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Insulin Sensitizer

Metformin for Insulin Resistance

Phase 2
Waitlist Available
Led By K Sreekumaran Nair, M.D., Ph.D.
Research Sponsored by Mayo Clinic
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Non-smoker
English language proficiency
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, 10 months
Awards & highlights

Study Summary

This trial will evaluate the effect of metformin on objective measures of brain aging in a sample of 300 older adults with insulin resistance.

Eligible Conditions
  • Insulin Resistance
  • Obesity
  • Abdominal Obesity

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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You do not smoke.
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You must be able to speak and understand English.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, 10 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, 10 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change from baseline in brain ATP production as measured by phosphorus Magnetic Spectroscopy (31P-MRS) after 10 months of metformin administration
Secondary outcome measures
Change from baseline in brain blood flow as measured by functional MRI after 10 months of metformin administration
Change from baseline in brain structure as measured by functional MRI (fMRI) after 10 months of metformin administration
Change from baseline in cognitive function as measured by NIH Toolbox Cognitive Battery after 10 months of metformin administration
+1 more

Trial Design

2Treatment groups
Active Control
Placebo Group
Group I: MetforminActive Control1 Intervention
Participants in placebo group will receive an escalating dose of Metformin hydrochloride tablets up to a dose of 2500mg for 10 months.
Group II: PlaceboPlacebo Group1 Intervention
Participants in placebo group will receive Placebo Oral Tablets identical to the metformin tablets for 10 months.

Find a Location

Who is running the clinical trial?

Mayo ClinicLead Sponsor
3,183 Previous Clinical Trials
3,758,955 Total Patients Enrolled
20 Trials studying Insulin Resistance
770 Patients Enrolled for Insulin Resistance
National Institute on Aging (NIA)NIH
1,658 Previous Clinical Trials
28,004,441 Total Patients Enrolled
15 Trials studying Insulin Resistance
1,003 Patients Enrolled for Insulin Resistance
K Sreekumaran Nair, M.D., Ph.D.Principal InvestigatorMayo Clinic

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the most common application of Metformin?

"Metformin is frequently prescribed to patients engaging in exercise, as well as those with type 1 diabetes mellitus, diabetic ketoacidosis, and polycystic ovary syndrome."

Answered by AI

How many participants are participating in this experiment?

"Sign-ups for this test are currently closed. It was first announced on March 15th 2019 and last modified on December 7th 2022, so the study is no longer open to new participants. Nevertheless, there are still 1092 clinical trials actively recruiting patients with insulin resistance and 172 studies that can use volunteers taking Metformin."

Answered by AI

Are there still openings available to participate in this clinical investigation?

"Unfortunately, this medical study is not presently enrolling. It was first posted on March 15th 2019 and last changed December 7th 2022. If you are seeking other clinical trials to join, there are 1092 studies actively looking for people who have insulin resistance and 172 that require participants with Metformin experience."

Answered by AI

Are there any adverse effects associated with Metformin usage?

"Given the Stage 2 designation, our team at Power has graded Metformin's safety as a medium-level risk with a score of two. While there is some data detailing its security, none exists to confirm efficacy."

Answered by AI

Are there any additional research initiatives regarding Metformin?

"Currently, 172 trials related to Metformin are in progress with 43 of them being Phase 3 studies. Even though Rockville Maryland is home to the majority of these investigations, 1905 medical centres across the world are running research on this drug."

Answered by AI
~9 spots leftby Mar 2025