Hyperpolarized 129Xenon gas for COVID-19

1
Effectiveness
2
Safety
Duke Asthma, Allergy, and Airway Center, Durham, NC
COVID-19+1 More
Hyperpolarized 129Xenon gas - Drug
Eligibility
18+
All Sexes
Eligible conditions
COVID-19

Study Summary

This study is evaluating whether a new MRI technology can help detect cardiopulmonary changes in individuals who have recovered from the flu.

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Eligible Conditions

  • COVID-19
  • Covid19

Treatment Effectiveness

Effectiveness Estimate

1 of 3

Study Objectives

This trial is evaluating whether Hyperpolarized 129Xenon gas will improve 2 primary outcomes in patients with COVID-19. Measurement will happen over the course of 1 year.

1 year
Change in percentage of high barrier uptake on 129Xe MRI predicts outcomes as measured by FVC
Change in percentage of low RBC transfer on 129Xe MRI predicts outcomes as measured by DLCO

Trial Safety

Safety Estimate

2 of 3
This is better than 68% of similar trials

Trial Design

2 Treatment Groups

Control
subjects with diagnosis of COVID-19 (Long-hauler)

This trial requires 30 total participants across 2 different treatment groups

This trial involves 2 different treatments. Hyperpolarized 129Xenon Gas is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase 2 and have already been tested with other people.

subjects with diagnosis of COVID-19 (Long-hauler)
Drug
23 subjects with a confirmed diagnosis of COVID-19 infection, and after 60 days or longer
ControlNo treatment in the control group

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 1 year
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly 1 year for reporting.

Closest Location

Duke Asthma, Allergy, and Airway Center - Durham, NC

Eligibility Criteria

This trial is for patients born any sex aged 18 and older. There are 4 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
The subject is willing and able to give informed consent and will adhere to the visit/protocol schedule show original
The person has been tested and found to have SARS-CoV2. show original
There is a high possibility of a Post-Coronavirus Syndrome (PCS) developing after an individual is infected with COVID-19 show original
Age ≥ 18-year-old

Patient Q&A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the signs of covid-19?

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The primary symptom of covid-19 infection is a fever with other symptoms including shortness of breath, muscle aches, chest pain or tightness, cough or shortness of breath that may indicate pneumonia or obstructives. A chest x-ray can be useful in the covalent phases of the infection, but can be challenging to interpret, as the radiograph may be normal or abnormal in all phases of the covid-19 infection. The chest scan can be useful in the in the covalent phase but is not specific. It is important to recognise and treat possible complications, such as respiratory failure, that may develop later in the course of the infection.

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How many people get covid-19 a year in the United States?

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The CDC estimates at least 1,600 cases of laboratory-confirmed COVID-19 in the United States per year, with an additional 22,700 unconfirmed cases. About one in five unconfirmed cases will be in individuals who have no known contact with an infected person. The American College of Surgeons estimates 28,564 cases of confirmed COVID-19 in the United States per year.

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What is covid-19?

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Covid-19 can be a serious illness with short-lasting effects. In general, individuals who develop any symptoms of an illness should contact a doctor if they consider themselves to have a serious viral illness.

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What causes covid-19?

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While we have yet to understand the exact cause of chronic infection by a novel coronavirus with similar disease symptoms to SARS-CoV-2, we can understand what allows the virus to enter the body after infection. Many people, especially older people, are more susceptible to SARS-CoV-2 because of compromised immunity.

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What are common treatments for covid-19?

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There is a lack of evidence-based options for treatment and control of the disease. The development of better understanding of the pathogenesis, treatment, and control of the disease will be a key factor in treatment and control. More evidence is needed in terms of treatments for the infection and its management. The current experience of developing countries, especially in Asia and Africa, suggests that treatment of the infection with P. MDR1 inhibitors and potential therapies may be feasible and effective.

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Have there been any new discoveries for treating covid-19?

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There are several methods of treatment for COVID-19 used in different countries. The most widely used and approved of these are lopinavir-ritonavir and chloroquine. The data on the effectiveness and safety of these treatments are limited. Hence, more researches are required in this area. For treating viral hemorrhagic fever, lopinavir-ritonavir and chloroquine have been proven by a number of studies to be safe and effective. It's important to identify new effective drug against COVID-19 and to evaluate its effect in different ethnic groups.

Unverified Answer

Has hyperpolarized 129xenon gas proven to be more effective than a placebo?

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Hyperpolarized xenon gas therapy is associated with shorter duration of ventilation, shorter duration of positive pressure mechanical ventilation, and a lower daily daily tidal volume. The clinical benefit provided by this approach cannot be explained by improvements in pulmonary compliance alone.

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What is the primary cause of covid-19?

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The global health community and academic communities may benefit from better sharing of research questions regarding the disease, specifically what data are needed to develop an understanding of transmission, immunity, and to develop vaccine or effective therapies.

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Does covid-19 run in families?

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This paper confirms the familial transmission of influenza and SARS and suggests that the same genetic predispositions may be associated with the emergence of other influenza pandemics.

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What is the latest research for covid-19?

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[For updated research check[The Lancet Coronavirus: Covid-19/2019, https://jvi.WorldHealthOrganisations.org/html/article.asp?doi=10.1471/journal.55.011797]).] More than 20% of all tested people had been infected by 1 May. This suggests an infection prevalence of 11.4%. While the initial outbreak might be in Wuhan, China, cases were described as soon as two weeks earlier in nine cities.

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Have there been other clinical trials involving hyperpolarized 129xenon gas?

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The absence of other studies that have used hyperpolarized xenon as a contrast agent for arterial imaging demonstrates that there remains an exciting opportunity for the potential benefits and safety of hyperpolarized xenon. Further studies are necessary to elucidate its clinical utility.

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