adalimumab for Nephrotic Syndrome

Phase-Based Progress Estimates
1
Effectiveness
2
Safety
Medical University of South Carolina, Charleston, SC
Nephrotic Syndrome+6 More
adalimumab - Drug
Eligibility
Any Age
All Sexes
Eligible conditions
Select

Study Summary

This study is evaluating whether a medication which blocks tumor necrosis factor (TNF), a protein which is elevated in individuals with kidney disease, may help treat kidney disease. original:

See full description

Eligible Conditions

  • Nephrotic Syndrome
  • Focal Segmental Glomerulosclerosis (FSGS)
  • FSGS
  • MCD

Treatment Effectiveness

Effectiveness Progress

1 of 3

Other trials for Nephrotic Syndrome

Study Objectives

This trial is evaluating whether adalimumab will improve 2 primary outcomes and 4 secondary outcomes in patients with Nephrotic Syndrome. Measurement will happen over the course of Baseline, Week 10.

Baseline, Week 10
Change in urine MCP1/Cr levels
Change in urine TIMP1/Cr levels
Percent change in Urine Protein Creatinine Ratio (UPC)
Percent change of estimated glomerular filtration rate (eGFR)
Through study week 14
Incidence adverse events (AEs)
Week 10
Proportion of participants achieving a nadir Urine Protein Creatinine Ratio (UPC) less than 1.5 g/g and at least a 40% reduction from baseline

