Your session is about to expire
← Back to Search
Metformin for Preventing Frailty in Older Adults
Study Summary
This trial will test whether metformin can prevent frailty in older adults.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Side effects data
From 2015 Phase 4 trial • 156 Patients • NCT02002221Trial Design
Find a Location
Who is running the clinical trial?
Media Library
- I have an active cancer that is not skin cancer.I haven't taken steroids, growth hormones, or immunosuppressants in the last month.I haven't taken long-term steroids or immunosuppressants in the last 6 months, except for stable testosterone replacement.I have a severe neurological condition or cognitive impairment.I am considered frail due to having at least three of the following: weak grip, slow walking, low activity, significant weight loss, or exhaustion.I have serious heart or lung problems, like trouble breathing after climbing stairs.I am taking medication that affects my blood sugar levels.I do not have chronic inflammation, autoimmune diseases, or infections like TB, HIV, or hepatitis.I have moderate to severe heart valve disease.I am either a man or a woman.I am 65 years old or older.My blood pressure is not higher than 160/100 mmHg.I have had leg pain from walking due to poor blood flow.My fasting blood sugar is 126 mg/dL or higher, or my 2-hour glucose test result is 200 mg/dL or higher.I have depression that hasn't been treated or my depression score is above 7.I am pre-diabetic based on recent tests, with no diabetes diagnosis in the last year.
- Group 1: Placebo
- Group 2: Metformin
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Are there vacancies currently available for prospective participants in this trial?
"Affirmative, the information on clinicaltrials.gov affirms that this trial is actively searching for participants. Initially posted in April 2016 and last amended in November 2021, 120 patients are sought to join at a single research site."
What has the research revealed about Metformin's efficacy in prior investigations?
"Currently, 170 studies are being conducted on Metformin. Of these active trials, 43 have reached Phase 3 of the clinical trial process. While Pittsburgh is home to the bulk of experiments involving this drug, 1902 different sites across the world are running research into its efficacy."
Who qualifies for enrollment in this clinical trial?
"This trial is searching for 120 elderly individuals with pre-diabetic symptoms. The necessary qualifications must be met, namely: Pre-diabetes based on an oral glucose tolerance test where 2 hours values are between 140 - 199 mg/dL following consumption of a sugar load; no diabetes diagnosis within the last year, Men and women from all ethnicities aged 65 or older who live in a community setting, Hematocrit ≥ 33%, aspartate aminotransferase < 2 X upper limit of normal, alanine aminotransferase < 2 X upper limit of normal, alkaline phosphatase < 2"
What degree of safety has been established for Metformin use?
"Metformin's safety has been partially established through Phase 2 trials and thusly, Power rated it a two out of three on the spectrum of risk."
How many volunteers have enrolled in the experiment thus far?
"Affirmative. Clinicaltrials.gov displays that this experiment is actively seeking individuals, with the original posting occurring on April 1st 2016 and an update to the trial taking place November 3rd 2021. The study requires a total of 120 participants from one medical site."
Is the eligibility criterion for this research study restricted to individuals aged 18 and over?
"This clinical trial has an age range of 65 to 90 years old, which must be met by participants for their inclusion in the study."
For what kind of medical issues is Metformin commonly prescribed?
"Metformin is an efficacious intervention for managing type 1 diabetes mellitus, exercise-induced fatigue and diabetic ketoacidosis."
Share this study with friends
Copy Link
Messenger