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Radiation Therapy for Breast Cancer (DCIS Trial)
DCIS Trial Summary
This trial is testing whether adding a tumour bed boost after breast conserving surgery (BCS) in women with non-low risk ductal carcinoma in situ (DCIS) reduces the risk of local recurrence. There are two fractionation arms in this trial: a shorter fractionation arm and a standard fractionation arm. The overall objectives of the trial are to improve the outcome of women with non-low risk DCIS treated with BCS and to individualize treatment selection for women with DCIS to achieve long term disease control with minimal toxicity.
DCIS Trial Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowDCIS Trial Timeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.DCIS Trial Design
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Who is running the clinical trial?
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- I have significant difficulty in performing daily activities.I am not pregnant or breastfeeding.I am a woman aged 18 or older.My breast cancer is non-invasive and confirmed by tissue analysis.I am at high risk of breast cancer returning due to my age and specific tumor characteristics.My breast cancer involves multiple areas or widespread calcium deposits and couldn't be fully removed with a lumpectomy ensuring clear edges.My cancer has not spread to my lymph nodes.I have cancer in both breasts at the same time.I have no current or past cancers, except for certain treated cancers over 5 years ago.My breast cancer has come back in the same area.My radiation therapy will start no later than 12 weeks after my last surgery.My cancer has spread to my lymph nodes.I have DCIS in both breasts.I have had mammograms of both breasts in the last 6 months.My breast cancer surgery removed all cancer with clear edges of at least 1mm.I can take care of myself and perform daily activities.I have had cancer in my other breast before.You are expected to live for more than 5 years.I have a serious illness like heart, lung, or kidney disease that prevents surgery or radiation.My surgeon and radiation oncologist agree I can have breast-saving surgery and radiation.
- Group 1: Arm 1 (Standard WB Fractionation)
- Group 2: Arm 4 (Shorter WB fractionation + Boost)
- Group 3: Arm 3 (Standard WB fractionation+Boost)
- Group 4: Arm 2 (Shorter WB Fractionation)
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Is Shorter WB fractionation a danger to patients?
"There is some clinical evidence supporting the efficacy of Shorter WB fractionation, as well as data from multiple rounds of testing which supports its safety. This gives it a score of 3 on our scale."
Are there many locations in the United States conducting this research study?
"Currently, this research is being conducted in 20 different locations. They are located in Kelowna, Victoria and Hearst as well as 20 other cities. If you choose to participate, it would be beneficial to select a site near you to limit travel expenses."
Are investigators still enrolling individuals for this research?
"Unfortunately, this particular study is no longer looking for patients. Although it was last updated on December 3rd, 2019, the trial originally posted on June 1st, 2007. There are 2615 other trials that are still open and recruiting right now."
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