← Back to Search

Phosphate Binder

High Phosphate Phase for High Blood Pressure

Phase 2
Waitlist Available
Led By Wapen Vongpatanasin, MD
Research Sponsored by University of Texas Southwestern Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
º Stage 1 Prehypertension (office BP 120-129/80-84 mmHg and normal ABPM <130/80)
Inclusion Criteria: (answer must be yes to all to enter trial; check yes or no)
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 4 weeks after high phosphorus and 4 weeks after low phosphorus diet
Awards & highlights

Study Summary

This trial will investigate the role of high phosphate diet in human hypertension and assess the effect of high phosphate diet on muscle sympathetic nerve activity and the exercise pressor reflex.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~4 weeks after high phosphorus and 4 weeks after low phosphorus diet
This trial's timeline: 3 weeks for screening, Varies for treatment, and 4 weeks after high phosphorus and 4 weeks after low phosphorus diet for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
24-hour Blood Pressure measured by Ambulatory Blood Pressure Monitor.
Secondary outcome measures
Muscle Sympathetic Nerve Activity (MSNA)

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: High Phosphate PhaseExperimental Treatment1 Intervention
All subjects will be on a low Pi diet containing 700mg/day of phosphate and 2 capsules of sodium phosphate with 500mg/day of phosphate for 4 weeks.
Group II: Low Phosphate PhasePlacebo Group1 Intervention
All subjects will be on a low Pi diet containing 700mg/day of phosphate and 2 capsules of sodium chloride for 4 weeks.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
High Phosphate Phase
2017
Completed Phase 2
~100

Find a Location

Who is running the clinical trial?

University of Texas Southwestern Medical CenterLead Sponsor
1,040 Previous Clinical Trials
1,048,012 Total Patients Enrolled
Wapen Vongpatanasin, MDPrincipal InvestigatorUT southwestern

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
~13 spots leftby Mar 2025