently Asked Questions
To what extent is the community engaging with this research?
"Affirmative. Clinicaltrials.gov evidences that this clinical trial, which was initially advertised on April 6th 2018, is currently recruiting participants. 50 individuals are expected to be enrolled from 2 separate research centres."
Could you elucidate on the potential hazards of Topical Sodium Nitrite?
"Our evaluation of Topical Sodium Nitrite's safety stands at 2, due to the lack of clinical data demonstrating its efficacy yet some evidence pointing towards its basic level of security."
Is this experiment presently open to new participants?
"The data hosted on clinicaltrials.gov indicates that this medical research is actively seeking participants. The study was initially advertised on April 6th, 2018 and the most recent update to its listing occurred on April 5th 2022."
Is this a pioneering trial, or have similar ones been conducted before?
"Research into Topical Sodium Nitrite began in 2016, with Mast Therapeutics Inc. sponsoring the inaugural clinical trial of 35 participants. Following its Phase 1 & 2 approval, there are currently 4 active studies related to this substance being conducted across two cities and one nation."
What prior investigations have been conducted concerning the application of Topical Sodium Nitrite?
"Sodium Nitrite was first studied in 2016 at Children's Hospital of Pittsburgh. 18,341 past trials have been concluded and there are currently 4 active experiments being conducted mostly in the city of Pittsburgh."
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