Trial Safety

Safety Progress

2 of 3
This is further along than 68% of similar trials

Other trials for Nephrotic Syndrome

Side Effects for

Tofacitinib 5 mg BID
Upper respiratory tract infection
22%
Bronchitis
15%
Urinary tract infection
13%
Rheumatoid arthritis
13%
Nasopharyngitis
12%
Fall
12%
Herpes zoster
12%
Hypertension
9%
Arthralgia
8%
Lymphopenia
7%
Sinusitis
7%
Back pain
7%
Diarrhoea
7%
Influenza
6%
Latent tuberculosis
6%
Pharyngitis
6%
Osteoarthritis
6%
Anaemia
5%
Nausea
5%
Alanine aminotransferase increased
5%
Cough
5%
Gastroenteritis
4%
Pneumonia
3%
Headache
3%
Coronary artery disease
1%
Cellulitis
1%
Femur fracture
1%
Pulmonary embolism
1%
Bronchiolitis
0%
Peritonitis
0%
Loss of consciousness
0%
Cardiac arrest
0%
Death
0%
Neurocryptococcosis
0%
Septic shock
0%
Sinusitis fungal
0%
Cytopenia
0%
Soft tissue infection
0%
Parainfluenzae virus infection
0%
Agranulocytosis
0%
Disseminated intravascular coagulation
0%
Tick-borne fever
0%
Iron deficiency anaemia
0%
Haemolytic anaemia
0%
Parotid abscess
0%
Sinobronchitis
0%
Parotitis
0%
Pelvic abscess
0%
Pericarditis tuberculous
0%
Leukocytosis
0%
Leukopenia
0%
Acute coronary syndrome
0%
Aortic valve disease
0%
Neutropenia
0%
Lymphadenopathy
0%
Pancytopenia
0%
Angina unstable
0%
Tooth abscess
0%
Acute left ventricular failure
0%
Angina pectoris
0%
Arrhythmia
0%
Arrhythmia supraventricular
0%
Atrial fibrillation
0%
Atrial flutter
0%
Pelvic inflammatory disease
0%
Cardio-respiratory arrest
0%
Cardiovascular insufficiency
0%
Cardiac failure
0%
Coronary artery occlusion
0%
Cardiac failure chronic
0%
Pneumocystis jirovecii pneumonia
0%
Tracheobronchitis
0%
Cardiac failure acute
0%
Congestive cardiomyopathy
0%
Cardiomyopathy
0%
Cardiac failure congestive
0%
Cardiac pseudoaneurysm
0%
Myocardial ischaemia
0%
Coronary artery insufficiency
0%
Ischaemic cardiomyopathy
0%
Pneumonia bacterial
0%
Pericarditis
0%
Diastolic dysfunction
0%
Supraventricular tachycardia
0%
Ventricular tachycardia
0%
Corneal dystrophy
0%
Pneumonia fungal
0%
Myocardial infarction
0%
Right ventricular dysfunction
0%
Pneumonia influenzal
0%
Sinus node dysfunction
0%
Ventricular fibrillation
0%
Pneumonia legionella
0%
Exomphalos
0%
Tuberculosis
0%
Adrenal disorder
0%
Developmental hip dysplasia
0%
Vestibular disorder
0%
Pneumonia mycoplasmal
0%
Meniere's disease
0%
Diabetic retinopathy
0%
Retinal vasculitis
0%
Acute vestibular syndrome
0%
Pneumonia pneumococcal
0%
Vertigo
0%
Thyroid mass
0%
Adrenal haematoma
0%
Hyperthyroidism
0%
Episcleritis
0%
Necrotising retinitis
0%
Keratoconus
0%
Chronic gastritis
0%
Pneumonia staphylococcal
0%
Post procedural pneumonia
0%
Post procedural sepsis
0%
Abdominal hernia
0%
Abdominal pain
0%
Macular hole
0%
Abdominal discomfort
0%
Staphylococcal sepsis
0%
Retinal detachment
0%
Ascites
0%
Ulcerative keratitis
0%
Abdominal pain upper
0%
Abdominal compartment syndrome
0%
Abdominal incarcerated hernia
0%
Rectal abscess
0%
Renal abscess
0%
Retroperitoneal abscess
0%
Pyelonephritis
0%
Respiratory tract infection viral
0%
Duodenal stenosis
0%
Diverticular perforation
0%
Colitis ischaemic
0%
Constipation
0%
Enterocolitis
0%
Faecaloma
0%
Gastritis erosive
0%
Gastric polyps
0%
Duodenal ulcer haemorrhage
0%
Gastritis haemorrhagic
0%
Gastrooesophageal reflux disease
0%
Pulmonary tuberculosis
0%
Gastric ulcer haemorrhage
0%
Gastrointestinal erosion
0%
Gastrointestinal inflammation
0%
Intestinal obstruction
0%
Intestinal ischaemia
0%
Gastrointestinal haemorrhage
0%
Ileus
0%
Ischaemic enteritis
0%
Pulpitis dental
0%
Pyometra
0%
Haematochezia
0%
Impaired gastric emptying
0%
Melaena
0%
Inguinal hernia
0%
Jejunal ulcer perforation
0%
Irritable bowel syndrome
0%
Large intestine perforation
0%
Systemic candida
0%
Large intestinal ulcer
0%
Mallory-Weiss syndrome
0%
Obstruction gastric
0%
Obstructive pancreatitis
0%
Obturator hernia
0%
Peptic ulcer perforation
0%
Pancreatitis acute
