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BMS-986207 for Non-Small Cell Lung Cancer

Phase 2
Waitlist Available
Research Sponsored by Bristol-Myers Squibb
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
No prior systemic anti-cancer treatment given as primary therapy for advanced or metastatic NSCLC
Measurable disease as per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1
Timeline
Screening 3 weeks
Treatment Varies
Follow Up from randomization to time of death, 2.3 months
Awards & highlights

Study Summary

This trial will test a new cancer treatment involving a combination of drugs. The goal is to see if it is safe and effective for people with stage IV non-small cell lung cancer.

Eligible Conditions
  • Non-Small Cell Lung Cancer

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~from randomization to time of death, 2.3 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and from randomization to time of death, 2.3 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Progression Free Survival by BICR
Secondary outcome measures
Duration of Response (DOR) by Investigator
Number of Participants Who Had AEs, SAEs, AEs Leading to Discontinuation and Deaths.
Overall Response Rate (ORR) by BICR
+3 more

Side effects data

From 2022 Phase 2 trial • 1 Patients • NCT05005273
100%
Cardiac arrest
100%
Sepsis
100%
Nausea
100%
Blood lactate dehydrogenase increased
100%
Hypoalbuminaemia
100%
Eczema
100%
Blood alkaline phosphatase increased
100%
Hyponatraemia
100%
Bronchitis
100%
Hypokalaemia
100%
80%
60%
40%
20%
0%
Study treatment Arm
Nivolumab 360 mg + Ipilimumab 1 mg/kg + BMS-986207 600 mg
Nivolumab 360 mg + Ipilimumab 1 mg/kg + Placebo

Trial Design

2Treatment groups
Experimental Treatment
Group I: Arm BExperimental Treatment3 Interventions
Group II: Arm AExperimental Treatment3 Interventions
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Nivolumab
2014
Completed Phase 3
~4750
Ipilimumab
2014
Completed Phase 3
~2640
BMS-986207
2022
Completed Phase 2
~10

Find a Location

Who is running the clinical trial?

Bristol-Myers SquibbLead Sponsor
2,629 Previous Clinical Trials
4,126,300 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the BMS-986207 research landscape?

"BMS-986207 was first studied a decade ago, in 2009, at Texas Children's Hospital. To date, there have been 18638 completed trials worldwide. Currently, 796 clinical trials are still running; many of which are based in Orange City, Kentucky."

Answered by AI

Which patients does BMS-986207 help the most?

"BMS-986207 has shown to be effective in the treatment of malignant neoplasms, unresectable melanoma, and previous anti-angiogenic therapy."

Answered by AI

Are volunteers still being accepted for this experiment?

"Yes, this is an ongoing study that is currently seeking patients. The trial was first posted on October 3rd, 2020 and has since been updated November 15th, 2020. A total of 180 individuals are needed to be recruited from 19 different locations."

Answered by AI

How many people are part of this clinical trial?

"That is correct, the information available on clinicaltrials.gov suggests that this trial is seeking new participants. The first posting was on October 3rd, 2020 and there have been edits made as recently as November 15th, 2020. In total, the study needs to enrol 180 patients from 19 different sites."

Answered by AI

Are there any risks associated with taking BMS-986207?

"BMS-986207 is still being tested for efficacy in Phase 2 trials, but there is some data supporting its safety which landed it a score of 2."

Answered by AI

In how many different places is this clinical trial being performed?

"This clinical trial has 20 locations, with the primary operating centres being Saint Alphonsus Regional Medical Center in Orange City, Kentucky, Mid Florida Hematology and Oncology Center in Edgewood, Idaho, and Compassionate Cancer Care Medical Group in Boise, New york."

Answered by AI
~0 spots leftby Mar 2025