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Oral Immunotherapy

Cashew or Shrimp Oral Immunotherapy for Food Allergy (MOTIF Trial)

Phase 2
Waitlist Available
Research Sponsored by Kari Christine Nadeau, MD, PhD
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Clinical history of allergy to cashew or shrimp-containing foods
Be younger than 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, week 52 and week 58
Awards & highlights

MOTIF Trial Summary

This trial is testing if cashew or shrimp OIT can help people with allergies to either cashew or shrimp. 72 participants will be treated and the trial will use DBPCFC, allergy history, clinical symptoms, and food-allergen specific IgE levels to determine if the treatment is working.

Eligible Conditions
  • Food Allergy
  • Shrimp Allergy
  • Cashew Nut Allergy

MOTIF Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
You have had an allergic reaction to cashews or shrimp in the past.

MOTIF Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, week 52 and week 58
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, week 52 and week 58 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Expression of CD28 in the CD4+ Allergen Specific (CD154+)
Secondary outcome measures
Expression of CD28+ Allergen Specific (CD154+) T-cells
Expression of the Mechanistic Marker Via Flow Cytometry
Expression of the Mechanistic Markers Vis Luminex Assay

MOTIF Trial Design

1Treatment groups
Experimental Treatment
Group I: Cashew or Shrimp Oral ImmunotherapyExperimental Treatment1 Intervention
Participants, ages 7 to 55 years, inclusive, with an allergy to Cashew or Shrimp.

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Who is running the clinical trial?

Kari Christine Nadeau, MD, PhDLead Sponsor
1 Previous Clinical Trials
875 Total Patients Enrolled
Sayantani B. SindherLead Sponsor
1 Previous Clinical Trials
875 Total Patients Enrolled
National Institute of Allergy and Infectious Diseases (NIAID)NIH
3,262 Previous Clinical Trials
5,483,755 Total Patients Enrolled
12 Trials studying Food Allergy
12,258 Patients Enrolled for Food Allergy

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is the eligibility for this trial limited to adults only?

"Patients aged between 7 and 55 years old are eligible to partake in this trial."

Answered by AI

Do I fulfill the qualifications to partake in this research?

"The eligibility requirements for this study necessitates that applicants be allergic to shrimp and between the ages of 7 and 55. There are currently 52 positions open to participants."

Answered by AI

Has the Food and Drug Administration given authorization to Cashew or Shrimp Oral Immunotherapy?

"Our staff has assigned Cashew or Shrimp Oral Immunotherapy a rating of 2 out of 3 due to its current status as a Phase 2 trial. This suggests that there is some evidence for safety, but no proof yet demonstrating efficacy."

Answered by AI

Are patients still eligible to participate in this experiment?

"According to clinicaltrials.gov, this particular trial has concluded its recruitment process for the time being and was last updated in May 2021. Nevertheless, there are still 261 other medical studies actively seeking participants at present."

Answered by AI
~10 spots leftby Mar 2025