0%
Oesophagitis
0%
Mesenteric vein thrombosis
0%
Rectal haemorrhage
0%
Oesophageal food impaction
0%
Peptic ulcer haemorrhage
0%
Pancreatitis
0%
Pancreatitis chronic
0%
Pancreatitis haemorrhagic
0%
Peptic ulcer
0%
Vomiting
0%
Small intestinal obstruction
0%
Thrombosis mesenteric vessel
0%
Umbilical hernia
0%
Device intolerance
0%
Small intestinal perforation
0%
Accidental death
0%
Chest discomfort
0%
Upper gastrointestinal haemorrhage
0%
Adverse drug reaction
0%
Complication associated with device
0%
Chest pain
0%
Drug intolerance
0%
Inflammation
0%
Impaired healing
0%
Hepatic cirrhosis
0%
Mucosal inflammation
0%
Cholangitis
0%
Cholecystitis
0%
Oedema peripheral
0%
Systemic inflammatory response syndrome
0%
Cirrhosis alcoholic
0%
Bile duct stone
0%
Pyrexia
0%
Biliary colic
0%
Cholecystitis chronic
0%
Sudden death
0%
Cholecystitis acute
0%
Drug-induced liver injury
0%
Appendicitis perforated
0%
Bronchitis bacterial
0%
Cholelithiasis
0%
Drug hypersensitivity
0%
Gallbladder obstruction
0%
Hepatotoxicity
0%
Anaphylactic shock
0%
Adenovirus infection
0%
Hypertransaminasaemia
0%
Anaphylactic reaction
0%
Hypersensitivity
0%
Gallbladder rupture
0%
Hepatorenal failure
0%
Abscess
0%
Acute pulmonary histoplasmosis
0%
Appendiceal abscess
0%
Anal abscess
0%
Atypical pneumonia
0%
Arthritis bacterial
0%
Acute sinusitis
0%
Appendicitis
0%
Bacterial sepsis
0%
Bone tuberculosis
0%
Brain abscess
0%
Renal tuberculosis
0%
Respiratory tract infection
0%
Arthritis infective
0%
Bacteraemia
0%
Breast abscess
0%
Bronchopulmonary aspergillosis
0%
COVID-19 pneumonia
0%
Dengue fever
0%
Erysipelas
0%
COVID-19
0%
Chorioretinitis
0%
Gastroenteritis viral
0%
Bronchitis viral
0%
Bursitis infective
0%
Cellulitis staphylococcal
0%
Cytomegalovirus chorioretinitis
0%
Sepsis
0%
Colonic abscess
0%
Gangrene
0%
Carbuncle
0%
Cholecystitis infective
0%
Diarrhoea infectious
0%
Disseminated varicella zoster virus infection
0%
Encephalitis meningococcal
0%
Epididymitis
0%
Cytomegalovirus infection
0%
Escherichia pyelonephritis
0%
Herpes oesophagitis
0%
Device related infection
0%
Disseminated tuberculosis
0%
Escherichia urinary tract infection
0%
External ear cellulitis
0%
Escherichia bacteraemia
0%
Escherichia infection
0%
Escherichia sepsis
0%
Extradural abscess
0%
Eye infection
0%
Localised infection
0%
Gastroenteritis bacterial
0%
H1N1 influenza
0%
Infected bite
0%
Infection
0%
Liver abscess
0%
Gastrointestinal infection
0%
Histoplasmosis
0%
Infectious pleural effusion
0%
Herpes ophthalmic
0%
Herpes virus infection
0%
Lung abscess
0%
Lyme disease
0%
Medical device site joint infection
0%
Salmonella sepsis
0%
Lower respiratory tract infection
0%
Meningitis bacterial
0%
Meningoencephalitis herpetic
0%
Nail infection
0%
Peritoneal tuberculosis
0%
Muscle abscess
0%
Ophthalmic herpes zoster
0%
Orchitis
0%
Neuroborreliosis
0%
Osteomyelitis
0%
Urosepsis
0%
Viral infection
0%
Tubo-ovarian abscess
0%
Alcohol poisoning
0%
Wound infection staphylococcal
0%
Wound sepsis
0%
Acetabulum fracture
0%
Ankle fracture
0%
Contusion
0%
Extradural haematoma
0%
Femoral neck fracture
0%
Central cord syndrome
0%
Complicated fracture
0%
Fibula fracture
0%
Foot fracture
0%
Forearm fracture
0%
Fracture
0%
Graft complication
0%
Hand fracture
0%
Head injury
0%
Hip fracture
0%
Humerus fracture
0%
Incisional hernia
0%
Injury
0%
Limb traumatic amputation
0%
Lower limb fracture
0%
Lumbar vertebral fracture
0%
Multiple fractures
0%
Muscle rupture
0%
Patella fracture
0%
Pelvic fracture
0%
Periprosthetic fracture
0%
Post laminectomy syndrome
0%
Post procedural haemorrhage
0%
Postoperative wound complication
0%
Radius fracture
0%
Respiratory fume inhalation disorder
0%
Rib fracture
0%
Road traffic accident
0%
Skin laceration
0%
Skin wound
0%
Spinal compression fracture
0%
Spinal fracture
0%
Subarachnoid haematoma
0%
Subdural haematoma
0%
Tendon rupture
0%
Thermal burn
0%
Tibia fracture
