CLINICAL TRIAL

High Phosphate Phase for Hypertension

Recruiting · 18+ · All Sexes · Dallas, TX

This study is evaluating whether a high phosphate diet may lead to high blood pressure.

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About the trial for Hypertension

Treatment Groups

This trial involves 2 different treatments. High Phosphate Phase is the primary treatment being studied. Participants will all receive the same treatment. Some patients will receive a placebo treatment. The treatments being tested are in Phase 2 and have already been tested with other people.

Main TreatmentA portion of participants receive this new treatment to see if it outperforms the control.
High Phosphate Phase
DIETARYSUPPLEMENT
Control TreatmentAnother portion of participants receive the standard treatment to act as a baseline.
Low Phosphate Phase
DIETARYSUPPLEMENT

Eligibility

This trial is for patients born any sex aged 18 and older. There are 3 eligibility criteria to participate in this trial as listed below.

Inclusion & Exclusion Checklist
Mark “yes” if the following statements are true for you:
Inclusion Criteria: (answer must be yes to all to enter trial; check yes or no)
º ≥ 18 years of age
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Odds of Eligibility
Unknown<50%
Be sure to apply to 2-3 other trials, as you have a low likelihood of qualifying for this one.Apply To This Trial
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Approximate Timelines

Please note that timelines for treatment and screening will vary by patient
Screening: ~3 weeks
Treatment: varies
Reporting: 4 weeks after high phosphorus and 4 weeks after low phosphorus diet
This trial has approximate timelines as follows: 3 weeks for initial screening, variable treatment timelines, and reporting: 4 weeks after high phosphorus and 4 weeks after low phosphorus diet.
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Measurement Requirements

This trial is evaluating whether High Phosphate Phase will improve 1 primary outcome and 1 secondary outcome in patients with Hypertension. Measurement will happen over the course of 4 weeks.

24-hour Blood Pressure measured by Ambulatory Blood Pressure Monitor.
4 WEEKS
Blood pressure will be measured through an ambulatory blood pressure monitoring device by Space Labs # 90217, worn by each participant after completing each phase, This will suggest if participant's blood pressure increased during high phosphorus phase as compared to low phosphorus phase.
Muscle Sympathetic Nerve Activity (MSNA)
4 WEEKS AFTER HIGH PHOSPHORUS AND 4 WEEKS AFTER LOW PHOSPHORUS DIET
MSNA will be measured during both diet phases using microelectrodes inserted in the peroneal nerve. This will assess the impact of phosphate intake on MSNA.

Who is running the study

Principal Investigator
W. V.
Prof. Wanpen Vongpatanasin, Professor of Medicine
University of Texas Southwestern Medical Center

Patient Q & A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the signs of hypertension?

The symptoms of hypertension are headache and visual field defects. When asked to look for swelling behind the eye and/or a bulging (puffy) and red (hot) face, patients may not interpret this as a sign of hypertension.\n

Anonymous Patient Answer

What is hypertension?

Hypertension is the most prevalent cause of death among persons aged 65 years or older in the US. It is also of interest that many people, regardless of age, show evidence of hypertension but are unaware of their status. Preventing hypertension is important for individuals and for society as a whole.

Anonymous Patient Answer

How many people get hypertension a year in the United States?

It is important that the health professionals at the ambulatory clinics keep an eye out and advise them about hypertension so that they can control their blood pressure by medication. This can be done through the screening and testing of them and even by offering them information about how to manage their blood pressure. The ultimate goal is to prevent heart failure and strokes.

Anonymous Patient Answer

Can hypertension be cured?

There is a theoretical possibility (at least in principle) with an appropriate regimen to eliminate hypertension, at least among the group with high pretreatment blood pressure – though most of the patients will require combination therapy. The study results should be interpreted with caution, considering the low number of participants, and the small absolute reduction in BP values achieved by the protocol itself. The authors do not recommend using this protocol as an alternative treatment for hypertensive patients.

Anonymous Patient Answer

What causes hypertension?

All hypertensive patients need to be evaluated for the presence of heart defects and renal anomalies as these diseases can have an important effect on the progression of hypertension.

Anonymous Patient Answer

What are common treatments for hypertension?

The most common medication for the treatment of hypertension is an antihypertensive medication, including nitroprusside, indapamide, losartan, lisinopril, and atenolol. Some patients may require the administration of alpha and/or beta blockers. A few patients may benefit from beta blockers in combination with other drugs like a diuretic to help manage high blood pressure.

Anonymous Patient Answer

What are the latest developments in high phosphate phase for therapeutic use?

Current data do not provide an evidence to support a new therapy modality with the potential to overcome the limitation that has limited the use of phosphate-lowering therapy in clinical practice. Nevertheless, future improvements in therapy development will be crucial to improve the effectiveness of therapies using phosphate-lowering therapy.

Anonymous Patient Answer

What is the latest research for hypertension?

There is no systematic review. What little is described are mostly short studies and studies with small sample size which do indicate that it is important to keep the body of research up to date.

Anonymous Patient Answer

Who should consider clinical trials for hypertension?

The role of clinical trials in decision-making in treating hypertension should be examined. There are substantial differences between countries regarding current practice of managing hypertension. Clinical trials on people with diabetes and on atrial fibrillation are needed to further increase the effectiveness of hypertension treatment.

Anonymous Patient Answer

Has high phosphate phase proven to be more effective than a placebo?

Although the higher dosage of amiloride proved superior to the placebo in reducing the occurrence of nocturnal hypoxaemia, there was no evidence of superiority with respect to prevention of nocturnal hypertension. Higher phosphate bicarbonate treatment was found to be more effective than placebo in maintaining renal function and improving the urinary losses of ammonium, but there was no difference between higher and lower phosphate bicarbonate treatments in preventing the occurrence of hypoxaemia. In conclusion, no firm conclusion could be made as to whether amiloride was superior to placebo in preventing nocturnal hypotension, but both seemed effective in improving the urinary losses of ammonium.

Anonymous Patient Answer

What is high phosphate phase?

In subjects with type 2 diabetes on insulin therapy, the high phosphate phase of type 2 diabetes is characterized by hyperphosphaturia and an increased risk of the development of microvascular complications. This finding was unexpected.

Anonymous Patient Answer

How serious can hypertension be?

The clinical presentation of hypertension can vary significantly with the age of the individual. Most individuals with hypertension only have mild symptoms, but in patients as old as 70 to 90 years old with uncomplicated hypertension, there may be signs and symptoms of heart disease with more serious consequences.

Anonymous Patient Answer
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