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Monoclonal Antibodies

Standard of care plus subcutaneous sarilumab for Coronavirus Disease

Phase 2
Waitlist Available
Led By Westyn Branch-Elliman, MD
Research Sponsored by Westyn Branch-Elliman
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Study subjects will be inpatients with confirmed SARS-CoV-2 testing. Testing is performed at the discretion of the treating physician. Only Veterans will be enrolled.
Positive testing for novel coronavirus SARS-CoV-2019
Timeline
Screening 3 weeks
Treatment Varies
Follow Up within 14 days of enrollment
Awards & highlights

Study Summary

This trial is testing whether sarilumab, an anti-IL6R drug, can help patients with moderate COVID-19 disease. The trial will compare standard care alone to standard care with addition of sarilumab. Up to 120 patients will be enrolled, and the primary outcome is intubation or death within 14 days.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~within 14 days of enrollment
This trial's timeline: 3 weeks for screening, Varies for treatment, and within 14 days of enrollment for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Number of Participants With Intubation or Death

Trial Design

2Treatment groups
Active Control
Group I: Standard of care plus subcutaneous sarilumabActive Control1 Intervention
Standard of care as directed by the treating clinicians, plus sarilumab 400 mg subcutaneous injection. Sarilumab is provided in prefilled syringes/pens containing 200 mg each as is used clinically, and both injections will be given as soon as is convenient after the patient has decided to enroll.
Group II: Standard of careActive Control1 Intervention
Standard of care as directed by the treating clinicians.

Find a Location

Who is running the clinical trial?

Westyn Branch-EllimanLead Sponsor
Westyn Branch-Elliman, MDPrincipal InvestigatorVA Boston Healthcare System
1 Previous Clinical Trials
100,000 Total Patients Enrolled

Frequently Asked Questions

~10 spots leftby Mar 2025