0%
Transplant dysfunction
0%
Ulna fracture
0%
Upper limb fracture
0%
Wound dehiscence
0%
Wound necrosis
0%
Wrist fracture
0%
Aspartate aminotransferase increased
0%
Biopsy endometrium normal
0%
Blood alkaline phosphatase increased
0%
Blood sodium decreased
0%
Hepatic enzyme increased
0%
International normalised ratio increased
0%
Lymphocyte count decreased
0%
Transaminases increased
0%
Dehydration
0%
Diabetes mellitus
0%
Diabetes mellitus inadequate control
0%
Diabetic ketoacidosis
0%
Fluid overload
0%
Hypercalcaemia
0%
Hyperglycaemia
0%
Hyperglycaemic hyperosmolar nonketotic syndrome
0%
Hyperkalaemia
0%
Hypernatraemia
0%
Hypertriglyceridaemia
0%
Hypochloraemia
0%
Hypoglycaemia
0%
Hypokalaemia
0%
Hyponatraemia
0%
Ketoacidosis
0%
Bone disorder
0%
Bone hypertrophy
0%
Bursitis
0%
Cervical spinal stenosis
0%
Costochondritis
0%
Dupuytren's contracture
0%
Haemarthrosis
0%
Hip deformity
0%
Intervertebral disc degeneration
0%
Intervertebral disc disorder
0%
Intervertebral disc protrusion
0%
Joint contracture
0%
Joint destruction
0%
Joint instability
0%
Lumbar spinal stenosis
0%
Muscle tightness
0%
Muscular weakness
0%
Musculoskeletal chest pain
0%
Musculoskeletal pain
0%
Myalgia
0%
Myopathy
0%
Neck pain
0%
Osteonecrosis
0%
Pathological fracture
0%
Pseudarthrosis
0%
Rhabdomyolysis
0%
Rotator cuff syndrome
0%
Spinal instability
0%
Spinal osteoarthritis
0%
Spinal pain
0%
Spinal stenosis
0%
Spondyloarthropathy
0%
Synovial cyst
0%
Synovial disorder
0%
Tendon disorder
0%
Tendonitis
0%
Tenosynovitis
0%
Thoracic spinal stenosis
0%
Abdominal neoplasm
0%
Adenoma benign
0%
Anogenital warts
0%
B-cell lymphoma
0%
Basal cell carcinoma
0%
Bladder neoplasm
0%
Breast cancer
0%
Cholesteatoma
0%
Chronic lymphocytic leukaemia
0%
Colon neoplasm
0%
Diffuse large B-cell lymphoma
0%
Extranodal marginal zone B-cell lymphoma (MALT type)
0%
Gallbladder neoplasm
0%
Gastrointestinal lymphoma
0%
Heavy chain disease
0%
Lipoma
0%
Lung neoplasm
0%
Lymphoma
0%
Lymphoproliferative disorder
0%
Malignant melanoma
0%
Malignant neoplasm of pleura
0%
Meningioma
0%
Meningioma benign
0%
Metastatic neoplasm
0%
Neoplasm
0%
Neuroendocrine carcinoma of the skin
0%
Non-Hodgkin's lymphoma
0%
Ovarian adenoma
0%
Ovarian granulosa cell tumour
0%
Ovarian neoplasm
0%
Plasma cell myeloma
0%
Prostate cancer
0%
Rectal adenoma
0%
Rectal cancer
0%
Rectosigmoid cancer
0%
Renal cancer
0%
Schwannoma
0%
Skin cancer
0%
Squamous cell carcinoma
0%
Squamous cell carcinoma of lung
0%
Squamous cell carcinoma of skin
0%
Sweat gland tumour
0%
Thyroid cancer
0%
Uterine leiomyoma
0%
Waldenstrom's macroglobulinaemia
0%
Basilar artery stenosis
0%
Carotid artery occlusion
0%
Carotid artery stenosis
0%
Cerebral ischaemia
0%
Cerebrovascular accident
0%
Cerebrovascular disorder
0%
Cervical cord compression
0%
Cervical radiculopathy
0%
Coma hepatic
0%
Dementia
0%
Dementia Alzheimer's type
0%
Diabetic neuropathy
0%
Dizziness
0%
Encephalopathy
0%
Epilepsy
0%
Facial paralysis
0%
Guillain-Barre syndrome
0%
Hepatic encephalopathy
0%
Hypoaesthesia
0%
Hypoglycaemic seizure
0%
Intercostal neuralgia
0%
Intracranial mass
0%
Ischaemic stroke
0%
Lumbar radiculopathy
0%
Lumbosacral radiculopathy
0%
Metabolic encephalopathy
0%
Migraine
0%
Morton's neuralgia
0%
Myelopathy
0%
Neuralgia
0%
Paraesthesia
0%
Peripheral sensorimotor neuropathy
0%
Post herpetic neuralgia
0%
Postictal paralysis
0%
Presyncope
0%
Progressive supranuclear palsy
0%
Quadriplegia
0%
Radiculopathy
0%
Restless legs syndrome
0%
Reversible ischaemic neurological deficit
0%
Ruptured cerebral aneurysm
0%
Sciatica
0%
Seizure
0%
Spinal claudication
0%
Spondylitic myelopathy
0%
Status epilepticus
0%
Syncope
0%
Thecal sac compression
0%
Toxic encephalopathy
0%
Transient ischaemic attack
0%
Vascular encephalopathy
0%
Device dislocation
0%
Device failure
0%
Device loosening
0%
Anxiety
0%
Completed suicide
0%
Confusional state
0%
Delirium
0%
Depression
