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Alpha Blocker

Alpha Blockade for Pheochromocytoma

Phase 3
Waitlist Available
Led By Michael Yeh, MD
Research Sponsored by University of California, Los Angeles
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up from date of surgery (-2 to 3 weeks, -1 day, 30 days, 3 months, 6 months, 1 year)
Awards & highlights

Study Summary

This trial will compare the effects of two different types of drugs used to treat a rare tumor that causes the body to produce too much of the hormone adrenaline.

Eligible Conditions
  • Pheochromocytoma
  • Paraganglioma

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~from date of surgery (-2 to 3 weeks, -1 day, 30 days, 3 months, 6 months, 1 year)
This trial's timeline: 3 weeks for screening, Varies for treatment, and from date of surgery (-2 to 3 weeks, -1 day, 30 days, 3 months, 6 months, 1 year) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Hemodynamic Instability
Secondary outcome measures
Daily Cost of Drug
Morbidity as Assessed by Occurrence of Adverse Events
Mortality
+2 more

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: DoxazosinExperimental Treatment1 Intervention
3-4 weeks prior to date of surgery, patient will start doxazosin 1 mg PO daily. Phenoxybenzamine will then be titrated to a blood pressure <120/80 (sitting) with mild orthostatic hypotension (drop in systolic blood pressure by 20 points or diastolic blood pressure by 10 points from sitting to standing position); systolic blood pressure not less than 90 (standing).
Group II: PhenoxybenzamineActive Control1 Intervention
3-4 weeks prior to date of surgery, patient will start phenoxybenzamine 10mg PO twice daily. Phenoxybenzamine will then be titrated to a blood pressure <120/80 (sitting) with mild orthostatic hypotension (drop in systolic blood pressure by 20 points or diastolic blood pressure by 10 points from sitting to standing position); systolic blood pressure not less than 90 (standing).
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Doxazosin
FDA approved

Find a Location

Who is running the clinical trial?

University of California, Los AngelesLead Sponsor
1,518 Previous Clinical Trials
10,278,721 Total Patients Enrolled
Michael Yeh, MDPrincipal Investigator - University of California, Los Angeles
Resnick Neuropsychiatric Hospital at UCLA, Ronald Reagan UCLA Medical Center, Santa Monica-UCLA Medical Center
St George'S University (Medical School)
Ucla School Of Medicine (Residency)

Media Library

Doxazosin (Alpha Blocker) Clinical Trial Eligibility Overview. Trial Name: NCT03176693 — Phase 3
Pheochromocytoma Research Study Groups: Phenoxybenzamine, Doxazosin
Pheochromocytoma Clinical Trial 2023: Doxazosin Highlights & Side Effects. Trial Name: NCT03176693 — Phase 3
Doxazosin (Alpha Blocker) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03176693 — Phase 3

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Has Doxazosin been accepted by the FDA?

"Doxazosin has been evaluated for efficacy in Phase 3 clinical trials and was found to be safe, so it received a score of 3."

Answered by AI

Is Doxazosin a common medication in clinical trials?

"There are currently 7 ongoing studies researching Doxazosin with 2 trials in Phase 3. However, there are 36 different locations running clinical trials for Doxazosin--not just Oklahoma City, Oklahoma."

Answered by AI

How many test subjects are currently enrolled in this research?

"That is correct, the listing on clinicaltrials.gov indicates that this study is still open to enrolling patients. The trial was created on May 5th, 2017 and has had 60 patients enrolled from 1 location."

Answered by AI

Are there any available positions for patients who would like to participate in this trial?

"The clinical trial is currently looking for participants and was originally posted on May 5th, 2017. The study received its last update on September 18th, 2019."

Answered by AI

Doxazosin is often times prescribed for what reason?

"Doxazosin is a medication that urologists often prescribe to patients with an enlarged prostate (bph). It can also be used to relieve urinary retention and dysuria, as well as treating pheochromocytomas."

Answered by AI
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~5 spots leftby Mar 2025