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Hormone Therapy

Oxytocin for Postpartum Depression (IN-OXT Trial)

Phase 2
Waitlist Available
Led By Sharon Dekel, PhD
Research Sponsored by Massachusetts General Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
At risk of postpartum depression (PPD)
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 2 months postpartum
Awards & highlights

IN-OXT Trial Summary

This trial is testing whether oxytocin can prevent mental illness in mothers after childbirth.

Eligible Conditions
  • Postpartum Depression
  • Anxiety

IN-OXT Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
You are at risk of experiencing depression after giving birth.

IN-OXT Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~2 months postpartum
This trial's timeline: 3 weeks for screening, Varies for treatment, and 2 months postpartum for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Treatment effect on mother-infant bonding
Secondary outcome measures
Change in anxiety symptoms
Change in depression symptoms
Child development

IN-OXT Trial Design

2Treatment groups
Active Control
Placebo Group
Group I: OxytocinActive Control1 Intervention
Sub-group of participants receiving oxytocin nasal spray (Syntocinon)
Group II: PlaceboPlacebo Group1 Intervention
Sub-group of participants receiving placebo nasal spray

Find a Location

Who is running the clinical trial?

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)NIH
1,953 Previous Clinical Trials
2,660,424 Total Patients Enrolled
6 Trials studying Postpartum Depression
4,286 Patients Enrolled for Postpartum Depression
Massachusetts General HospitalLead Sponsor
2,923 Previous Clinical Trials
13,193,337 Total Patients Enrolled
2 Trials studying Postpartum Depression
22 Patients Enrolled for Postpartum Depression
Sharon Dekel, PhDPrincipal InvestigatorMassachusetts General Hosptial

Frequently Asked Questions

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Recent research and studies
~6 spots leftby Mar 2025