0%
Major depression
0%
Mental status changes
0%
Psychotic disorder
0%
Suicidal ideation
0%
Suicide attempt
0%
Acute kidney injury
0%
Calculus urinary
0%
Chronic kidney disease
0%
End stage renal disease
0%
Focal segmental glomerulosclerosis
0%
Glomerulonephritis
0%
Hydronephrosis
0%
Nephrolithiasis
0%
Renal atrophy
0%
Renal colic
0%
Renal cyst
0%
Renal failure
0%
Renal impairment
0%
Renal injury
0%
Stress urinary incontinence
0%
Ureterolithiasis
0%
Urethral stenosis
0%
Urinary retention
0%
Benign prostatic hyperplasia
0%
Cystocele
0%
Dysfunctional uterine bleeding
0%
Endometrial hyperplasia
0%
Endometrial hypertrophy
0%
Genital prolapse
0%
Orchitis noninfective
0%
Ovarian cyst
0%
Postmenopausal haemorrhage
0%
Uterine polyp
0%
Uterovaginal prolapse
0%
Vaginal prolapse
0%
Acute pulmonary oedema
0%
Acute respiratory distress syndrome
0%
Acute respiratory failure
0%
Aspiration
0%
Asthma
0%
Asthmatic crisis
0%
Bronchospasm
0%
Chronic obstructive pulmonary disease
0%
Dyspnoea
0%
Epistaxis
0%
Haemoptysis
0%
Hypoxia
0%
Interstitial lung disease
0%
Lung disorder
0%
Nasal septum deviation
0%
Obstructive airways disorder
0%
Organising pneumonia
0%
Pickwickian syndrome
0%
Pneumonia aspiration
0%
Pneumonitis
0%
Pneumothorax
0%
Pulmonary oedema
0%
Pulmonary thrombosis
0%
Respiratory acidosis
0%
Respiratory depression
0%
Respiratory failure
0%
Rheumatoid lung
0%
Status asthmaticus
0%
Actinic keratosis
0%
Erythema
0%
Rash papular
0%
Urticaria
0%
Aortic intramural haematoma
0%
Aortic occlusion
0%
Aortic stenosis
0%
Aortitis
0%
Circulatory collapse
0%
Deep vein thrombosis
0%
Extremity necrosis
0%
Femoral artery embolism
0%
Haematoma
0%
Haemorrhage
0%
Hypertensive emergency
0%
Hypertensive urgency
0%
Hypotension
0%
Hypovolaemic shock
0%
Iliac artery occlusion
0%
Labile blood pressure
0%
Peripheral artery occlusion
0%
Peripheral ischaemia
0%
Peripheral vascular disorder
0%
Phlebitis
0%
Shock
0%
Shock haemorrhagic
0%
Superior vena cava syndrome
0%
Thrombophlebitis
0%
Thrombophlebitis superficial
0%
Thrombosis
0%
Varicose ulceration
0%
Varicose vein
0%
Vasculitis
0%
Venous thrombosis
0%
Venous thrombosis limb
0%
Blood loss anaemia
0%
Atrioventricular block
0%
Chronic left ventricular failure
0%
Mitral valve disease
0%
Coronary artery stenosis
0%
Hydrocele
0%
Abdominal distension
0%
Gastric ulcer
0%
Gastritis
0%
Hiatus hernia
0%
Jejunal ulcer
0%
Asthenia
0%
Multiple organ dysfunction syndrome
0%
Non-cardiac chest pain
0%
Chronic sinusitis
0%
Clostridium difficile colitis
0%
Complicated appendicitis
0%
Abscess limb
0%
Diverticulitis
0%
Bacterial infection
0%
Perihepatic abscess
0%
Joint abscess
0%
Osteomyelitis acute
0%
Post procedural infection
0%
Intervertebral discitis
0%
Postoperative wound infection
0%
Pyelonephritis acute
0%
Wound infection
0%
Accidental overdose
0%
Back injury
0%
Clavicle fracture
0%
Concussion
0%
Joint dislocation
0%
Limb injury
0%
Meniscus injury
0%
Procedural pneumothorax
0%
Pulmonary contusion
0%
Blood creatine phosphokinase increased
0%
Weight decreased
0%
Decreased appetite
0%
Electrolyte imbalance
0%
Vitamin D deficiency
0%
Arthritis
0%
Exostosis
0%
Knee deformity
0%
Spondylolisthesis
0%
Lung neoplasm malignant
0%
Amyotrophic lateral sclerosis
0%
Intracranial aneurysm
0%
Senile dementia
0%
Subarachnoid haemorrhage
0%
Device occlusion
0%
Bladder diverticulum
0%
Cervical polyp
0%
Endometrial thickening
0%
Bronchiectasis
0%
Pleural effusion
0%
Pleurisy
0%
Decubitus ulcer
0%
Hypertensive crisis
0%
Colitis
0%
Cataract
0%
Uveitis
0%
Dysphagia
0%
Enteritis
0%
Fistula
0%
Foot deformity
0%
Kyphosis
0%
This histogram enumerates side effects from a completed 2020 Phase 4 trial (NCT02092467) in the Tofacitinib 5 mg BID ARM group. Side effects include: Upper respiratory tract infection with 22%, Bronchitis with 15%, Urinary tract infection with 13%, Rheumatoid arthritis with 13%, Nasopharyngitis with 12%.

