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Study Summary
This trial will test the effects of NYX-458 on mild cognitive impairment, mild dementia, and prodromal or manifest Lewy body dementia.
- Parkinson's Disease
- Mild Cognitive Impairment
- Lewy Body Disease
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
Frequently Asked Questions
Could you tell me if people who are below the age of 25 can participate in this research project?
"According to the screening process for this study, the minimum age an individual can be is 50 and the maximum is 80."
What are the aims of this scientific investigation?
"The main objective of this study, which will be measured over a 14-day period after subjects receive the medication, is to assess rates of adverse events and serious adverse events. Additionally, this study will also look at secondary outcomes like change from baseline on the Two Back test (a measure of working memory), the Groton Maze Learning Test (a measure of problem solving and reasoning), and the Continuous Paired Associate Learning Test (a measure of visual associate memory)."
Is this research program still recruiting new participants?
"No, this particular study is not looking for any more participants. Although, there are 1393 other trials with open recruitment at the moment. This trial was first posted on November 14th, 2019 and updated last on October 26th, 2022."
Are there any dangers to taking NYX-458?
"While there is some evidence of safety from clinical trials, none of the data collected supports efficacy. Consequently, our team has given NYX-458 a score of 2."
Does this medical study have any specific requirements for participants?
"This clinical trial is looking for 99 people with parkinson disease between the ages of 50 and 80. Most notable, patients should meet the following criteria: Has a study partner who can accompany the subject at specified study visits, Informed Consent, Diagnosis of Parkinson's disease and mild cognitive impairment or mild dementia OR diagnosis of mild cognitive impairment or mild dementia with Lewy bodies, Presence of subjective cognitive complaints by the patient, Verifiable impairment, as defined a CGI-S (Clinical Global Impression-Severity) score of at least 3 (mildly ill). Score on the MoCA (Montreal Cognitive Assessment"
How many different hospitals or research centers are participating in this trial?
"Patients are currently being enrolled at this clinical trial's 31 sites which include locations in Decatur, Spokane and West Bloomfield. To limit travel for participants, it is best to select a clinic that is close to your location."
Who else is applying?
What state do they live in?
How old are they?
What site did they apply to?
What portion of applicants met pre-screening criteria?
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