This trial is evaluating whether Flutamide will improve 1 primary outcome and 4 secondary outcomes in patients with Adrenal Hyperplasia, Congenital. Measurement will happen over the course of at 13 for boys; 14 for girls.
This trial requires 62 total participants across 2 different treatment groups
This trial involves 2 different treatments. Flutamide is the primary treatment being studied. Participants will be divided into 2 treatment groups. There is no placebo group. The treatments being tested are in Phase 2 and have already been tested with other people.
"A combination of metyrapone, fludrocortisone, and chlorotrianisene is effective in the treatment of familial and neonatal cases of primary aldosteronism, but the role of surgery to treat disease in other ages can be doubtful. The exact role and timing of treatment may need to be individualized in order to maximize the extent of tumor reduction while maintaining the patient's life and preserving the adrenal gland from further damage." - Anonymous Online Contributor
"Flutamide has been the only drug used or proposed for use on a regular basis for the treatment of hirsutism for a number of years. These data are similar to those published by the United States Food and Drug Administration in the absence of safety monitoring. The inclusion of flutamide in the treatment of hirsutism on a more regular basis may be a cost-effective solution to a problem which is significant to several societies." - Anonymous Online Contributor
"Adrenal hyperplasia, congenital can be described as an accumulation or overactivity of an adrenal gland that releases certain hormones during infancy or early childhood (e.g., cortisol in the blood). The symptoms and signs of adrenal hyperplasia, congenital can vary, depending on which of the adrenocortical glands is affected." - Anonymous Online Contributor
"There is a high percentage of adrenal hyperplasia, congenital in patients with isolated growth hormone deficient dwarfism. The clinical picture, in other words the clinical picture of the disease, and the hormonal assay can suggest a diagnosis, but a precise demonstration of a specific gene for a case of isolated growth hormone-deficient dwarfism needs to be made." - Anonymous Online Contributor
"1.3 million individuals in the United States are diagnosed with adrenal hyperplasia. This makes up 21% of the total population of pediatric endocrinology in the United States." - Anonymous Online Contributor
"Corticosteroids are most effective in the treatment of congenital adrenal hyperplasia, and often reduce the need for surgical correction. Corticosteroids are often prescribed with anabolic steroid and mineralocorticoid blockade. Steroids are often used to treat hyperprostasemia, with or without adrenal atrophy. Mineralocorticoid blockers may be used alone and in combinations with other drugs." - Anonymous Online Contributor
"Signs of adrenal insufficiency may include weakness, pale skin, pallor and increased thirst, urination, fatigue, lack of appetite, diarrhea, constipation and vomiting. In severe cases, shock may occur.\n" - Anonymous Online Contributor
"There have been few other clinical trials involving flutamide. In those trials, the results suggest that it has been well tolerated but does not seem to improve outcomes. However, because we do not have a large body of clinical studies, we cannot assess the potential effects of flutamide in terms of safety. This question will have to be asked in future studies using flutamide." - Anonymous Online Contributor
"The present study demonstrates that flutamide causes a decrease in sex hormone levels. In addition, it reduces gonadal and adrenal androgen levels, while there is an increment in the levels of cortisol. flutamide also reverses hyperprolactinemia in male rats. Results from a recent paper also show that flutamide has a direct negative effect on prolactin secretion in the rat anterior pituitary gland. Taken together, these results indicate that flutamide causes an androgen depletion in the gonads and adrenals and is also able to reduce prolactin production. Moreover, it seems that flutamide influences the dopaminergic neuron, possibly mediated by its action on the gonadal and adrenal steroid levels." - Anonymous Online Contributor
"[Adrenal hyperplasia, congenital is the most common type of hyperfunction and it is also more serious as the defect in adrenal secretion is congenital or in part. Patients should be diagnosed early to give them effective treatment and prevention of complications] according to previous study [(3)3] answer: None of our recent findings is new for treating adrenal hyperplasia, congenital. It is important to note that adrenal hyperplasia, congenital patients could also have other problems besides adrenal hyperplasia, congenital such as primary or secondary hyperaldosteronism, and Addison's disease." - Anonymous Online Contributor
"Adrenal hyperplasia presents on average for younger children (about 1 year old). Symptoms usually appear within the first year of life. More information is available on adrenal hyperplasia at [U.S. National Cancer Institute] (http://www.hbpcdc.nih.gov/about/about/hbpcdc/about/hbpcdc/about/about_pregnancy.htm) and [U.S. National Library of Medicine's] (http://www.nlm.nih.gov/about/medical/conditions/about_adrenal_hyp.html)." - Anonymous Online Contributor
"Adrenal hyperplasia, congenital has a autosomal dominant inheritance pattern. We suggest that adrenal hyperplasia, congenital (ADHOC) run in families warrants further investigation involving other siblings of the probands as to whether this is a common occurrence in adrenal hyperplasia, congenital." - Anonymous Online Contributor