Trial Design

1 Treatment Group

adalimumab
1 of 1
Experimental Treatment

This trial requires 8 total participants across 1 different treatment group

This trial involves a single treatment. Adalimumab is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase 2 and have already been tested with other people.

adalimumab
Drug
Adalimumab dose every other week (study weeks 0, 2, 4, 6, and 8), subcutaneously
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Adalimumab
FDA approved

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: through study week 14
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly through study week 14 for reporting.

Who is running the study

Principal Investigator
D. G.
Prof. Debbie Gipson, MD
University of Michigan

Closest Location

Medical University of South Carolina - Charleston, SC

Eligibility Criteria

This trial is for patients born any sex of any age. There are 10 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
to assess for the presence of actionable genomic alterations show original
is an indicator for significant proteinuria Urine protein to creatinine ratio of 1.5 or more is an indicator of significant proteinuria. show original
The weight of an object is greater than 15 kg. show original
People who are taking angiotensin converting enzyme inhibitors, angiotensin receptor blockers, or oral immunosuppression agents for at least 30 days prior to enrollment are more likely to have a successful outcome after surgery. show original
is a critical part of reducing unintended pregnancies show original
was associated with an increased risk of death An increased risk of death was associated with an increased urinary excretion of biomarkers of Tumor Necrosis Factor (TNF) activation at study screening. show original
The patient's kidney biopsy confirmed that they had focal segmental glomerulosclerosis (FSGS) or minimal change disease (MCD). show original
is not a contraindication to treatment with rituximab Patients with Minimal Change Disease who have a history of resistance to corticosteroid therapy do not need to avoid treatment with rituximab. show original
eGFR>45 ml/min/1.73 m2 at screening
Informed consent and assent if applicable

Patient Q&A Section

What are the latest developments in adalimumab for therapeutic use?

