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Taxane

DHA-Paclitaxel for Colorectal Cancer

Phase 2
Waitlist Available
Research Sponsored by Theradex
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Histologically or cytologically confirmed cancer of the colon or rectum
Hepatic: Bilirubin no greater than 1.5 times upper limit of normal (ULN), SGOT or SGPT no greater than 2.5 times ULN
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights

Study Summary

This trial is studying how well DHA-paclitaxel works in treating patients with metastatic colorectal cancer.

Who is the study for?
This trial is for adults with metastatic colorectal cancer who have already tried one chemotherapy regimen without success. They must have measurable disease and no brain metastases or serious health conditions like heart failure, uncontrolled seizures, or severe blood disorders. Pregnant or nursing individuals are excluded, as well as those not using effective contraception.Check my eligibility
What is being tested?
The trial is testing the effectiveness of a chemotherapy drug called DHA-paclitaxel in patients with advanced colorectal cancer that has spread to other parts of the body. It's a Phase II study which means it focuses on how well the drug works and further evaluates its safety.See study design
What are the potential side effects?
DHA-paclitaxel can cause side effects such as low blood cell counts leading to increased infection risk and bleeding problems, nerve damage causing numbness or pain, liver issues, fatigue, allergic reactions during infusion, and possibly hair loss.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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My cancer in the colon or rectum has been confirmed by lab tests.
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My liver function tests are within the required limits.
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I am 18 years old or older.
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My kidney function, measured by creatinine, is within normal limits.
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My cancer has spread to other parts of my body.
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My heart rhythm is normal, and I haven't had a heart attack in the last 3 months.
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I do not have any serious health conditions that are not under control.
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I don't have severe nerve damage, uncontrolled seizures, or spinal cord compression.
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I do not have a serious infection needing IV treatment.
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I do not have cancer that has spread to my brain.
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I have tried one chemotherapy treatment for my advanced cancer without success.
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I am fully active or can carry out light work.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

Find a Location

Who is running the clinical trial?

TheradexLead Sponsor
33 Previous Clinical Trials
1,532 Total Patients Enrolled
Ross C. Donehower, MDStudy ChairSidney Kimmel Comprehensive Cancer Center at Johns Hopkins
5 Previous Clinical Trials
49 Total Patients Enrolled

Media Library

DHA-paclitaxel (Taxane) Clinical Trial Eligibility Overview. Trial Name: NCT00024401 — Phase 2
Colorectal Cancer Research Study Groups:
Colorectal Cancer Clinical Trial 2023: DHA-paclitaxel Highlights & Side Effects. Trial Name: NCT00024401 — Phase 2
DHA-paclitaxel (Taxane) 2023 Treatment Timeline for Medical Study. Trial Name: NCT00024401 — Phase 2

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the deleterious effects of this medication?

"While there is some evidence to support the safety of this medication, it is only in Phase 2 trials. This means that there are no studies supporting its efficacy."

Answered by AI

Are there still opportunities to join this research project?

"According to updated information on clinicaltrials.gov, this study is no longer recruiting patients for participation. Although the trial's last update was in 2008, there are over a thousand other trials currently enrolling individuals."

Answered by AI

How many hospitals are currently participating in this trial?

"Presently, this trial is being conducted in 6 different locations. Some of these include Chicago, Baltimore and Lexington. To limit travel as much as possible, patients are encouraged to select the site that is closest to them."

Answered by AI
~15 spots leftby Mar 2025