"A summary of the efficacy of adalimumab from the FDA as reported in 2011 is given, along with the indications for which the drug is approved." - Anonymous Online Contributor

Unverified Answer

What is hyalinosis, segmental glomerular?

"Hyalinosis is a non-specific finding in segmental glomerular sclerosis. In segmental sclerosis, hyalinosis most likely results from the deposition of fibrin in the glomerular capillaries and arterioles. Hyalinosis has been considered a pathologic sign of renal vasculitis." - Anonymous Online Contributor

Unverified Answer

What causes hyalinosis, segmental glomerular?

"Hyalinosis, segmental glomerular is thought to be reversible. If this is true, then there is a possibility that this is a disorder to be treated and not a disease. If patients presenting with hyalinosis, segmental glomerular have a familial pattern, then a genetic locus may be a possible target for treatment and research." - Anonymous Online Contributor

Unverified Answer

What are common treatments for hyalinosis, segmental glomerular?

"Hyalinosis, segmental glomerulosclerosis is classified into 5 degrees and 10 kinds and these can be treated in a diversity of ways. The cause of hyalinosis, segmental glomerulosclerosis is unknown, but the treatments of the patients can be a reflection of new medical theories and new and improved medicines. A new approach to treat segmental glomerulosclerosis is to observe and analyze the changes on renin mRNA and to use renin inhibitor medicines as a treatment." - Anonymous Online Contributor

Unverified Answer

What are the signs of hyalinosis, segmental glomerular?

"Hyalinosis may be difficult to detect on conventional light microscopy. It can be a clue of early nephrogenic systemic fibrosis and can occur in chronic glomerulonephritis of IgA nephropathy. However, this can be difficult to distinguish from other glomerular diseases, especially IgM nephropathy which has similar pathological features as nephronophthisis." - Anonymous Online Contributor

Unverified Answer

How many people get hyalinosis, segmental glomerular a year in the United States?

"Most cases of hyalinosis, segmental glomerular are due to systemic diseases. If patient has no systemic disease at the time of kidney biopsy, then primary idiopathic hypertensive nephropathy should be considered." - Anonymous Online Contributor

Unverified Answer

Can hyalinosis, segmental glomerular be cured?

"Hyalinosis, SEG, is an important cause of chronic kidney disease. In selected cases where this cause is identified and treated, the glomerulopathy can be cured." - Anonymous Online Contributor

Unverified Answer

Has adalimumab proven to be more effective than a placebo?

"Adalimumab increased the SGRQ-24 scores with a high effect size and improved lung function and SGRQ-24 scores across all three studies, when compared to a placebo and adalimumab plus methotrexate." - Anonymous Online Contributor

Unverified Answer

What is the primary cause of hyalinosis, segmental glomerular?

"Hyalinosis, segmental glomerulus, occurs in the context of a systemic autoimmune process, which triggers an inflammatory attack and complement-mediated focal lesion, and therefore seems to be a secondary phenomenon." - Anonymous Online Contributor

Unverified Answer

Does hyalinosis, segmental glomerular run in families?

"Hyalinosis, segmental glomerular (HSG), familial and familial early onset renal disease are closely similar in age at presentation and severity. Renal biopsy shows hyalinosis and HSG in most affected family members, and may thus be associated with similar familiality." - Anonymous Online Contributor

Unverified Answer

What are the common side effects of adalimumab?

"Common side effects of infliximab and IFN-beta included headaches, fatigue, [malaise, fever, chills, and joint and muscle pain.] The most common of these side effects are the most often attributed to IFN-beta." - Anonymous Online Contributor

Unverified Answer

Who should consider clinical trials for hyalinosis, segmental glomerular?

"At present, this condition is difficult for patients, caregivers and clinicians to recognize, and so patients often choose medical treatment for hyaline nephropathy but are not monitored. Therefore, the development of new treatments and better diagnosis algorithms are important." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
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